A5073909514- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Microbial Natural Products and Biosynthesis
- Bacterial Genetics and Biotechnology
- Ion Transport and Channel Regulation
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Adipose Tissue and Metabolism
- Acute Lymphoblastic Leukemia research
- Cellular transport and secretion
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- Immune Cell Function and Interaction
- Sensor Technology and Measurement Systems
- Protist diversity and phylogeny
- Erythrocyte Function and Pathophysiology
- Protein Structure and Dynamics
European Molecular Biology Laboratory
2017-2020
Instituto Gulbenkian de Ciência
2011
Abstract The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable for molecular biology community investigating functional regions in many proteins. In this update, we have added 21 novel classes, made major revisions to 12 classes and >400 new instances mostly focused on DNA damage, cytoskeleton, SH2-binding phosphotyrosine mimicry by...
Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs short, often highly degenerate, difficult to characterize and hard detect. The eukaryotic motif (ELM) resource (elm.eu.org) is dedicated SLiMs, consisting of a manually curated database over 275 classes 3000 instances, pipeline discover candidate sequences. For 15 years, ELM has been one the resources for research. In this update, we present latest additions including 32 new...
Rab proteins are small GTPases that act as essential regulators of vesicular trafficking. 44 subfamilies known in humans, performing specific sets functions at distinct subcellular localisations and tissues. function is conserved even amongst distant orthologs. Hence, the annotation Rabs yields functional predictions about cell biology So far, annotating has been a laborious manual task not feasible for current future genomic output deep sequencing technologies. We developed, validated...
Abstract The Eukaryotic Linear Motif (ELM) resource is dedicated to the characterization and prediction of short linear motifs (SLiMs). SLiMs are compact, degenerate peptide segments found in many proteins essential almost all cellular processes. However, despite their abundance, remain largely uncharacterized. ELM database a collection manually annotated SLiM instances curated from experimental literature. In this article we illustrate how browse search for data, cover different types data...