A5090802190- Genomics and Phylogenetic Studies
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
Max Planck Institute for Molecular Genetics
2020-2025
Abstract Segmental duplications (SDs) are long genomic that fixed in a genome. SDs play an important evolutionary role because entire genes can be duplicated along with regulatory sequences. The ancestral segmental of the human lineage gave rise to involved development brain and provided sites for further rearrangements. While some loci have been extensively studied, universal principles biological factors underlying spread remain unclear. Here we represent network, edges corresponding...
Abstract Background Segmental duplications (SDs) are long DNA sequences that repeated in a genome and have high sequence identity. In contrast to repetitive elements they often unique only sometimes multiple copies genome. There several well-studied mechanisms responsible for segmental duplications: non-allelic homologous recombination, non-homologous end joining replication slippage. Such play an important role evolution, however, we do not full understanding of the dynamic properties...
Abstract In the course of sample preparation for Next Generation Sequencing (NGS), DNA is fragmented by various methods. Fragmentation shows a persistent bias with regard to cleavage rates dinucleotides. With exception CpG dinucleotides previously described biases were consistent results in solution. Here we computed all including methylated and unmethylated using data Whole Genome datasets 1000 Genomes project. We found that rate significantly higher Using this information, developed...
A bstract Segmental duplications (SDs) are long genomic fixed in a genome. SDs play an important evolutionary role: entire genes together with regulatory sequences can be duplicated. Ancestral segmental gave rise to involved human brain development, as well provided sites for further rearrangements. Some duplicated loci were extensively studied, however, universal principles or biological factors of propagation not fully described yet. arranged into network where edges correspond real...