A5102843530- Immune Response and Inflammation
- Nuclear Receptors and Signaling
- interferon and immune responses
- Peroxisome Proliferator-Activated Receptors
- Immunodeficiency and Autoimmune Disorders
- Diabetes Treatment and Management
- Genomics and Rare Diseases
Newcastle University
2022
Type I interferons (IFN-I) play a critical role in human antiviral immunity, as demonstrated by the exceptionally rare deleterious variants of IFNAR1 or IFNAR2. We investigated five children from Greenland, Canada, and Alaska presenting with viral diseases, including life-threatening COVID-19 influenza, addition to meningoencephalitis and/or hemophagocytic lymphohistiocytosis following live-attenuated vaccination. The affected individuals bore same homozygous IFNAR2 c.157T>C,...
Background: Statins lower low-density lipoprotein cholesterol (LDL-C) and reduce the risk of coronary artery disease (CAD). However, they also increase type 2 diabetes (T2D). Methods: We consider genetic variants in region HMGCR gene, which encodes target statins, their associations with downstream consequences statins. use various statistical methods to identify causal pathways influencing CAD T2D, investigate whether these are same or different for two diseases. Results: Colocalization...
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