A5042686905- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Breast Cancer Treatment Studies
- Pancreatic and Hepatic Oncology Research
- Breast Lesions and Carcinomas
- Esophageal and GI Pathology
- Cancer and Skin Lesions
- Pediatric Hepatobiliary Diseases and Treatments
- CAR-T cell therapy research
- Fetal and Pediatric Neurological Disorders
- Cellular Mechanics and Interactions
- Gastrointestinal Tumor Research and Treatment
- Nutrition, Genetics, and Disease
- Male Breast Health Studies
- Nonmelanoma Skin Cancer Studies
- Breast Implant and Reconstruction
- Genetics, Bioinformatics, and Biomedical Research
- Salivary Gland Tumors Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Economic and Financial Impacts of Cancer
- BRCA gene mutations in cancer
- Neuroendocrine Tumor Research Advances
- Single-cell and spatial transcriptomics
- Gastric Cancer Management and Outcomes
- Neonatal and fetal brain pathology
Rockefeller University
2024
AdventHealth Orlando
2022
Florida Hospital Cancer Institute
2021-2022
ProMedica Russell J. Ebeid Children's Hospital
2019
Medica (United States)
2014-2018
Promentis Pharmaceuticals (United States)
2018
ProMedica Toledo Hospital
2012
Mount Sinai Medical Center
1999
National guidelines recommend sentinel lymph node biopsy (SLNB) be offered to patients with > 10% likelihood of (SLN) positivity. On the other hand, do not SLNB for T1a tumors without high-risk features who have < 5% a positive SLN. However, decision perform is less certain higher-risk T1 melanomas in which expected 5%-10% time. We hypothesized that integrating clinicopathologic 31-gene expression profile (31-GEP) score using advanced artificial intelligence techniques would provide more...
Stereotaxic needle core biopsy of breast lesions using a regular mammographic table with an adaptable stereotaxic device.J S Caines, M D McPhee, G P Konok and B A WrightAudio Available | Share
Objective: A 31-gene expression profile (GEP) test that has been clinically validated identifies melanoma patients with low (Class 1) or high 2) risk of metastasis based on primary tumor biology. This study aimed to prospectively evaluate the impact clinical management patients.Methods: Physicians at 16 dermatology, surgical medical oncology centers examined assess features melanoma. Recommendations for follow-up and surveillance were collected. Following consent patient performance GEP...
National Comprehensive Cancer Network (NCCN) guidelines for cutaneous melanoma (CM) recommend physicians consider increased surveillance patients who typically have lower survival rates (stages IIB-IV as determined by the American Joint Committee on (AJCC), 8th edition). However, up to 15% of identified having a low recurrence risk I-IIA) experience disease recurrence, and some high will not any recurrence. The 31-gene expression profile test (31-GEP) stratifies patient into (Class 1) 2) has...
In order to determine if intraoperative ultrasound (US)-guided excision is a feasible procedure, we prospectively studied 15 female patients between July 1996 and December 1998 for US-detected nonpalpable breast lesions. Intraoperative US was used by the operating surgeon identify lesion, guide its excision, evaluate specimen document complete removal. A control group of with mammographically detected lesions comparison. These underwent preoperative needle localization, lesions, radiographs....
Abstract Purpose The common marmoset ( Callithrix jacchus ) provides an ideal model to study early development of primates, and in viv o platform validate conclusions from vitro studies human embryos embryo models. Currently, however, no established staging atlas embryonic exists. Using high-resolution, longitudinal ultrasound scans on live pregnant marmosets, we present the first dynamic vivo imaging entire primate gestation beginning with attachment until last day before birth. Methods Our...
A 52-year-old Caucasian female was referred to our facility for recurrent episodes of post-prandial right upper quadrant abdominal pain. This associated with a 12 pound weight loss over period one year. Her past medical history significant duodenum adenocarcinoma treated Whipple procedure two years prior. pancreatic stent placed at the pancreatico-enteric anastomosis during surgery. She is former smoker, denies use alcohol or any other recreational drugs. medications include omeprazole and...
Recent high-throughput-sequencing of cancer genomes has identified oncogenic mutations in the B-Raf genetic locus as one critical events melanomagenesis. encodes a serine/threonine kinase that regulates MAPK/ERK (MEK) and extracellular signal-regulated (ERK) protein cascade. In normal cells, activity is tightly regulated required for cell growth survival. gain-of-function melanoma frequently lead to unrestrained growth, enhanced invasion increased viability cells. Although it clear invasive...
Background: Malignant melanoma is one of the most common cancers occurring in pregnancy, although diagnosis and treatment remain controversial. The case a 27-year-old woman, who was successfully diagnosed treated, presented here. Case: Case notes histopathology were reviewed. patient underwent wide local excision lesion. Lymphoscintigraphy sentinel lymph node biopsy also used for staging. Results: subsequently delivered healthy, full-term fetus via cesarean section. At time publication, both...
Purpose: Ball-valve syndrome (BVS) is a rare condition in which gastric tumor herniates into duodenum and might cause intermittent and/or partial outlet obstruction. A variant of this retrograde BVS, even rarer entity duodenal polypoid mass prolapses stomach give rise to Various diverse pathological conditions can both anterograde BVS. Mechanical complications bulb polyps are rare, most frequently reported with inflammatory fibroid polyps. We presenting 4 cases BVS (2 2 retrograde)....
Purpose: Pancreatic cancer is among the leading cancers in United States and constitutes about 3% of all cancers. The prognosis pancreatic baneful with a 5 year survival rate 6% for stages combined. much better local neoplasms (23%) compared regional distant Early detection tumor key to achieving survival. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has become an important tool early diagnosis staging these neoplasms. We report retrospective analysis lesions diagnosed by...
Objective: To calculate and compare adherence to pancreatic cancer care quality indicators related outcomes at three hospitals within our health system determine their relatedness. Design: Retrospective review of registry data patient charts from January 1, 2000 – December 31, 2010. Setting: Three performing resections a single system. Patients: All patients undergoing resection for the treatment cancer. Main Outcome Measures: Adherence published indicators, survival, surgical institutional...
Abstract Background and Objective: BRCA testing for patients (pts) with triple negative breast cancer (TNBC) is important because it has secondary prevention implications multigenerational allowing earlier detection of gene carriers in the family enabling primary prevention. And advent PARP inhibitors also treatment implications. The NCCN guidelines recommended January 2015 that be performed all pts TNBC diagnosed at age 60 or younger regardless race, ethnicity history. To understand...