A5066492549- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Insect Pheromone Research and Control
- Insect and Arachnid Ecology and Behavior
- Advanced Chemical Sensor Technologies
- Neural dynamics and brain function
- Plant and animal studies
- Biochemical Analysis and Sensing Techniques
- Cephalopods and Marine Biology
- Animal Behavior and Reproduction
- Insect Utilization and Effects
- Physiological and biochemical adaptations
- Species Distribution and Climate Change
- Plant and Biological Electrophysiology Studies
- Circadian rhythm and melatonin
- Hereditary Neurological Disorders
- Cellular transport and secretion
- Insect behavior and control techniques
- Photoreceptor and optogenetics research
- Nerve injury and regeneration
- Marine Biology and Environmental Chemistry
- Connexins and lens biology
- Animal Vocal Communication and Behavior
- Bat Biology and Ecology Studies
- Evolutionary Game Theory and Cooperation
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2015-2024
National Institutes of Health
2014-2024
Health and Human Development (2HD) Research Network
2008-2017
University of Hyderabad
2012
University of Washington
2012
California Institute of Technology
1996-2005
University of California, San Diego
2001
Scripps Institution of Oceanography
2001
Yale University
1987-1996
Stimulus-evoked oscillatory synchronization of neurons has been observed in a wide range species. Here, we combined genetic strategies with paired intracellular and local field potential (LFP) recordings from the intact brain Drosophila to study mechanisms odor-evoked neural oscillations. We found common food odors at natural concentrations elicited oscillations LFP made mushroom body (MB), site sensory integration analogous vertebrate piriform cortex. The were reversibly abolished by...
Odorants are represented as spatiotemporal patterns of spikes in neurons the antennal lobe (AL; insects) and olfactory bulb (OB; vertebrates). These response have been thought to arise primarily from interactions within AL/OB, an idea supported, part, by assumption that receptor (ORNs) respond odorants with simple firing patterns. However, activating AL directly pulses current evoked responses were much less diverse, complex, enduring than elicited odorants. Similarly, models driven...
The lateral horn (LH) of the insect brain is thought to play several important roles in olfaction, including maintaining sparseness responses odors by means feedforward inhibition, and encoding preferences for innately meaningful odors. Yet relatively little known structure function LH neurons (LHNs), making it difficult evaluate these ideas. Here we surveyed >250 LHNs locusts using intracellular recordings characterize their sensory stimuli, dye-fills morphologies, immunostaining...
Neural circuits exploit numerous strategies for encoding information. Although the functional significance of individual coding mechanisms has been investigated, ways in which multiple interact and integrate are not well understood. The locust olfactory system, dense, transiently synchronized spike trains across ensembles antenna lobe (AL) neurons transformed into a sparse representation mushroom body (MB; region associated with memory), provides well-studied preparation investigating...
Four of the five major sensory systems (vision, olfaction, somatosensation, and audition) are thought to use different but partially overlapping sets neurons form unique representations vast numbers stimuli. The only exception is gustation, which represent small basic taste categories. However, using new methods for delivering tastant chemicals making electrophysiological recordings from tractable gustatory system moth Manduca sexta , we found chemical-specific information as follows: (1)...
Inhibitory interneurons play critical roles in shaping the firing patterns of principal neurons many brain systems. Despite difference anatomy or functions neuronal circuits containing inhibition, two basic motifs repeatedly emerge: feed-forward and feedback. In locust, it was proposed that a subset lateral horn (LHNs), provide inhibition onto Kenyon cells (KCs) to maintain their sparse firing—a property for olfactory learning memory. But recently established single inhibitory cell, giant...
Active membrane remodeling during myelination relies on phospholipid synthesis and polarization, both of which are known to depend inositol phospholipids. Here, we show that sciatic nerves mice lacking phosphatidylinositol 4-kinase alpha (PI4KA) in Schwann cells (SCs) substantially reduced myelin thickness with grave consequences nerve conductivity motor functions. Surprisingly, prolonged inhibition PI4KA immortalized mouse SCs failed decrease plasma 4,5-bisphosphate (PI(4,5)P
Biology has inspired solutions to many engineering problems, including chemical sensing. Modern approaches sensing have been based on the biological principle of combining cross-selective sensors with a pattern recognition engine identify odors. Here, we review some recent advances made in mimicking design and computing principles develop an electronic nose. The resulting technology will important applications fundamental research, as well industrial, security, medical domains.
The antennal lobe (AL) is the primary olfactory center in insect brains. It receives sensory input from neurons (OSNs) and sends, through its projection (PNs), reformatted output to secondary centers, including mushroom body (MB) calyx lateral horn (LH) protocerebrum. By injecting dye into AL of wild-type Drosophila, we identified previously unknown direct pathways between ventrolateral, superior medial, posterior protocerebra. We found that most these areas protocerebrum are connected with...