A5081859528- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- MRI in cancer diagnosis
- Urologic and reproductive health conditions
- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Appendicitis Diagnosis and Management
- Orthopedic Infections and Treatments
- Cancer, Lipids, and Metabolism
- Cardiac Imaging and Diagnostics
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Sarcoidosis and Beryllium Toxicity Research
- Head and Neck Cancer Studies
- Dysphagia Assessment and Management
Klinik und Poliklinik für Nuklearmedizin
2017-2025
Essen University Hospital
2020-2025
University Medical Center Hamburg-Eppendorf
2014-2023
Deutschen Konsortium für Translationale Krebsforschung
2021-2023
University of Duisburg-Essen
2021-2023
Universität Hamburg
2013-2022
Martini-Klinik
2019
Eppendorf (Germany)
2017
Klinik und Poliklinik für Neurologie
2016
<sup>18</sup>F-PSMA-1007 PET is used in the management of patients with prostate cancer. However, recent reports indicate a high rate unspecific bone uptake (UBU) <sup>18</sup>F-PSMA-1007, which may lead to false-positive diagnosis. UBU has not been evaluated thoroughly. Here, we evaluate frequency and metastases separately for <sup>68</sup>Ga-PSMA-11 biochemical recurrence (interindividual comparison). Additionally, investigate seen through follow-up examinations (intraindividual...
The ecosystem of brain tumors is considered immunosuppressed, but our current knowledge may be incomplete. Here we analyzed clinical cell and tissue specimens derived from patients presenting with glioblastoma or nonmalignant intracranial disease to report that the cranial bone (CB) marrow, in juxtaposition treatment-naive tumors, harbors active lymphoid populations at time initial diagnosis. Clinical anatomical imaging, single-cell molecular immune profiling quantification tumor reactivity...
Abstract With the rapid expansion of robot-assisted surgical procedures, need for robot-compliant image guidance technologies has also increased. Examples hereof are integrated firefly fluorescence camera, drop-in ultrasound probe, and recently introduced DROP-IN gamma probe. Combined with 68 Ga–prostate-specific membrane antigen–(PSMA)–11 PET/CT (staging) 99m Tc-PSMA-I&S SPECT/CT (preoperative imaging), latter probe technology allowed us to perform first clinical cases PSMA-guided...
For patients with Merkel cell carcinoma (MCC) who are refractory to immune checkpoint inhibition (ICI), treatment options limited. Few cases of MCCs have been reported show responses peptide receptor radionuclide therapy (PRRT). A combination PRRT and ICI has not in MCC date. patient metastatic MCC, was resistant first-line avelumab acquired resistance ipilimumab/nivolumab (IPI/NIVO) additional radiotherapy, presented multiple distant metastases. After confirmation SSTR expression, continued...
Our objective was to compare the ability detect histopathologically confirmed lymph node metastases by early and delayed [99mTc]Tc-PSMA-I&S SPECT/CT in biochemically recurrent prostate cancer. Methods: We retrospectively analyzed 222 patients selected for radioguided surgery using at different time points after injection (≤4 h >15 h). In total, 386 prostate-specific membrane antigen (PSMA) PET predetermined lesions were on a 4-point scale, results compared between late imaging groups, with...
[68Ga]-tetraazacyclododecanetetraacetic acid (DOTA)-conjugated positron emission tomography (PET) is widely used to identify meningiomas due their high expression of somatostatin receptor type 2 (SSTR2). However, recent evidence suggests that this tracer may also show uptake in high-grade gliomas, raising concerns about its diagnostic specificity. The current study presents a challenging case 56-year-old man who was initially diagnosed with right temporal glioblastoma. Follow-up imaging...
<h3>BACKGROUND:</h3> The value of computed tomography (CT) the chest in management patients with ARDS is poorly defined. aim this study was to assess clinical utility thoracic CT scans subjects using Berlin definition. <h3>METHODS:</h3> This a retrospective, observational university hospital center on all whom scan performed immediately before or during an ICU stay between January 1, 2007 and June 30, 2013. <h3>RESULTS:</h3> During period, total 1,781 were performed, which 204 cases met...
We analyzed the diagnostic performance of prostate-specific membrane antigen (PSMA) PET/CT and dosimetry, efficacy, safety
The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are small lipid molecules with a variety of physiological roles. Additionally, their involvement in the initiation progression malignant tumors has been increasingly recognized recent years. However, data on expression S1P LPA receptors different cancer cells very few. Real-time polymerase chain reaction was used for analysis mRNA five S1P((1-5)) three LPA((1-3)) large panel 13 colon, breast, melanoma, lung...
Reactive lymphadenopathy with increased 18F-Fluordeoxyglucose uptake in positron emission tomography/computed tomography scans is known after mRNA vaccination (BNT162B2, mRNA-1273) against severe acute respiratory syndrome coronavirus type 2. Besides this, the thymus might occur as shown our case of a young patient mantle cell lymphoma. Especially patients lymphoma but also other cancer it critical to distinguish between immune responses and involvement disease avoid inadequate treatment decisions.
Paravertebral extramedullary hematopoietic masses (EHMs) account for up to 15% of pseudotumors in beta-thalassemia (BT) and are most likely related compensatory hematopoiesis. In cases, incidentally detected, as the majority patients asymptomatic. Since June 2020, luspatercept is approved treatment with BT who require regular red blood cell transfusions. Data addressing safety efficacy BT-associated EHMs pending. To date (May 2022), paravertebral were observed two asymptomatic out currently...
PSMA PET/CT is the recommended imaging test in cases with prostate-specific antigen (PSA) recurrence after primary therapy of prostate cancer (PCa). However, protocols remain a topic active research. The aim presented study was to examine impact additional late scans pelvis [68 Ga]Ga-PSMA-I&T patients rising PSA prostatectomy.A total 297 (median 0.35 ng/ml, interquartile range (IQR) 0.2-0.8) who underwent early whole-body dose 141 MBq, IQR 120-163; median 86 min, 56-107) and 180 170-191)...
PSMA PET/CT has unprecedented accuracy for localization of initial or recurrent prostate cancer (PC), which can be applied in a metastasis-directed therapy approach. (PET) also role the selection patients radioligand and assessment CRPC patients. The purpose this multicenter retrospective study was to determine incidence bone-only metastasis who underwent restaging, as well identifying potential predictors PET positivity. analyzed data from 179 two centers Essen Bologna. Results showed that...
3064 Background: Fibroblast activation protein (FAP) is expressed at high levels on tumor associated fibroblasts. FAP-directed radioligand positron-emission-tomography (FAP-PET) a novel diagnostic tool for cancer. However, we currently do not understand the performance of FAP-PET as compared to standard FDG-PET. Here aim compare detection by FDG- vs. with independent validation discrepant findings. Methods: Patients (a) proven or suspected malignancy, (b) longest diameter >1 cm, (c)...