A5034760786- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Ocular Diseases and Behçet’s Syndrome
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders Research
- Systemic Sclerosis and Related Diseases
- Retinal and Optic Conditions
- Tryptophan and brain disorders
- Sarcoidosis and Beryllium Toxicity Research
- Liver Diseases and Immunity
- Salivary Gland Disorders and Functions
- Multiple Sclerosis Research Studies
- Adolescent and Pediatric Healthcare
- Monoclonal and Polyclonal Antibodies Research
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders
- Human Health and Disease
- Inflammasome and immune disorders
- Atherosclerosis and Cardiovascular Diseases
- Osteomyelitis and Bone Disorders Research
- Healthcare Systems and Public Health
- Bipolar Disorder and Treatment
- Pregnancy and Medication Impact
- Long-Term Effects of COVID-19
VA Nasonova Scientific Research Institute of Rheumatology
2015-2024
Ministry of Health of the Russian Federation
2018-2019
Helmholtz Moscow Research Institute of Eye Diseases
2019
Sechenov University
2018
Federal Medical Research Centre for Psychiatry and Narcology
2018
Pirogov Russian National Research Medical University
2018
Russian Academy of Sciences
1998-2015
Center for Rheumatology
2014
Institute of Rheumatology
2014
Institute for Rheumatic Diseases (Japan)
2013
Inflammation and coagulation are key basic mechanism of protection against all potentially pathogenic mechanical biological factors targeting human organism from inner outer environment. On the other hand, uncontrolled inflammation results in hypercoagulation, inhibition anticoagulation alteration mechanisms responsible for resolution inflammation, while production “procoagulant” mediators (thrombin, tissue factor others), activation platelets vascular endothelial cells maintains...
The negative impact of chronic disease on the psychological well-being and adaptation patients with rheumatoid arthritis (RA) remains a common problem despite advances in its comprehensive treatment rehabilitation. In this context, it is important to investigate factors that determine extent anxiety depression RA. Objective : analyze perception disease, mindfulness self-compassion as characteristics RA marked anxiety-depressive manifestations. Material methods . A total 180 (149 women 31...
The aim – to determine the clinical significance of hyperproduction antibodies NR2 subunit glutamate N-methyl-D-aspartate receptors (aNMDAR) in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Material methods . study included 66 reliable diagnoses SLE APS (SLE 24 patients; SLE+APS 18 patients, primary patients). Young women (35.5±10.2 years) prevailed (72.7%). All were examined according standards recommended by Association Rheumatologists Russia, also a...
Research objective - comparative analysis of incidence and structure anxiety-depressive spectrum disorders (ADD) in patients with various rheumatic diseases (RD).613 RD were enrolled the study: 180 a reliable diagnosis systemic lupus erythematosus (SLE), 128 rheumatoid arthritis (RA), 110 sclerosis (SSc), 115 Behcet's disease (BD), 80 primary Sjögren's syndrome (pSS). Female prevailed all groups (95% pSS, 88,2% SSc, 87,2% RA, 85,5% SLE) except BD (70% male). The mean age was 42.3±1.54 years...
The review summarizes current idea on the key role of interleukin 6 (IL-6) in pathogenesis rheumatic diseases (RDs) and depressive disorders. It considers detail mechanisms by which IL6 induces clinical laboratory manifestations RDs depression; influence precipitating predisposing stress factors, including childhood mental traumas, increase risk depression, IL-6 production. Particular attention is paid to consideration prospects for using inhibitors therapy depression.
The aim of this work is to clarify the association between clinical and psychopathological features mental disorders (MD) immunological antiphospholipid syndrome (APS). Material methods . study included 107 patients (34 (31.8%) men 73 (68.2%) women) aged 18 69 years (40.6±10.4 (M±SD)), 54 (50.5%) – with primary APS (PAPS), established according international criteria 2006 53 (49.5%) reliable diagnosis systemic lupus erythematosus (SLE), European Alliance Associations for...
Background . Interleukin (IL) 6 plays an important role in the pathogenesis of comorbid rheumatoid arthritis (RA) depression, and IL-6 inhibitors (i) used to treat RA patients may have antidepressant effect. Objective – evaluate effectiveness Russian iIL-6 olokizumab (OKZ) reducing symptoms depression with moderate/high activity. Material methods. To date, 49 been included, which 43 (87.7%) are women, average age 47.8±12.8 years; a predominant high activity according DAS28 (CRP) indices...
The start of the new millennium is marked by a substantial progress in development rheumatology: pathogenesis many rheumatic diseases (RDs) was more deeply studied; their diagnostic criteria validated; disease activity indices worked out; concepts remission and exacerbation introduced; much attention has been given to investigations quality life patients. possibility pharmacotherapy for immunoinflammatory RDs extended advent biological agents (BA). treatment strategy also changed....
Objective: to reveal irreversible organ damages and establish factors that influence their development in a RENAISSANCE cohort of patients with systemic lupus erythematosus (SLE) admitted the clinic V.A. Nasonova Research Institute Rheumatology period 2012 2014. Subjects methods. The investigation enrolled 231 young (mean age, 34.91±11.10 years) (209 women 22 men) mean SLE duration 107.65±97.36 months. On admission patients, investigators collected history data (disease duration, number...
activity and severity of the disease, approaches to therapy.
The paper considers the prevalence, pattern, and clinical features of mental disorders (MDs) that are characteristic of patients with immune-mediated inflammatory rheumatic diseases (RDs). It discusses in detail risk factors for MDs, their pathogenesis, association activity, major symptoms RD. Particular emphasis is placed on diagnosis treatment MDs patients RDs primary health care facilities at rheumatology hospitals.
The article is devoted to the new guidelines of EULAR on management patients with Behcet's disease/syndrome (BD), which include 5 principles and 10 specific recommendations for treatment various organ lesions. methodology their creation, as well unresolved issues BD, are planned be investigated in future, considered.
The paper discusses the common comorbidity of immune inflammatory rheumatic diseases (RD) and depression. It considers causes mechanisms, which are to these diseases, namely, provocative role chronic psychosocial stress; neuroendocrine dysregulations an response, give rise hyperproduction proinflammatory cytokines determining magnitude major clinical syndromes RD depression — pain, fatigue, sleep disorders, functional insufficiency. impact on patient treatment adherence efficiency course...
Background. Olokizumab is a new interleukin-6 (IL-6) inhibitor that has demonstrated good efficacy and safety for the treatment of adult patients with moderate to high-grade activity rheumatoid arthritis in combination methotrexate insufficient monotherapy. Aim study was evaluate effectiveness olokizumab relation patient’s reported outcomes (PROs) based on results obtained CREDO 1 phase III study. Material methods. The included 428 who were randomized into 3 groups: group – received 64 mg...
Aim. To assess the influence of anxiety and depressive disorders on joint destruction in patients with rheumatoid arthritis (RA). Materials methods. 128 RA-patients were included, 87% women a mean age 47.411.3 years median RA duration 96 [48; 228] months. At inclusion most had moderate (n=56, 43.7%) severe (n=48, 37.5%) disease activity according to DAS28. Joint was classified as maximal radiographic stage III, IV and/or osteonecrosis) minimal I, II no osteonecrosis. Pain intensity measured...
Система комплексной поддержки и сопровождения научного журнала Elpub позволяет запустить двуязычный сайт со встроенной системой электронной редакции в соответствии с лучшими издательскими практиками, а так же предусматривает техническую методическую поддержку стороны специалистов НЭИКОН.
The article presents the data of international registries and cohort studies systemic lupus erythematosus (SLE). It justifies purpose objectives registry SLE patients, a Eurasian (RENAISSANCE), which was launched in 2012 amalgamated leading rheumatology centers Russian Federation (V.A. Nasonova Research Institute Rheumatology; Department Rheumatology, Pacific State Medical University), Kazakhstan (Department S.D. Asfendiyarov Kazakh National Kyrgyzstan (Academician M. Mirrakhimov Center...
The response rate to therapy for rheumatoid arthritis (RA) rarely exceeds 60%. Mental disorders (MDs) of the anxiety-depressive spectrum (ADS) and cognitive impairment (CI) substantially affect evaluation efficiency RA therapy. Adequate psychopharmacotherapy is one possible approaches optimizing treatment RA. factors influencing with standard disease-modifying antirheumatic drugs (DMARDs) biological agents (BAs) in combination adequate have not been previously identified. Objective:...
The aim of the study was to analyze factors affecting chronic pain in patients with rheumatoid arthritis (RA).128 reliable diagnosis RA [111 (86.7%) women and 17 (13.3%) men] were examined. mean age 47.4±11.3 years, median duration disease 96 [48; 228] months. When included most patients, activity DAS28 moderate (n=56; 43.7%) or high (n=48; 37.5%). BPI (Brief Pain Inventory) scale used determine severity its impact on various aspects life. anxiety - depressive spectrum disorders (ADDs)...
<h3>Background</h3> Chronic depression is the most frequent psychiatric disorder in rheumatoid arthritis (RA) patients. It9s considered that both depressive disorders and RA are stress-related have a common proinflammatory pathogenesis. Moreover, decreases adherence to treatment worsen prognosis. That why untreated may deteriorate joints destruction <h3>Objectives</h3> To determine factors associated with patients by linear regression analysis influence of chronic on destruction....
Mental disorders (MDs) of the anxiety-depressive spectrum (ADS) and cognitive impairment (CI) are characteristic majority patients with rheumatoid arthritis (RA); however, effects disease-modifying antirheumatic drugs (DMARDs), biological agents (BAs), their combinations psychopharmacological (PPDs) on these abnormalities have been insufficiently studied. Objective : to investigate trends in incidence MDs RA receiving different treatment regimens. Subjects methods . The investigation...
Система комплексной поддержки и сопровождения научного журнала Elpub позволяет запустить двуязычный сайт со встроенной системой электронной редакции в соответствии с лучшими издательскими практиками, а так же предусматривает техническую методическую поддержку стороны специалистов НЭИКОН.