Ayşe Şi̇mşek

ORCID: 0000-0001-9250-078X
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About
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Research Areas
  • Autoimmune and Inflammatory Disorders Research
  • Immune Cell Function and Interaction
  • Tumors and Oncological Cases
  • Cardiovascular Function and Risk Factors
  • Congenital heart defects research
  • Connective tissue disorders research
  • Dermatological and Skeletal Disorders
  • Genetics and Neurodevelopmental Disorders
  • Cardiac Imaging and Diagnostics
  • Vascular Tumors and Angiosarcomas
  • Oral and gingival health research
  • Cardiac electrophysiology and arrhythmias
  • Sarcoma Diagnosis and Treatment
  • Genomic variations and chromosomal abnormalities
  • Hemophilia Treatment and Research
  • Family and Disability Support Research
  • Platelet Disorders and Treatments
  • Inflammasome and immune disorders

Necmettin Erbakan University
2022-2024

Konya Eğitim ve Araştırma Hastanesi
2024

City Hospital
2024

INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a rare, non-malignant immune regulation disorder characterized by hemophagocytosis. The HLH 2004 study listed the widely accepted diagnostic model, which requires presence of 5 out 8 criteria (Fever; splenomegaly; cytopenia; hypertriglyceridemia or hypofibrinogenemia; hemophagocytosis, ferritin >500 mcg/L; Low/absent NK-cell activity; soluble CD25 elevation). current management guidelines based on HLH-94 studies involve...

10.16899/jcm.1583412 article EN cc-by-nc-nd Journal of Contemporary Medicine 2025-02-26

Intellectual disability is characterized by impairment in at least two of the following areas: social skills, communication self-care tasks, and academic skills. These impairments are evaluated relation to expected standards based on individual’s age cultural levels. Additionally, intellectual typically defined a measurable level functioning, represented an intelligence quotients core 70 or below. Autism spectrum disorder developmental resulting from differences brain, often problems...

10.1097/ypg.0000000000000368 article EN Psychiatric Genetics 2024-04-20

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease, with high mortality if left untreated. In addition, the disease has unique diagnostic challenges. Therefore, despite existing guidelines on management, current clinical practice data informative course and outcome. Herein, retrospective chart review study was conducted through collaboration of six centers, located in central southeastern Türkiye. The demographical data, laboratory results, treatment outcomes were...

10.1007/s00277-024-06087-y article EN cc-by-nc-nd Annals of Hematology 2024-11-23

Giriş: Granülositik sarkom (GS) granülositik prekürsör hücrelerin ekstramedüller yayılımından kaynaklanan lokalize bir tümördür ve literatürde; chloroma, monositik sarkom, myeloid myeloblastom, hücreli tümör olarak da adlandırılmaktadır. Genellikle kemik, periost, yumuşak doku, lenf nodları veya deride olur. En yaygın paranazal sinüsler orbita etkilenir. GS ayrıca akut miyeloid löseminin nadir başlangıç prezentasyonudur. Olgu: Bu olgumuzda bacak ağrısı üst solunum yolu enfeksiyonu...

10.61745/jsmsau.1375162 article TR Atatürk Üniversitesi Tıp Fakültesi Cerrahi Tıp Bilimleri Dergisi 2023-12-29

10.5152/akd.2012.106 article EN cc-by-nc Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology 2012-04-01

Amaç: Diş hekimleri hastalarının genel sağlık durumlarıyla ilgili oluşan pek çok değişikliğin içerisinde olan çalışanlarıdır. Bu çalışmanın amacı, pulpal-periapikal patoloji ve hemofili hastalığının olası ilişkisini araştırmaktır. Gereç Yöntemler: Kliniğimize başvurmuş olan, sistemik olarak Hemofili A B hastalığı dışında başka bir olmayan, teşhis amaçlı panoramik ve/veya periapikal radyografı alınmış 3-16 yaş arasındaki bireylerin ağız içi muayeneleri yapılarak çürüklü, çekilmiş dolgulu diş...

10.51122/neudentj.2022.48 article TR Necmettin Erbakan Universitesi Dis Hekimligi Dergisi (NEU Dent J) Necmettin Erbakan 2022-12-31

Type 1 Diabetes mellitus (DM) is associated with the development of cardiovascular disease. In this study we aimed to determine left atrial function two-dimensional speckle tracking echocardiography (2D-STE) and identify cardiac autonomic dysfunction P wave analysis in pediatric patients Mellitus (DM). 63 36 healthy controls were included study. Conventional transthoracic echocardiography, 2D-STE, 12-lead surface electrocardiography performed all patients. The LA strain (LA S) parameters:...

10.20515/otd.979540 article EN OSMANGAZİ JOURNAL OF MEDICINE 2021-09-15
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