A5022584363- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Hedgehog Signaling Pathway Studies
- Occupational and environmental lung diseases
- Digestive system and related health
- Bioinformatics and Genomic Networks
- Thyroid Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Helicobacter pylori-related gastroenterology studies
- Cancer-related Molecular Pathways
- Cytokine Signaling Pathways and Interactions
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Tangshan Gongren Hospital
2021-2023
Shandong University
2020
Research shows a higher incidence of colorectal cancer in men. However, the molecular mechanisms for this gender disparity remain unknown. We report roles androgen proliferation and differentiation intestinal stem cells via targeting receptor (AR) on stromal by negatively regulating BMP signaling. Orchidectomy (ORX) or AR antagonist promotes expansion epithelium but suppresses cell (ISC) proliferation. Conversely, agonist inhibits ISC augments ovariectomized mice. Mechanistically, activation...
We aimed to examine the roles of microRNA-873-5p and CXCL5 in thyroid cancer (TC) cells. qRT-PCR was adopted measure expression levels mRNA TC cells, western blot evaluate protein level. Bioinformatics analysis done predict upstream gene CXCL5. Dual-luciferase assay applied validate binding relationship regulatory gene. Cell experiments were detect effects targeting on malignant progression Western demonstrate phosphorylation level P53 pathway related-proteins. upregulated cells tissues. The...
Solute Carrier Family 4 Member (SLC4A4) is a membrane protein‐coding gene for Na+/HCO3− cotransporter and plays crucial role in regulating pH, bicarbonate secretion homeostasis. However, the prognostic immunological of SLC4A4 colon cancer remains unknown. In this study, expression profiles were retrieved from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases, to which variety bioinformatic analyses performed. Sangerbox, Xiantao, ESTIMATE TIMER online tools used delve...
Thyroid cancer (TC) is a common and curable endocrine tumor occurring in the head neck characterized by low mortality rate compared to other malignancies. In this study, immune microenvironment of TC was investigated identify biomarkers. The mRNA clinical data available study were accessed from Cancer Genome Atlas-Thyroid (TCGA-THCA) dataset. Differences infiltration levels normal samples assessed CIBERSORT. classified into high- low-abundance groups according median abundance cell...
Abstract Background Solute Carrier Family 4 Member (SLC4A4) is a membrane protein-coding gene for Na + /HCO 3 − cotransporter and plays crucial role in regulating pH, bicarbonate secretion homeostasis. However, the prognostic immunological of SLC4A4 colon cancer remains unknown. Method In this study, expression profiles were retrieved from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases, to which variety bioinformatic analyses performed. Sangerbox, Xiantao, ESTIMATE...
Thyroid carcinoma is a type of prevalent cancer. Its prognostic evaluation depends on clinicopathological features. However, such conventional methods are deficient. Based mRNA, single nucleotide variants (SNV), and clinical information thyroid from The Cancer Genome Atlas (TCGA) database, this study statistically analyzed mutational signature patients with disease. Missense mutation SNV the most common variant classification type, respectively. Next, tumor burden (TMB) sample was...
Thyroid cancer (TC) is a common endocrine malignancy, comprising nearly one-third of all head and neck malignancies worldwide. MicroRNAs (miRNAs) have been implicated in the malignant progression multiple cancers; however, their contribution to thyroid diseases has not fully explored.This study aimed illustrate regulatory mechanism microRNA-196a-5p TC investigate whether affects cells by targeting low-density lipoprotein receptor-associated protein 1B (LRP1B). MicroRNA-196a-5p LRP1B...
Background: Solute Carrier Family 4 Member (SLC4A4) is a membrane protein‐coding gene for Na+/HCO3− cotransporter and plays crucial role in regulating bicarbonate secretion homeostasis. However, the prognostic immunological of SLC4A4 colon cancer remains unknown.Method: In this study, expression profiles were retrieved from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases, to which variety bioinformatic analyses performed. Sangerbox, Xiantao, ESTIMATE TIMER online tools...