A5102008778- Bipolar Disorder and Treatment
- Circadian rhythm and melatonin
- Genetic Associations and Epidemiology
- Schizophrenia research and treatment
- Obsessive-Compulsive Spectrum Disorders
- Pharmacological Effects and Toxicity Studies
- Privacy-Preserving Technologies in Data
- Genetics and Neurodevelopmental Disorders
- Antibiotic Resistance in Bacteria
- Anomaly Detection Techniques and Applications
- Fuel Cells and Related Materials
- Advancements in Solid Oxide Fuel Cells
- Child and Adolescent Psychosocial and Emotional Development
- Genomics and Rare Diseases
- Time Series Analysis and Forecasting
- Gold and Silver Nanoparticles Synthesis and Applications
- Adversarial Robustness in Machine Learning
- Building Energy and Comfort Optimization
- Suicide and Self-Harm Studies
- Air Quality Monitoring and Forecasting
- Genomic variations and chromosomal abnormalities
- Cancer Treatment and Pharmacology
- Autism Spectrum Disorder Research
- Energy Load and Power Forecasting
- Technology and Data Analysis
Seoul National University
2023-2024
Samsung (South Korea)
2017-2022
Samsung Medical Center
2017-2018
Sungkyunkwan University
2018
Samsung (United States)
2018
Biomedical Research Institute
2018
The efficacy and utility of long-term prophylactic treatment in patients with bipolar disorders (BDs) have not been fully explored. This study aims to estimate the clinical response BDs mood stabilizer identify factors associated that response. subjects consisted 80 I or II disorder who had receiving lithium and/or valproate for more than 2 years at a single clinic. best option based on algorithms was evaluated using Alda scale. Clinical characteristics were lifetime basis. Patients...
Of 11 mcr-1-harboring plasmids previously identified from livestock in Korea, we performed whole plasmid sequencing on 3 and determined the genetic structure surrounding mcr-1 for all plasmids. Transconjugation frequencies were measured competitive growth experiments to investigate fitness cost of each plasmid. Although they belong different clones, plasmids, pEC006 pEC019, highly similar first mcr-1-carrying Incl2-type plasmid, pHNSHP45. Another IncX4-type pEC111, had completely these but...
Abstract Purpose Given that switching to clozapine is an important treatment option for tardive movement syndrome (TMS), its effect and clinical correlates have not been fully explored yet. This study investigated the improvement of TMS after factors associated with response in a naturalistic outpatient setting. Methods Subjects were 35 patients schizophrenia or bipolar disorder receiving only as antipsychotic drug more than 12 months. Their prior antipsychotics switched onset dyskinesia...
When evaluating the long-term treatment response to mood stabilizers using Alda scale, stabilizer combination therapy is typically considered a confounding factor, and patients receiving are excluded from analysis. However, this may result in bias if those under worse responders. This study aims explore whether scale applicable taking lithium valproate therapy. We compared monotherapy of two drugs, investigated clinical correlates responses each drug.The subjects consisted 102 with bipolar I...
Bipolar disorder (BD) has the greatest suicide risk among mental and physical disorders. A recent genome-wide association study (GWAS) of European ancestry (EUR) samples revealed that genetic etiology attempt (SA) was not only polygenic but also, in part, diagnosis-specific. The authors aimed to examine whether score (PRS) for SA derived from is associated with or repeated attempts Korean patients BD. This also investigated shared heritability disorders which showed an increased a high correlation
Abstract Background Given its diverse disease courses and symptom presentations, multiple phenotype dimensions with different biological underpinnings are expected bipolar disorders (BPs). In this study, we aimed to identify lifetime BP psychopathology dimensions. We also explored the differing associations I (BP-I) II (BP-II) disorders. Methods included a total of 307 subjects BPs in analysis. For factor analysis, chose six variables related clinical courses, 29 indicators covering symptoms...
Objectives In this study, we aimed to determine the role of genetic variations within zinc finger protein 804A ( ZNF ) gene, a candidate for psychosis risk‐conferring in development schizophrenia SZ and bipolar disorder BP Korean population. Methods A total 921 patients with , I ‐I) II ‐ disorder, 502 control subjects participated study. Twenty‐one tag single nucleotide polymorphisms SNP s) across genomic region seven reference s based on previous reports were genotyped. We applied logistic...
ST8SIA2 and NCAM1 are functionally related genes forming polysialic acid (PSA) - neural cell adhesion molecule (NCAM) complex in suprachiasmatic nucleus (SCN), the regulating site of circadian biological rhythm. In this study, relationship with seasonal rhythms human behavior was explored. Subjects were 261 healthy Korean adults who free any history clinically significant psychiatric symptoms. The phenotypes preference change mood (seasonality) measured by Composite Scale Morningness...
Objective Bipolar disorder (BD) is complex genetic disorder. Therefore, approaches using clinical phenotypes such as biological rhythm disruption could be an alternative. In this study, we explored the relationship between melatonin pathway genes with circadian and seasonal rhythms of BD.Methods We recruited clinically stable patients BD (n=324). measured variation mood behavior (seasonality), preference, on a lifetime basis. analyzed 34 variants in four (<i>MTNR1a</i>,...
현재 기업이나 연구소의 기술유출을 예방⋅방지하기 위해 주기적으로 기술보호수준을 측정하 는 실태조사를 통해 인적보안요인을 측정하고는 있지만, 핵심인력에 대한 평가항목은 없다. 기 술유출이 주로 의해 발생함에도 불구하고 관리방안은 부재한 실정 이다. 산업기술유출 방지를 기업 특성에 맞는 핵심인력 위험성 평가지표를 개발하여 인적 보안을 강화하여 산업기술유출범죄를 예방할 필요가 있다. 따라서 이 연구는 핵심인력의 기술유 출사건 분석을 대상 기술유출 평가지표 개발을 제안하고자 한다. 연구 핵심인력을 집중․관리하기 위한 개발한다는 점에서 기존의 폭력범죄 위험 성 평가와 차이가 위험군을 변별할 수 있는 기준점을 위 험성 평가지발 개발은 기술유출사건 개발하였다. 2013년부터 2023년까 지 발생한 166건 기술유출은 ① 공모에 발생하는 경 우가 많고, 공범의 경우 전⋅현직 직장동료인 경우가 많으며, ② 대기업에서 해외로의 유출 이동 발생하고 있으며, 해외기업에서는 경제적 이익만을 제공하는...
문장제 문제는 단순한 수학적 수식으로 구성된 연산문제와는 달리 언어적으로 표현된 문제 안에서 내용을 찾아 그것을 표현하는 과정을 필요로 한다. 이는 고차원적인 인지적 전략을 요구하며 학습자는 사고력과 추론능력, 이해력, 언어와 읽기 등을 고루 활용해야 하지만 대부분의 학습장애학생들은 문제를 해결하는데 어려움을 겪고 있다. 본 연구에서는 학습장애학생이 과부하를 적게 받으면서 학습할 수 있으며 또한 학생들에게 전문가의 예시를 단계적으로 제시하는 WOE (Work-Out Examples: WOE) 기반 스마트러닝 학습시스템을 제시한다. 시스템의 특징은 다음과 같다. 첫째, WOE를 순차적으로 따라하면서 부하 없이 자연스럽게 문제해결전략을 습득할 둘째, 학습자의 학습 동기를 높이고 흥미를 유발시킨다. 셋째, 시공간을 초월한 학습이 가능하기 때문에 학습자 스스로 학습을 조절하는 자기주도적 학습능력이 향상될 적용결과는 학습장애학생의 수준에 맞는 단계가 제공되고 지속적인 피드백이 있기...
This work presents the first demonstration of a convolutional neural network (CNN) based touch screen panel(TSP) sensitivity prediction. By developing combined model and numerical simulation, we have accomplished four distinct achievements: (1) development novel TSP pattern generation algorithm (2) establishment an automation simulation system for massive database; (3) CNN with stable strong performance; (4) >100x improvement tact time in performance As such, this opens up new class...