Diabetes mellitus is a multi-faceted metabolic disorder where there increased oxidative stress that contributes to the pathogenesis of this debilitating disease. This has prompted several investigations into use antioxidants as complementary therapeutic approach. Alpha lipoic acid, naturally occurring dithiol compound which plays an essential role in mitochondrial bioenergetic reactions, gained considerable attention antioxidant for managing diabetic complications. Lipoic acid quenches...

Diabetic cystopathy is a well-recognized complication of diabetes mellitus that usually develops in middle-aged or elderly patients with long-standing and poorly controlled hyperglycemic disease can have broad-spectrum clinical presentation. Patients may be asymptomatic, wide variety voiding complaints from overactive bladder urge incontinence to decreased sensation overflow incontinence. This review focuses on the pathophysiological mechanisms responsible for urologic complications...

the potential role of statins in treating chronic obstructive pulmonary disease (COPD) is controversial, and it unclear what anatomic COPD lesions affect.to determine whether an intervention simvastatin could alter cigarette smoke-induced hypertension.we exposed guinea pigs to smoke for 6 months. In half animals, therapy was initiated after 3 months exposure. Pulmonary arterial systolic pressures were monitored weekly with a radiotelemetric catheter; additional physiologic morphologic...

Physical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases. A partial list of proposed mechanisms exercise-induced cardioprotection include induction heat shock proteins, increase in cardiac antioxidant capacity, expression endoplasmic reticulum stress anatomical and physiological changes the coronary arteries, nitric oxide production, adaptational mitochondria, increased autophagy, improved function sarcolemmal and/or mitochondrial...

There are alarming increases in the incidence of obesity, insulin resistance, type II diabetes, and cardiovascular disease. The risk these diseases is significantly reduced by appropriate lifestyle modifications such as increased physical activity. However, exact mechanisms which exercise influences development progression disease unclear. In this paper we review some important exercise-induced changes cardiac, vascular, blood tissues discuss recent clinical trials related to benefits...

Objective . Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is often present in diabetic (DB) patients. Both conditions are associated with endothelial dysfunction and cardiovascular disease. We hypothesized that further compromised CIH. Methods Adult male (BKS.Cg‐ Dock7 m +/+ Lepr db /J) ( db/db ) mice (10 weeks old) their heterozygote littermates were subjected to CIH or air (IA) for 8 weeks. Mice separated into 4 groups: IA (intermittent nondiabetic),...

Objective . Obstructive sleep apnea (OSA) is characterized by recurrent airway collapse that causes chronic intermittent hypoxia (CIH). OSA associated with systemic inflammation and oxidative stress resulting in endothelial dysfunction cardiovascular disease (CVD). Alpha lipoic acid (ALA) a potent antioxidant anti-inflammatory properties. We hypothesized dietary ALA can improve function of mice exposed to CIH. Methods Mice were either CIH or air (IA) treated (0.2% <mml:math...

Gestational diabetes mellitus (GDM) is defined as glucose intolerance first diagnosed during pregnancy. This condition shares same array of underlying abnormalities occurs in outside pregnancy, for example, genetic and environmental causes. However, the role a sedentary lifestyle and/or excess energy intake more prominent GDM. Physically active women are less likely to develop GDM other pregnancy-related diseases. Weight gain pregnancy causes increased release adipokines from adipose tissue;...

An intravenous injection of oleic acid into animals can produce a lung injury with hypoxaemia and pulmonary vascular hyper-permeability. Although is used as model acute respiratory distress syndrome (ARDS), the precise mechanisms are still unclear. We have investigated whether thromboxane A(2) (TXA(2)) participated in evaluated efficacy ozagrel, TXA(2) synthase inhibitor, on guinea-pigs. Oleic increased plasma level TXB(2), stable metabolite TXA(2), time-course TXB(2) was similar to that...

The effect of antioxidants on ageing type 2 diabetic (T2D) hearts during exercise is unclear. We hypothesized that GSH therapy reduces mitochondrial oxidative stress (mOXS) and cell death in db/db mice hearts.The cardiac mOXS was evaluated both vivo vitro.During exercise, treatment protected from exaggerated without reducing total death. Despite similar death, investigations apoptosis-specific single-stranded DNA breaks necrosis-specific damage provided the first evidence a shift necrosis to...