A5035519171- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Immunotherapy and Immune Responses
- Biochemical and Structural Characterization
- vaccines and immunoinformatics approaches
- CAR-T cell therapy research
Radboud University Nijmegen
2020-2022
Radboud Institute for Molecular Life Sciences
2020-2022
Radboud University Medical Center
2020-2022
Functionalized antibodies and antibody fragments have found applications in the fields of biomedical imaging, theranostics, antibody–drug conjugates (ADC). In addition, therapeutic theranostic approaches benefit from possibility to deliver more than one type cargo target cells, further challenging stochastic labeling strategies. Thus, bioconjugation methods reproducibly obtain defined homogeneous bearing multiple different molecules, without compromising affinity, are demand. Here, we...
Type 1 conventional dendritic cells (cDC1s) are characterized by their ability to induce potent CD8+ T cell responses. In efforts generate novel vaccination strategies, notably against cancer, human cDC1s emerge as an ideal target deliver antigens. uniquely express XCR1, a seven transmembrane G protein-coupled receptor. Due its restricted expression and endocytic nature, XCR1 represents attractive receptor mediate antigen-delivery cDC1s. To explore tumor antigen delivery cDC1s, we used...
I. Abstract Functionalized antibodies and antibody fragments have found applications in the fields of biomedical imaging, theragnostics, antibody-drug conjugates (ADC). Antibody functionalization is classically achieved by coupling payloads onto lysine or cysteine residues. However, such stochastic strategies typically lead to heterogenous products, bearing a varying number payloads. This affects bioconjugate efficacy stability, as well its vivo biodistribution, therapeutic index, while...
ABSTRACT Type 1 conventional dendritic cells (cDC1s) are characterized by their ability to induce potent CD8 + T cell responses. In efforts generate novel vaccination strategies, notably against cancer, human cDC1s emerge as an ideal target deliver antigens. uniquely express XCR1, a seven transmembrane G protein-coupled receptor (GPCR). Due its restricted expression and endocytic nature, XCR1 represents attractive mediate antigen-delivery cDC1s. To explore tumor antigen delivery cDC1s, we...