A5008814225- Genomics, phytochemicals, and oxidative stress
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Calcium signaling and nucleotide metabolism
- Plant Stress Responses and Tolerance
- Lysosomal Storage Disorders Research
- Plant Molecular Biology Research
- Sphingolipid Metabolism and Signaling
Peter MacCallum Cancer Centre
2023-2024
The University of Melbourne
2023-2024
Cardiff University
2020
The liver exhibits a remarkable capacity to regenerate following injury. Despite this unique attribute, toxic injury is leading cause of failure. temporal processes by which the senses and initiates regeneration remain unclear. Here, we developed transgenic zebrafish model wherein hepatocyte-specific expression uracil phosphoribosyltransferase (UPRT) enabled implementation SLAM-ITseq investigate nascent transcriptome during initiation regeneration. Using approach, identified rapid metabolic...
The maintenance of redox and metabolic homeostasis is integral to embryonic development. Nuclear factor erythroid 2-related 2 (NRF2) a stress-induced transcription that plays central role in the regulation balance cellular metabolism. Under homeostatic conditions, NRF2 repressed by Kelch-like ECH-associated protein 1 (KEAP1). Here, we demonstrate Keap1 deficiency induces Nrf2 activation postdevelopmental lethality. Loss viability preceded severe liver abnormalities characterized an...
Abstract Lysosomal storage diseases are the most common cause of neurodegeneration in children. They characterised at cellular level by accumulation material within lysosomes. There very limited therapeutic options, and search for novel therapies has been hampered as few good small animal models available. Here, we describe use light sheet microscopy to assess lipid drug morpholino induced zebrafish two cholesterol homeostasis with lysosomal dysfunction: First, Niemann–Pick type C disease...