The aim – to determine the clinical significance of hyperproduction antibodies NR2 subunit glutamate N-methyl-D-aspartate receptors (aNMDAR) in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Material methods . study included 66 reliable diagnoses SLE APS (SLE 24 patients; SLE+APS 18 patients, primary patients). Young women (35.5±10.2 years) prevailed (72.7%). All were examined according standards recommended by Association Rheumatologists Russia, also a...

Research objective - comparative analysis of incidence and structure anxiety-depressive spectrum disorders (ADD) in patients with various rheumatic diseases (RD).613 RD were enrolled the study: 180 a reliable diagnosis systemic lupus erythematosus (SLE), 128 rheumatoid arthritis (RA), 110 sclerosis (SSc), 115 Behcet's disease (BD), 80 primary Sjögren's syndrome (pSS). Female prevailed all groups (95% pSS, 88,2% SSc, 87,2% RA, 85,5% SLE) except BD (70% male). The mean age was 42.3±1.54 years...

The review summarizes current idea on the key role of interleukin 6 (IL-6) in pathogenesis rheumatic diseases (RDs) and depressive disorders. It considers detail mechanisms by which IL6 induces clinical laboratory manifestations RDs depression; influence precipitating predisposing stress factors, including childhood mental traumas, increase risk depression, IL-6 production. Particular attention is paid to consideration prospects for using inhibitors therapy depression.

The aim of this work is to clarify the association between clinical and psychopathological features mental disorders (MD) immunological antiphospholipid syndrome (APS). Material methods . study included 107 patients (34 (31.8%) men 73 (68.2%) women) aged 18 69 years (40.6±10.4 (M±SD)), 54 (50.5%) – with primary APS (PAPS), established according international criteria 2006 53 (49.5%) reliable diagnosis systemic lupus erythematosus (SLE), European Alliance Associations for...

Background . Interleukin (IL) 6 plays an important role in the pathogenesis of comorbid rheumatoid arthritis (RA) depression, and IL-6 inhibitors (i) used to treat RA patients may have antidepressant effect. Objective – evaluate effectiveness Russian iIL-6 olokizumab (OKZ) reducing symptoms depression with moderate/high activity. Material methods. To date, 49 been included, which 43 (87.7%) are women, average age 47.8±12.8 years; a predominant high activity according DAS28 (CRP) indices...

The paper considers the prevalence, pattern, and clinical features of mental disorders (MDs) that are characteristic of patients with immune-mediated inflammatory rheumatic diseases (RDs). It discusses in detail risk factors for MDs, their pathogenesis, association activity, major symptoms RD. Particular emphasis is placed on diagnosis treatment MDs patients RDs primary health care facilities at rheumatology hospitals.

The paper discusses the common comorbidity of immune inflammatory rheumatic diseases (RD) and depression. It considers causes mechanisms, which are to these diseases, namely, provocative role chronic psychosocial stress; neuroendocrine dysregulations an response, give rise hyperproduction proinflammatory cytokines determining magnitude major clinical syndromes RD depression — pain, fatigue, sleep disorders, functional insufficiency. impact on patient treatment adherence efficiency course...

Aim. To assess the influence of anxiety and depressive disorders on joint destruction in patients with rheumatoid arthritis (RA). Materials methods. 128 RA-patients were included, 87% women a mean age 47.411.3 years median RA duration 96 [48; 228] months. At inclusion most had moderate (n=56, 43.7%) severe (n=48, 37.5%) disease activity according to DAS28. Joint was classified as maximal radiographic stage III, IV and/or osteonecrosis) minimal I, II no osteonecrosis. Pain intensity measured...

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The response rate to therapy for rheumatoid arthritis (RA) rarely exceeds 60%. Mental disorders (MDs) of the anxiety-depressive spectrum (ADS) and cognitive impairment (CI) substantially affect evaluation efficiency RA therapy. Adequate psychopharmacotherapy is one possible approaches optimizing treatment RA. factors influencing with standard disease-modifying antirheumatic drugs (DMARDs) biological agents (BAs) in combination adequate have not been previously identified. Objective:...

The aim of the study was to analyze factors affecting chronic pain in patients with rheumatoid arthritis (RA).128 reliable diagnosis RA [111 (86.7%) women and 17 (13.3%) men] were examined. mean age 47.4±11.3 years, median duration disease 96 [48; 228] months. When included most patients, activity DAS28 moderate (n=56; 43.7%) or high (n=48; 37.5%). BPI (Brief Pain Inventory) scale used determine severity its impact on various aspects life. anxiety - depressive spectrum disorders (ADDs)...

<h3>Background</h3> Chronic depression is the most frequent psychiatric disorder in rheumatoid arthritis (RA) patients. It9s considered that both depressive disorders and RA are stress-related have a common proinflammatory pathogenesis. Moreover, decreases adherence to treatment worsen prognosis. That why untreated may deteriorate joints destruction <h3>Objectives</h3> To determine factors associated with patients by linear regression analysis influence of chronic on destruction....

Mental disorders (MDs) of the anxiety-depressive spectrum (ADS) and cognitive impairment (CI) are characteristic majority patients with rheumatoid arthritis (RA); however, effects disease-modifying antirheumatic drugs (DMARDs), biological agents (BAs), their combinations psychopharmacological (PPDs) on these abnormalities have been insufficiently studied. Objective : to investigate trends in incidence MDs RA receiving different treatment regimens. Subjects methods . The investigation...

Aim. To clarify the relationship between clinical and psychopathological features of mental disorders, laboratory manifestations activity nature course systemic lupus erythematosus (SLE). Materials methods. The study included 119 patients 98 (82.4%) women, mean age 36.512.4 years (MSD) with a reliable diagnosis SLE (EULAR/ACR 2019 criteria), 51 (29.5%) them secondary antiphospholipid syndrome APS (International criteria 2006). Results. Among high frequency anxiety-depressive spectrum...

To perform a psychopathological and clinical/psychological analysis of anxiety-depressive spectrum disorders (ADSD) in inflammatory otorhinolaryngological disease - larynx granuloma.We examined 30 patients, aged 33-65 years, including 13 patients with post-surgical recurrence granuloma 17 diagnosed for the first time granuloma.The relationship between ADSD, predominantly chronic type was shown. Prolonged psychotraumatic factors play significant role development ADSD. A anxiety ADSD structure...

To study the prevalence of cognitive disorders (CD) and clinical/pathogenetic correlations CD in patients with Behçet's Disease (BD).One hundred six BD were enrolled study. The majority natives North Caucasus (51.9%). Mean age was 33.3±0.98 years, mean illness duration 148.5±10.4 months. All met criteria International Study Group for (1990) classification. disease activity assessed by scoring system BDCAF. A diagnosis a mental disorder (MD) established psychiatrist accordance ICD-10 using...

To analyze of the prevalence stressful factors and mental disorders (MDs), as well their clinical psychopathological psychological characteristics to improve comprehensive diagnosis treatment systemic scleroderma (SSD).Examinations were performed in 110 patients (predominantly women (n=97 (88.2%); mean age, 49.9±2.47 years) with a documented SSD (its duration, 7.25±0.42 years). 62 (56.4%) had limited SSD, 36 (32.7%) diffuse 12 (10.9%) overlap syndrome. The disease was rapidly slowly...

О р и г н а л ь ы е с д о в я 1 ФГБНУ «Научно-исследовательский институт ревматологии им.В.А.Насоновой», Москва, Россия; 2 Московский научно-исследовательский психиатрии -филиал ФГБУ «Национальный медицинский исследовательский центр наркологии им.В.П.Сербского» Минздрава России; 3 ФГАОУ ВО «Первый государственный университет им.И.М.

<h3>Background</h3> Psychiatric disorders occur in rheumatoid arthritis (RA) patients very often. It is considered that major depressive disorder (MDD) RA stress-related and associated with disease activity chronic pain. <h3>Objectives</h3> to determine the factors MDD pts by linear regression analysis. <h3>Methods</h3> 125 were enrolled this study. 86% women a mean age of 47.4±11.3 (M±m). The was assessed DAS28 score. 52% had high (DAS28&gt;5,1). 67% taking prednisone dose 5±2.7 mg/day 80%...

Aim – to assess baseline rates and five-years outcomes of mild cognitive impairments (MCI) in patients with rheumatoid arthritis (RA) comorbid anxiety depressive disorders (ADD) receiving conventional synthetic diseasemodifying antirheumatic drugs (csDMARDs) alone or combination biologic DMARDs (bDMARDs) and/or adequate psychopharmacotherapy (PPT). To factors associated MCI after five years. Materials methods . 128 RA were enrolled, ADD diagnosed 123 (96.1%) by a licensed psychiatrist....

The aim – to determine the frequency and characteristics of anxiety-depressive spectrum disorders (ADSD) in patients with obstetric antiphospholipid syndrome (APS). Material methods. study is prospective-retrospective. Data on pathology was obtained from medical documents conversation a patient. Stress factors were assessed upon inclusion study. Diagnosis ADSD carried out by psychiatrist, according ICD-10. included 61 women APS, established international criteria 2006, who had history...