A5036783314- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Tracheal and airway disorders
- Sepsis Diagnosis and Treatment
- Esophageal and GI Pathology
- Family and Patient Care in Intensive Care Units
- Cardiac Structural Anomalies and Repair
- Solar and Space Plasma Dynamics
- earthquake and tectonic studies
- Heart Failure Treatment and Management
- Thermal Regulation in Medicine
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Ionosphere and magnetosphere dynamics
- Healthcare cost, quality, practices
- Ultrasound in Clinical Applications
- COVID-19 Clinical Research Studies
- Medical Practices and Rehabilitation
- Seismology and Earthquake Studies
- Astro and Planetary Science
- Dysphagia Assessment and Management
German Respiratory Society
2024
St. Franziskus Hospital
2016-2023
Universität Hamburg
2011-2022
University Medical Center Hamburg-Eppendorf
2011-2022
Martini-Klinik
2017
Policlinico Umberto I
2016
German Society of Medical Intensive Care and Emergency Medicine
2015
Pfizer (United Kingdom)
2014
Thermo Fisher Scientific (Lithuania)
2014
Leibniz Institute for Astrophysics Potsdam
2012-2014
Pre-clinical and autopsy studies have fueled the hypothesis that a dysregulated vascular endothelium might play central role in pathogenesis of ARDS multi-organ failure COVID-19.To comprehensively characterize quantify microvascular alterations patients with COVID-19.Hospitalized adult moderate-to-severe or critical COVID-19 (n = 23) were enrolled non-consecutively this prospective, observational, cross-sectional, multi-center study. Fifteen healthy volunteers served as controls. All...
Abstract Introduction Critically ill patients with respiratory failure undergoing bronchoscopy have an increased risk of hypoxaemia-related complications. Previous studies shown that in awake, hypoxaemic non-invasive ventilation (NIV) is helpful preventing gas exchange deterioration during bronchoscopy. An alternative and increasingly used means oxygen delivery its application via high-flow nasal cannula (HFNC). This study was conducted to compare HFNC NIV acute flexible Methods Prospective...
Background: Autopsy is an important educational and quality-control tool in the intensive care unit (ICU), but rates of traditional medical autopsies have declined worldwide. "Virtual" autopsy involving only advanced radiographic techniques might provide alternative approach to postmortem examinations. Objective: To assess value multidetector computed tomography as autopsy. Design: Prospective cohort study. (ClinicalTrials.gov registration number: NCT01040520) Setting: 9 ICUs a single...
Sepsis is a serious disease condition and major cause of intensive care unit (ICU) admission. Its diagnosis in critically ill patients complicated. To diagnose an infection rapidly, to accurately differentiate systemic inflammatory response syndrome (SIRS) from sepsis, challenging yet early vital for induction appropriate therapy. The aim this study was evaluate whether the immature granulocyte (IG) count useful diagnostic marker sepsis compared other markers. Therefore, total 70 consecutive...
<h3>BACKGROUND:</h3> Critically ill patients with respiratory failure undergoing intubation have an increased risk of hypoxemia-related complications. Delivering oxygen via a high-flow nasal cannula (HFNC) has theoretical advantages and is increasingly used. This study was conducted to compare HFNC bag-valve-mask (BVM) for preoxygenation assess oxygenation during in subjects hypoxemic failure. <h3>METHODS:</h3> randomized controlled trial including 40 critically who received either or BVM...
Background: This study was conducted to determine the effect of hypothermic temperature control after in-hospital cardiac arrest (IHCA) on mortality and functional outcome as compared with normothermia. Methods: An investigator initiated, open-label, blinded-outcome-assessor, multicenter, randomized controlled trial comparing (32-34°C) for 24 h normothermia IHCA in 11 hospitals Germany. The primary endpoint all-cause 180 days. Secondary end points included favorable using Cerebral...
SEPServer is a three-year collaborative project funded by the seventh framework programme (FP7-SPACE) of European Union. The objective to provide access state-of-the-art observations and analysis tools for scientific community on solar energetic particle (SEP) events related electromagnetic (EM) emissions. will eventually lead better understanding acceleration transport processes at Sun in inner heliosphere. These SEP that form one key elements space weather. In this paper we present first...
Since the overall prognosis of very elderly patients is generally limited, admissions to intensive care in these are often restricted. Therefore, only few information available on nonagenarians after treatment. The aim this study was analyze clinical characteristics and outcomes (≥90 years) admitted an unit (ICU). Monocentric, retrospective observational all aged ≥90 years Department Intensive Care Medicine with a total capacity 132 ICU beds at University Medical Center Hamburg Germany...
The aim of this study is to describe the in vitro adsorption anti-infective drugs onto an extracorporeal cytokine adsorber.Various (β-lactams, quinolones, aminoglycosides, glycopeptides, azole antimycotics) were prepared normal saline 0.9% and human albumin 5%, pumped through a cartridge (CytoSorb®; CytoSorbents Corporation, Monmouth Junction, NJ, USA) at flow rate 1.2 L/h for 1.5 h. In addition, meropenem ciprofloxacin dissolved reconstituted blood run CytoSorb cartridge, which was...
Severe COVID-19 induced acute respiratory distress syndrome (ARDS) often requires extracorporeal membrane oxygenation (ECMO). Recent German health insurance data revealed low ICU survival rates. Patient characteristics and experience of the ECMO center may determine intensive care unit (ICU) survival. The current study aimed to identify factors affecting patients.673 ARDS patients treated in 26 centers between January 1st 2020 March 22nd 2021 were included. Data on clinical characteristics,...
The question of whether cancer patients with severe respiratory failure benefit from veno-venous extracorporeal membrane oxygenation (vv-ECMO) remains unanswered. We, therefore, analyzed clinical characteristics and outcomes a large cohort treated vv-ECMO the aim to identify prognostic factors. 297 19 German Austrian hospitals who underwent between 2009 2019 were retrospectively analyzed. A multivariable cox proportional hazards analysis for overall survival was performed. In addition,...
Zusammenfassung Die Anzahl tracheotomierter dysphagischer PatientInnen im klinischen und außerklinisch-ambulanten Setting der damit einhergehende Behandlungsbedarf steigen kontinuierlich. Neufassung Richtlinie des Gemeinsamen Bundesausschusses über die Verordnung außerklinischer Intensivpflege (AKI) sieht zudem vor, dass in AKI regelmäßig evaluiert werden, um Therapiepotenzial nach stationärer Entlassung zu erkennen fördern. Eine besondere Rolle nimmt dabei Dysphagietherapie ein, da ohne...
Noninvasive ventilation (NIV) is a standard procedure in selected patients with acute respiratory failure. Previous studies have used noninvasive to ensure adequate gas exchange during fiberoptic bronchoscopy spontaneously breathing hypoxemic patients, thus avoiding endotracheal intubation. However, it unknown whether can be performed safely failure already need of NIV prior the decision for bronchoscopy.We prospectively investigated 40 consecutive, critically ill, adult (14 women, 26 men,...
Abstract Background There is scarce evidence on the feasibility, safety and resource utilisation of active mobilisation in critically ill patients extracorporeal life support (ECLS). Methods This prospective observational single-centre study included all consecutive ECLS admitted to an academic centre Germany over a time period one year. The level was categorised according ICU Mobility Scale (IMS). Primary outcome complications during mobilisation. Results During period, with activity IMS ≥...
The aim of the study was to describe population pharmacokinetics (PK) meropenem in critically ill patients receiving sustained low-efficiency dialysis (SLED). Prospective PK on 19 septic treated with and SLED for acute kidney injury. Serial blood samples determination concentrations were taken before, during after up three sessions per patient. Nonparametric analysis Monte Carlo simulations used. Pharmacodynamic (PD) targets 40% 100% time above minimal inhibitory concentration (f T > MIC)...