A5103075583- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Bacillus and Francisella bacterial research
- Monoclonal and Polyclonal Antibodies Research
- Influenza Virus Research Studies
- HIV/AIDS Research and Interventions
- Vibrio bacteria research studies
Rockefeller University
2018-2020
Abstract Novel therapeutic and preventive strategies are needed to contain the HIV-1 epidemic. Broadly neutralizing human antibodies (bNAbs) with exceptional activity against currently being tested in prevention trials. The selection of anti-HIV-1 bNAbs for clinical development was primarily guided by their vitro Env pseudotyped viruses. Here we report on 9 now 126 Clade A, C, D PBMC-derived primary African isolates. potency breadth significantly reduced compared viruses panels. difference...
Abstract The role of lymphoid tissue as a potential source HIV-1 rebound following interruption antiretroviral therapy is uncertain. To address this issue, we compared the latent viruses obtained from CD4 + T cells in peripheral blood and lymph nodes to emerging during treatment interruption. Latent were characterized by sequencing near full-length (NFL) proviral DNA, env viral outgrowth cultures (VOAs). 5 infected individuals on (ART) studied, 4 whom participated clinical trial that...