Abstract Herein, we report a simple, efficient, and sustainable method for the synthesis of α‐alkylated ketones quinolines using hydrogen‐borrowing strategy, which has emerged as greener alternative in organic transformation reactions. Synthesis range quinoline derivatives was achieved by water‐soluble [Ru(8‐AQ)Cl(p‐cym.)] + Cl − [Ru]‐1 (AQ=aminoquinoline) catalyst with water reaction medium. By adopting this have synthesized or secondary alcohols starting materials primary alcohol green...

Oxidative coupling of benzylamines and alcohols with methyl substituted N-heteroarenes such as quinolines quinoxalines has been achieved using chloride, a sea abundant anion the catalyst for practical synthesis wide range E-disubstituted olefins in aqueous medium. Detailed mechanistic studies control experiments were carried out to deduce reaction mechanism which indicated that situ formed ClO2- is active form catalyst. We have successfully 1 g scale this methodology, five pharmaceutically...

Herein, we report a new air-stable phosphine-free 8-AQ (8-aminoquinoline) based Mn(I) carbonyl complex as the catalyst for C(α)-alkylation of oxindoles with alcohols. The Mn [(8-AQ)Mn(CO)3 Br] works effectively α-alkylation by both secondary well primary procedure has been used synthesis pharmaceutically important recently developed such 3-(4-methoxybenzyl)indolin-2-one, 3-(4-(dimethylamino)benzyl)indolin-2-one, 3-(4-(dimethylamino)phenyl)-5-fluoroindolin-2-one and...

The in situ generated aminodiborane (μ-NH 2 B H 5 ) using NH 3 BH and elemental iodine (I is used for the reduction of carboxamides to amines.

Herein, we report an efficient methodology for the reduction of esters, carbonates, and anhydrides to alcohols using in situ generated aminodiborane from iodine ammonia borane. This also finds use transformation esters iodides by varying stoichiometry reagents. The protocol has broad substrate scope with excellent yields. method is useful synthesizing pharmaceutically industrially important compounds such as a Cinacalcet precursor, Streptoindole analogue, 1,4-pentanediol. Control studies DFT...

Abstract Herein, we report an efficient and sustainable manganese‐catalyzed α‐C−H bond alkylation methodology to synthesize branched sulfones via a hydrogen borrowing pathway. The air‐stable phosphine‐free Mn‐catalyst, (NNN)Mn(II)Cl 2 was synthesized by using earth‐abundant, commercially available, inexpensive precursor MnCl .4H O, stable NNN pincer i. e. [N‐((benzimidazole‐2‐yl)methyl)quinoline‐8‐amine] ligand system. Taking benzyl phenyl as substrates, alcohol derivatives alkylating...

Herein, we report a palladium-catalyzed 'on-water' methodology for the synthesis of biaryl and m-teraryl derivatives aryl carboxamides by selective mono bis C-H bond functionalization. 8-aminoquinoline 2-thiomethylaniline were used as directing groups functionalization with various alkyl iodides using 3.0-4.0 mol% Pd(OAc)2 catalyst water solvent resulting in 45-97% isolated yields functionalized products. Using an carboxamide core, indole-3-carboxylic acid late-stage aspirin molecule have...

Abstract γ‐Valerolactone (GVL), an industrially important compound and green‐solvent was synthesized using a metal‐free method by I 2 /Et 3 SiH directly from levulinic acid at room temperature in good yield. Different types of keto‐acids were also subjected to this methodology synthesize the corresponding lactones. A 2‐gram scale reaction successfully carried out Control experiments indicated that situ generated Et SiI is active catalyst for reaction.

Abstract New water soluble neutral and cationic palladium complexes were synthesized using 8‐aminoquinoline (8‐AQ) 2‐methyl (2‐Me 8‐AQ) ligands their catalytic properties evaluated. The trimeric having a Pd 3 N core found to form when Pd(OAc) 2 was reacted with 8‐AQ or 2‐Me irrespective of the stoichiometry between reagents. Controlled addition triflic acid complex resulted in formation as well monomeric complex. A two units 2‐Me‐8AQ ligand also from Crystal structures new are reported this...