A5090709221- Malaria Research and Control
- HIV Research and Treatment
- Drug Transport and Resistance Mechanisms
- Enzyme Production and Characterization
- Complement system in diseases
- Microbial Metabolites in Food Biotechnology
- Polysaccharides and Plant Cell Walls
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Biochemical and Structural Characterization
University of Oxford
2023
University of Birmingham
2016-2019
Abstract The symptoms of malaria occur during the blood stage infection, when parasites invade and replicate within human erythrocytes. PfPCRCR complex 1 , containing PfRH5 (refs. 2,3 ), PfCyRPA, PfRIPR, PfCSS PfPTRAMP, is essential for erythrocyte invasion by deadliest parasite, Plasmodium falciparum . Invasion can be prevented antibodies 3–6 or nanobodies against each these conserved proteins, making them leading blood-stage vaccine candidates. However, little known about how functions...
ABSTRACT Mycobacterium tuberculosis , the etiological agent of (TB), has a unique cell envelope which accounts for its unusual low permeability and contributes to resistance against common antibiotics. The main structural elements wall consist cross-linked network peptidoglycan (PG) in some muramic acid residues are covalently attached complex polysaccharide, arabinogalactan (AG), via α- l -rhamnopyranose–(1→3)-α- d -GlcNAc-(1→P) linker unit. While molecular genetics associated with PG AG...
The symptoms of malaria occur during the blood stage infection, when parasites invade and replicate within human erythrocytes. five-component PfPCRCR complex, containing PfRH5, PfCyRPA, PfRIPR, PfCSS PfPTRAMP, is essential for erythrocyte invasion by deadliest parasite, Plasmodium falciparum. Invasion can be prevented antibodies or nanobodies against each these five conserved proteins, making them leading vaccine candidates. However, little known about molecular mechanism which functions...