A5074118637- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- biodegradable polymer synthesis and properties
- Advanced Polymer Synthesis and Characterization
- Analytical Chemistry and Chromatography
- Surfactants and Colloidal Systems
- Hydrogels: synthesis, properties, applications
- Crystallization and Solubility Studies
- Protein purification and stability
- Microencapsulation and Drying Processes
- Inhalation and Respiratory Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Polymer Science and PVC
- Nanoparticle-Based Drug Delivery
- Dermatology and Skin Diseases
- Biopolymer Synthesis and Applications
- Pancreatic function and diabetes
- Polysaccharides Composition and Applications
- Synthesis and properties of polymers
- Gastrointestinal motility and disorders
- RNA Interference and Gene Delivery
- Contact Dermatitis and Allergies
Freie Universität Berlin
2015-2024
Sittingbourne Memorial Hospital
2005
Pfizer (Germany)
2005
The University of Texas at Austin
1990-2002
Universidade de Santiago de Compostela
1995
Austin College
1989-1995
Abstract Polymer microspheres and fibers are formed with a versatile new process, precipitation compressed fluid antisolvent. By spraying 1 wt. % polystyrene in toluene solution into CO 2 through 100‐μm nozzle, diameters from 0.1 to 20 μm as the density decreases 0.86 0.13 g/cm 3 . The uniform submicron spheres produced at high due part rapid atomization by large intertial low interfacial forces. Fibers, without microporosity, obtained higher polymer concentrations where viscous forces...
Delivery systems with a pulsatile-release pattern are receiving increasing interest for the development of drugs which conventional controlled drug-release continuous release not ideal. These often have high first-pass effect or special chronopharmacological needs. A profile is characterized by time period no (lag time) followed rapid and complete drug release. Pulsatile drug-delivery can be classified into site-specific in released at desired site within intestinal tract (e.g., colon),...
Pseudoephedrine HCl, a highly water-soluble drug, was entrapped within poly (methyl methacrylate) microspheres by water/oil/water emulsification-solvent evaporation method. An aqueous drug solution emulsified into of the polymer in methylene chloride, followed emulsification this primary emulsion an external phase to form emulsion. The middle organic separated internal drug-containing from continuous phase. Microspheres were formed after solvent and precipitation. content increased with...
Sulfadiazine beads were prepared by dropping drug-containing solutions of the positively charged polysaccharide, chitosan, into tripolyphosphate (TPP) solutions. The droplets instantaneously formed gelled spheres ionotropic gelation, entrapping drug within a three-dimensional network ionically linked polymer. To achieve maximum content, high payloads, short gelation times, low TPP concentrations, and internal to external phase ratio required. chitosan showed pH-dependent swelling dissolution...
Drug containing biodegradable poly(+/-)lactide microparticles were prepared by using a spray-drying technique. Formulations model drugs in either dissolved (progesterone) or dispersed state (theophylline) spray-dried. The method was less dependent on the solubility characteristics of drug when compared with traditional microencapsulation techniques such as phase separation solvent evaporation techniques. Differential scanning calorimetry and electron microscopy used to characterize...
The adsorption of biomolecules to the surface nanoparticles (NPs) following administration into biological environments is widely recognized. In particular, "protein corona" well understood in terms formation kinetics and impact upon interactions NPs. Its presence an essential consideration design therapeutic present study, protein coronas six polymeric prospective use were investigated. These included three colloidal NPs-soft core-multishell (CMS) NPs, plus solid cationic Eudragit RS...