A5013292423- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Neuroscience of respiration and sleep
- Anesthesia and Sedative Agents
- Hepatitis B Virus Studies
- Frailty in Older Adults
- Neonatal Respiratory Health Research
- Neonatal Health and Biochemistry
- Hepatitis C virus research
- Enhanced Recovery After Surgery
- Pneumonia and Respiratory Infections
- Adenosine and Purinergic Signaling
- Electrolyte and hormonal disorders
- Respiratory Support and Mechanisms
- Hip and Femur Fractures
- Potassium and Related Disorders
- Liver Disease Diagnosis and Treatment
- Membrane-based Ion Separation Techniques
- HIV Research and Treatment
- Pharmaceutical Practices and Patient Outcomes
- Head and Neck Surgical Oncology
- Medical Practices and Rehabilitation
- Calcium signaling and nucleotide metabolism
- Viral gastroenteritis research and epidemiology
University Medical Center Hamburg-Eppendorf
2013-2025
Universität Hamburg
2013-2025
St George Hospital
2024
Rotkreuzklinikum München
2019
Leibniz Institute of Virology (LIV)
2006-2009
Hallym University
2006
University of Ulsan
2006
Ulsan College
2006
Inje University
2006
The reverse-transcriptase inhibitor lamivudine (Zeffix, GlaxoSmithKline) is often used to treat chronic infection with hepatitis B virus (HBV) until resistance develops. Treatment may then be switched the adefovir (Hepsera, Gilead), which has a lower frequency of resistance. Here, we describe three cases primary that were sensitive tenofovir (Viread, Gilead). All involved rare HBV variant valine at position 233 domain instead isoleucine (rtI233V), as in wild-type virus. This also displayed...
Hip fracture surgery is associated with high in-hospital and 30-day mortality rates serious adverse patient outcomes. Evidence from randomised controlled trials regarding effectiveness of spinal versus general anaesthesia on patient-centred outcomes after hip sparse.
Abstract Background Number of drugs are increasing with older age and present a risk factor for various adverse health outcomes. A comprehensive medication therapy management (MTM) before admission elective surgery may help reduce unnecessary potentially inadequate medications (PIM) thus improve patient health. Our goal was to evaluate the implementation PHAROS, perioperative MTM intervention study, from perspective care providers. The PHAROS aimed appropriateness in inpatients at outpatient...
It remains unknown whether there is a causal relationship between intraoperative hypotension and postoperative neurocognitive disorders. We tested the hypothesis that personalised-compared to routine-intraoperative blood pressure management reduces incidence of disorders in patients having major noncardiac surgery.
Abstract In adult respiratory distress syndrome (ARDS) pulmonary perfusion failure increases physiologic dead-space (V D /V T ) correlating with mortality. High V results in alveolar hypocapnia, which has been demonstrated to cause edema formation, atelectasis, and surfactant depletion, evoked, at least part, by apoptosis of epithelial cells (AEC). However, the mechanism underlying hypocapnia-induced AEC is unknown. Here, using fluorescent live-cell imaging cultured type 2 we could show that...
Background In acute respiratory distress syndrome (ARDS), pulmonary perfusion failure increases physiologic dead space ventilation (V D /V T ), leading to a decline of the alveolar CO 2 concentration [CO ] iA . Although it has been shown that hypocapnia contributes formation atelectasis and surfactant depletion, typical complication in ARDS, underlying mechanism not elucidated so far. Methods isolated perfused rat lungs, cytosolic or mitochondrial Ca 2+ concentrations ([Ca cyt [Ca mito ,...
ABSTRACT Recently, we reported on three patients with chronic hepatitis B virus (HBV) infection for whom adefovir (ADF) therapy virologically failed, most likely due to a preexisting rtI233V HBV polymerase mutation. Here, describe two further who were found develop the mutation after initiation of ADF therapy. These represent first cases known so far in which resistance evolved under persistent replication during ADF. Interestingly, one previously described patients, was initially...
Maintaining functional status is an essential therapeutic goal in peri-operative care of older adults. Although several recommendations concerning management are available, pragmatic approaches to their sustainable implementation lacking. Multiple evidence-based for adults were bundled into a multicomponent intervention and assessed feasibility effectiveness. A quality improvement study with before-after comparison using hybrid implementation-effectiveness approach. University Medical...
Bacterial pneumonia is a global health challenge that causes up to 2 million deaths each year. Purinergic signaling plays pivotal role in healthy alveolar epithelium. Here, we used fluorophore-based analysis and live-cell calcium imaging address the question of whether bacterial pathogen Streptococcus pneumoniae directly interferes with purinergic epithelial cells. Disturbed might result pathophysiologic changes like edema formation atelectasis, which are commonly seen pneumonia. Purine...
Introduction Geriatric patients have a pronounced risk to suffer from postoperative complications. While effective risk-specific perioperative measures been studied in controlled experimental settings, they are rarely found routine healthcare. This study aims (1) implement multicomponent preoperative and intraoperative intervention, investigate its feasibility, (2) exploratorily assess the effectiveness of intervention Methods analysis Feasibility exploratory will be investigated...
In elderly patients following surgery, postoperative delirium (POD) is the most frequent complication and associated with negative outcomes. The 2017 European Society of Anaesthesiology guideline on POD aims to improve patient care by implementing structured prevention, diagnosis treatment. However, these recommendations, especially systematic screening, are still incompletely adopted in clinical practice. aim this study was evaluate feasibility acceptance validated screening tools identify...
With increasing age, the risk of complications after surgery rises in elderly patients. Furthermore, prevalence multimorbidity and polypharmacy with making this population especially vulnerable for drug-related problems posing an additional postoperative complications. Still, only few studies have concentrated on investigating how medication safety can be improved these The aim pilot study is to examine impact a comprehensive intervention (interprofessional systematic therapy management)...