A5086270656- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Plant Molecular Biology Research
- Biomedical and Engineering Education
- RNA and protein synthesis mechanisms
- HIV/AIDS Research and Interventions
- Single-cell and spatial transcriptomics
- Renal and related cancers
- Prenatal Screening and Diagnostics
- Ethics in Clinical Research
KU Leuven
2018-2023
MRC Weatherall Institute of Molecular Medicine
2021
University of Oxford
2021
ABSTRACT The frequent acquisition of genomic abnormalities in human preimplantation embryos is a leading cause pregnancy loss, but does not necessarily prohibit healthy offspring. However, the impact on cellular states and development early embryo remains largely unclear. Here, we characterise aneuploidy reconstruct gene regulatory networks embryos, investigate expression developmental perturbations instigated by using single-cell genome-and-transcriptome sequencing (G&T-seq). At level,...
Abstract With the boom in Genome-Wide Association Studies (GWAS), it has become apparent that many disease-associated genetic variants lie non-coding regions of genome. In order to prioritise these and disentangle their functional significance, is important be able accurately classify cis-regulatory elements within Historically, classification relied purely on presence characteristic histone marks, with recent advancements using more sophisticated Hidden Markov Model (HMM)-based approaches....
Abstract This article is concerned with transdisciplinarity as a framework for addressing the wicked problem of rising HIV drug resistance (HIVDR) rates in Africa and its implications. According to data published by Joint United Nations Programme on HIV/AIDS (UNAIDS), even though number AIDS-related deaths has declined 48% between 2005 2016, this significant decrease now threatened rise antiretroviral drugs several regions, including Africa. Through application transdisciplinary research...
Abstract In this opinion piece we argue for combining data-centered hackathons with transdisciplinarity to better understand wicked problems such as food insecurity. Hackathons represent unique opportunities answering previously identified and consequently well-defined questions in the context of high-dimensional data. However, possibilities providing participants extensive potentially quintessential background knowledge enabling them develop a shared understanding explicit implicit meanings...