A5000683003- Polysaccharides and Plant Cell Walls
- Microbial Metabolites in Food Biotechnology
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Synthesis of Organic Compounds
- Ginkgo biloba and Cashew Applications
- Nanoparticle-Based Drug Delivery
- Chemotherapy-induced organ toxicity mitigation
- Erythrocyte Function and Pathophysiology
- Advanced Nanomaterials in Catalysis
- Pineapple and bromelain studies
- Polysaccharides Composition and Applications
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Seaweed-derived Bioactive Compounds
- Blood properties and coagulation
A.E. Arbuzov Institute of Organic and Physical Chemistry
2020-2025
Kazan Federal University
2020
Based on the method developed in this study for obtaining water-soluble PGKCo and PGNaCo, which we had previously synthesized, a pharmacological composition (PC) containing simultaneously macroelements K Na, as well trace element Co, was obtained first time. The effect of polygalacturonates PC viability cells tumor lines various origins studied vitro. It shown that target products have water solubility, low toxicity (LD50 above 5000 mg kg–1) selective cytotoxic activity against cell line...
This research studied the formation of sodium polygalacturonate complexes with antimicrobial drug "Tetracycline". The was confirmed by IR, UV and NMR spectroscopy. It shown that were formed electrostatic attraction hydrogen bonding. demonstrated a high degree binding to polysaccharide matrix maximum content tetracycline (6.68 wt %). study activity obtained compounds against S. aureus, B. cereus, E. coli showed no decrease in effect compared source tetracycline. Thus, future towards new...
The formation of stable complexes pectin polysaccharides with the hypotensive drug “Nifedipine” was confirmed by IR and UV spectroscopy, their stoichiometry determined conditions production were optimized. Peculiarities thermal decomposition synthesized nifedipine studied TGA/DSC method. results obtained are a scientific basis for creation new water-soluble non-toxic dosage form nifedipine, which will significantly expand use in medicine.