A5088350978- Crystallization and Solubility Studies
- Pharmaceutical Economics and Policy
- Drug Solubulity and Delivery Systems
- X-ray Diffraction in Crystallography
- Blood Pressure and Hypertension Studies
- Pharmacogenetics and Drug Metabolism
- Powder Metallurgy Techniques and Materials
- Computational Drug Discovery Methods
- Crystallography and molecular interactions
- Gout, Hyperuricemia, Uric Acid
- Metal-Organic Frameworks: Synthesis and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Medical Device Sterilization and Disinfection
- Biosimilars and Bioanalytical Methods
- Eosinophilic Disorders and Syndromes
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Pharmacological Effects of Natural Compounds
- Pharmaceutical Practices and Patient Outcomes
- Process Optimization and Integration
- Crystal structures of chemical compounds
- Medicinal plant effects and applications
- Analytical Methods in Pharmaceuticals
- Healthcare Systems and Public Health
- Therapeutic Uses of Natural Elements
Exact Sciences (United States)
2023
Exact Dynamics (Netherlands)
2022
Peoples' Friendship University of Russia
2016-2019
Introduction. Gout treatment drugs are widely represented on the pharmaceutical market of Russian Federation, including those with INN febuxostat. These differ in excipients composition, dosage form (tablets and capsules) production technology. The Dissolution Kinetics Test was chosen to assess rate extent active ingredient release for febuxostat different manufacturers as vitro test dissolution allows suggest from vivo. percent substance factors that have a direct impact bioavailability...
AIM. To measure the trough and maximum plasma concentrations of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) patients on standard reduced doses drugs, to evaluate impact TKI concentration loss major/deep molecular response (MR) after dose reduction drug toxicity changes. MATERIALS & METHODS. The trial enrolled 46 imatinib 16 nilotinib recipients. (Сtrough) (Cmax) were measured. On imatinib/nilotinib therapy, Ctrough was analyzed 104/22 Cmax 63/15 samples,...
Introduction. As part of a comparative assessment drugs quality available on the Russian market dissolution profile studies and uniformity dosage units test was conducted for various manufacturers "Captopril" drugs. Drug release in three media (0.1 M hydrochloric acid, acetate buffer pH 4.5, phosphate 6.8) with sampling at 0, 5, 10, 15, 20, 30 min analysis using UV/Vis spectrophotometer 212 nm were conducted. Dissolution kinetics compared based calculation similarity factor f 2 values...
Abstract The crystal structures of 6-methyl-2-ethyl-3-hydroxypyridiniun nitrate (C 8 H 12 NO)NO 3 ( I ) and fumarate NO) 2 C 4 O II were solved refined from X-ray single diffraction data (CuKα, a =4.6477(2), b =14.5906(9), c =14.5551(8) Å, β =99.100(4)°, space group P 1 /c , Z=4, R p / wp =0.033/0.047; =8.8293(3), =13.4268(5), =8.3893(3) =96.303(3)°, Z=2, wp= 0.034/0.049). Both are built infinite chains along ac diagonal the unit cells formed by hydrogen bonding between hydroxypyridium...
Introduction. A fixed dose combination of telmisartan and hydrochlorothiazide is indicated for treatment in the arterial hypertension. The these substances causes an additive effect that helps to reduce blood pressure. bioequivalence study Telzap ® Plus compared with MikardisPlus was conducted 63 volunteers. Aim. purpose trial a comparative pharmacokinetics evidence drug product (tablets 80 mg + 12,5 mg, Zentiva KS company, Czech Republic) products (telmisartan+hydrochlorothiazide, tablets...
Introduction. Telmisartan is widely used in clinical practice during hypertension treatment. It a specific angiotensin II receptor antagonist (type AT1), effective at oral intake, A bioequivalence study of Telzap ® and Mikardis was conducted with 60 volunteers. Aim. The purpose the trial comparative pharmacokinetics evidence (telmisartan, tablets 80 mg, Boehringer Ingelheim International GmbH, Germany) Zentiva KS company, Czech Republic) healthy volunteers after single administration under...
Introduction. As a part of the registration drug product bioequivalence study fixed-dose combination "Ezetimibe + rosuvastatin" (JSC "Sanofi-aventis group", Russia) compared with coadministered Ezetrol® (ezetimibe) and Crestor® (rosuvastatin) was conducted 76 healthy volunteers. Enzymatic hydrolysis used to evaluate pharmacokinetics total ezetimibe. This reason for inclusion additional monitored parameters in validation analysis. Aim. The purpose trial comparative evidence (ezetimibe...
Introduction. The advantages of fixed-dose combination losartan + amlodipine rosuvastatin compared to mono-drugs and two-component combinations are increase the therapeutic efficacy, reduce cost product make drug easier take which helps improve patient adherence therapy. A bioequivalence study three-component Losartan Sanofi with coadministered Lozap® AM (Losartan+Amlodipine) Crestor® (Rosuvastatin) was conducted. Aim. purpose trial a comparative pharmacokinetics evidence two strengths...