A5087181801- Bioactive natural compounds
- 3D Printing in Biomedical Research
- Infant Health and Development
- Barrier Structure and Function Studies
- Advancements in Transdermal Drug Delivery
- Hydrogels: synthesis, properties, applications
- Drug Solubulity and Delivery Systems
- Gut microbiota and health
- Curcumin's Biomedical Applications
- Graphene and Nanomaterials Applications
- Nail Diseases and Treatments
- Global Cancer Incidence and Screening
- Medicinal Plants and Neuroprotection
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Gastric Cancer Management and Outcomes
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Colorectal Cancer Treatments and Studies
- Nonmelanoma Skin Cancer Studies
- Child Nutrition and Feeding Issues
Guru Nanak Dev University
2019-2024
This study aimed to develop microsponges based topical gel formulation of 5-Fluorouracil (5-FU) for the treatment skin cancer with enhanced deposition and reduced irritation potential. Microsponges were prepared by Quasi-emulsion solvent diffusion method using ethyl cellulose Eudragit RL 30 D; was optimised through detailed in vitro characterisation. Brunauer-Emmett-Teller (BET) analysis demonstrated higher surface area (2.4393 m2/g) pore volume developed formulation. Optimised showed better...
The brain is a delicate organ and targeting neurological diseases with conventional approaches still daunting task. This due to the presence of necessary physiological barriers, mainly blood-brain barrier, that blocks entry dangerous poisonous substances from bloodstream, thus helping in maintaining homeostasis. Furthermore, multidrug resistance transporters which act by prohibiting drugs across cell membrane channelizing them outside environment another defense mechanism. Despite...
Abstract Pazopanib hydrochloride (PZH) is a Biopharmaceutics Classification System class II drug that faces challenges at the formulation forefront including low aqueous solubility (0.043 mg/mL) and poor oral bioavailability (14–39%). The present investigation aimed to develop self‐microemulsifying delivery system (SMEDDS) of PZH using blend Capryol® 90, Labrasol®, propylene glycol improve its solubility. Furthermore, sustained‐release SMEDDS‐based gastroretentive floating was developed...
Cancer is a worldwide health ailment with no known boundaries in terms of mortality and occurrence rates, thus one the biggest threats to humankind. Hence, there an absolute need develop novel therapeutics bridge infirmities associated chemotherapy conventional surgical methodologies, including impairment normal tissue, compromised drug efficiency escalation side effects. In lieu this, has been surge curiosity towards development injectable hydrogels for cancer therapy because local...