A5026430359- Electron Spin Resonance Studies
- Advanced NMR Techniques and Applications
- Magnetism in coordination complexes
- X-ray Diffraction in Crystallography
- Lanthanide and Transition Metal Complexes
- Crystallization and Solubility Studies
- Muon and positron interactions and applications
- Photochemistry and Electron Transfer Studies
- Nuclear Physics and Applications
- Clinical Nutrition and Gastroenterology
- Nanopore and Nanochannel Transport Studies
- Atmospheric and Environmental Gas Dynamics
- Healthcare Systems and Challenges
- Advanced MRI Techniques and Applications
- Molten salt chemistry and electrochemical processes
- NMR spectroscopy and applications
- Mass Spectrometry Techniques and Applications
- Spectroscopy and Quantum Chemical Studies
- Protein Structure and Dynamics
- Noncommutative and Quantum Gravity Theories
- Atomic and Subatomic Physics Research
- Radioactive element chemistry and processing
ETH Zurich
2022-2025
Abstract. Trityl radicals feature prominently as polarizing agents in solid-state dynamic nuclear polarization experiments and spin labels distance distribution measurements by pulsed dipolar EPR spectroscopy techniques. Electron-spin coherence lifetime is a main determinant of performance these applications. We show that protons contribute substantially to decoherence, although the were designed with aim reducing proton hyperfine interaction. By dynamics simulations, we can trace back...
Abstract. The intermolecular hyperfine relaxation-induced dipolar modulation enhancement experiment (ih-RIDME) is a pulse electron paramagnetic resonance (EPR) that can be used to probe the properties of nuclear spin bath in vicinity an unpaired electron. underlying mechanism spectral diffusion during mixing block. A quantitative description kinetics being applied establish ih-RIDME data model allows one extend this method systems with heterogeneous arrangements assuming distribution local...
A new method to quantitatively analyze heterogeneous distributions of local proton densities around paramagnetic centers in unstructured and weakly structured biomacromolecules soft matter is introduced, its feasibility demonstrated on aqueous solutions stochastically spin-labeled polysaccharides. This based the pulse EPR experiment ih-RIDME (intermolecular hyperfine relaxation-induced dipolar modulation enhancement). Global analysis a series RIDME traces allows for mathematically stable...
Nuclear magnetic resonance suffers from an intrinsically low sensitivity, which can be overcome by dynamic nuclear polarization (DNP). Gd(III) complexes are attractive exogenous polarizing agents for magic angle spinning (MAS) DNP due to their high chemical stability in contrast nitroxide-based radicals. However, even the state-of-the-art have so far provided relatively signal enhancements of ca. 36 comparison standard biradicals, show over 200. Here, we report a series new and that observed...
The intermolecular hyperfine relaxation-induced dipolar modulation enhancement (ih-RIDME) experiment has a promising potential to quantitatively characterize the nuclear environment in 0.8-3 nm range around an electron spin. Such information about spatial arrangement of nuclei is great interest for structural biology as well dynamic polarization (DNP) methods. In order develop reliable and sensitive spectroscopic tool, solid data model needs be established. Here, we attempt provide...
Relaxation-induced dipolar modulation enhancement (RIDME) time trace shapes reveal linear scaling with the proton concentration in homogeneous glassy samples. We describe here an approximate diffusion equation-based analysis of such data, which uses only two fit parameters and allows for global data fitting good accuracy. By construction, approach should be transferable to other pulse EPR experiments longitudinal mixing block(s) present. The appear sensitive type matrix can thus used sample...
Abstract. Trityl radicals feature prominently as polarizing agents in solid-state dynamic nuclear polarization experiments and spin labels distance distribution measurements by pulsed dipolar EPR spectroscopy techniques. Electron-spin coherence lifetime is a main determinant of performance these applications. We show that protons contribute substantially to decoherence, although the were designed with aim reducing proton hyperfine interaction. By dynamics simulations, we can trace back...
Abstract. Intermolecular hyperfine relaxation-induced dipolar modulation enhancement experiment (ih-RIDME) is a pulse EPR that can be used to probe the properties of nuclear spin bath in vicinity an unpaired electron. The underlying mechanism spectral diffusion electron during mixing block. A quantitative description kinetics being applied establish ih-RIDME data model allows extend this method for systems with heterogeneous arrangements assuming distribution local densities. heterogeneity...
The remarkably narrow central line in the electron paramagnetic resonance spectrum and very weak zero-field splitting (ZFS) make [GdIII(NO3Pic)] ([GdIII(TPATCN)]) an attractive starting point for development of spin labels. For retaining this parent complex when modifying it with a substituent enabling bioconjugation, alkyl somehow remote functional group as at picolinate moiety was found to be highly suitable because ZFS stayed weak, even if threefold axial symmetry broken. is so that...
The intermolecular hyperfine relaxation-induced dipolar modulation enhancement (ih-RIDME) experiment has a promising potential to quantitatively characterize the nuclear environment in 0.8-3 nm range around an electron spin. Such information about spatial arrangement of nuclei is great interest for structural biology as well dynamic polarization (DNP) methods. In order develop reliable and sensitive spectroscopic tool, solid data model needs be established. Here, we attempt provide...
A new method to quantitatively analyse inhomogeneous distributions of local proton densities around paramagnetic centers in unstructured bio-polymers, disordered biomolecules and soft matter is introduced, its feasibility demonstrated on aqueous solutions stochastically spin-labeled polysaccharides. The technique based a dipolar EPR pulse sequence ih-RIDME (intermolecular hyperfine relaxation-induced modulation enhancement). global analysis series RIDME traces offers mathematically stable...