A5037033848- Hearing, Cochlea, Tinnitus, Genetics
- RNA Research and Splicing
- Circadian rhythm and melatonin
- Impact of Light on Environment and Health
- Hearing Loss and Rehabilitation
- Bat Biology and Ecology Studies
- Genomics and Chromatin Dynamics
- Genetics, Aging, and Longevity in Model Organisms
- Pulmonary Hypertension Research and Treatments
- Phosphodiesterase function and regulation
- Plant Molecular Biology Research
- Urban Green Space and Health
- RNA regulation and disease
- RNA and protein synthesis mechanisms
- Planarian Biology and Electrostimulation
- Adipose Tissue and Metabolism
Utica College
2022
University of Pennsylvania
2015-2021
Tissue- and cell-type-specific regulators of alternative splicing (AS) are essential components posttranscriptional gene regulation, necessary for normal cellular function, patterning, development. Mice with ablation Epithelial regulatory protein (Esrp1) develop cleft lip palate. Loss both Esrp1 its paralog Esrp2 results in widespread developmental defects broad implications to human disease. Deletion the Esrps epidermis revealed their requirement establishing a proper skin barrier, primary...
The mammalian cochlea develops from a ventral outgrowth of the otic vesicle in response to Shh signaling. Mouse embryos lacking or its essential signal transduction components display cochlear agenesis, however, detailed understanding transcriptional network mediating this process is unclear. Here, we describe an integrated genomic approach identify dependent genes and associated regulatory sequences that promote duct morphogenesis. A comparative transcriptome analysis vesicles mouse mutants...
The interneurons ALA and RIS both regulate stress induced sleep in C. elegans but their roles awake animal movement has been reported to differ. We describe the development of a motivated mobility-based assay that distinguishes between animals mutant for function those function.
ABSTRACT The mammalian cochlea develops from a ventral outgrowth of the otic vesicle in response to Shh signaling. Mouse embryos lacking or its essential signal transduction components display cochlear agenesis, however, detailed understanding transcriptional network mediating this process is unclear. Here, we describe an integrated genomic approach identify dependent genes and associated regulatory sequences that promote duct morphogenesis. A comparative transcriptome analysis vesicles...
As human development continues to encroach into natural habitats, artificial light at night (ALAN) has increasingly become a concern for wildlife. Nocturnal animals are especially vulnerable ALAN, as the physiology and behavior of nocturnal species have evolved under conditions associated with predictably dark environments. Studies exposing amphibians constant bright provide evidence changes normal metabolism, growth, behavior, but few these studies used treatments dim ALAN comparable that...