A5091043328- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Pleural and Pulmonary Diseases
- Epigenetics and DNA Methylation
- Blood disorders and treatments
- Renal cell carcinoma treatment
- Cancer Diagnosis and Treatment
- Occupational and environmental lung diseases
- Fungal Infections and Studies
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Neutropenia and Cancer Infections
- Medical Imaging and Pathology Studies
- TGF-β signaling in diseases
- Hedgehog Signaling Pathway Studies
- Developmental Biology and Gene Regulation
- Cancer-related gene regulation
Breast Cancer Trials
2025
Calvary Mater Newcastle Hospital
2018-2020
Royal North Shore Hospital
2015
Garvan Institute of Medical Research
2009-2011
St Vincent's Hospital Sydney
2010-2011
The University of Sydney
2010
UNSW Sydney
2010
Cancer Institute of New South Wales
2010
St George Hospital
2010
Westmead Hospital
2010
Abstract β-catenin is involved in cell adhesion through catenin-cadherin complexes and as a transcriptional regulator the Wnt signaling pathway. Its deregulation important genesis of number human malignancies, particularly colorectal cancer. A range studies has been undertaken breast cancer, with contradictory associations reported among expression, clinicopathologic variables, disease outcome. We undertook an immunohistochemical study measuring levels subcellular localization 292 invasive...
Zardawi S J, I, McNeil C M, Millar E K A, McLeod D, Morey A L, Crea P, Murphy N C, Pinese Lopez‐Knowles E, Oakes R, Ormandy Qiu M Hamilton Spillane Soon Lee Sutherland R Musgrove & O’Toole (2010) Histopathology 56, 286–296 High Notch1 protein expression is an early event in breast cancer development and associated with the HER‐2 molecular subtype Aims: Activation of Notch signalling results hyperplasia tumorigenesis murine mammary epithelium. However, there little information regarding...
Localized malignant pleural mesothelioma (LMM) is a rare subset of mesothelioma. Its epidemiology, biology, natural history and optimal treatment are poorly understood. We report case LMM treated aggressively with complete surgical resection adjuvant radiotherapy, but subsequently complicated by local chest wall recurrence solitary metastasis to the kidney. This examined in context small number cases literature emphasize existence this disease entity, their unusual biological behaviour need...
Abstract Background Pegfilgrastim, a pegylated granulocyte colony‐stimulating‐factor (GCSF), reduces chemotherapy morbidity and mortality in early stage breast cancer. The optimal approach to individual patient selection for GCSF is unknown, particular whether secondary should be given after asymptomatic neutropenia, or only febrile neutropenia (FN). Aims To determine if preplanned nadir blood counts subsequent nadir‐neutropenia directed was effective reduce rates of FN associated with...
Introduction: Breast and renal carcinomas are common malignancies, with an increasing number of well-tolerated targeted therapies.Case Report: We describe a case concurrent, synchronous, metastatic breast where diagnosis was achieved after biopsy two incongruous sites.The patient has been successfully treated therapies, exemestane sunitinib, later anastrozole pazopanib, radiological improvement resolution symptoms.Conclusion: Literature review cases antecedent, synchronous metachronous...