A5049511464- Photosynthetic Processes and Mechanisms
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Plant Molecular Biology Research
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Legume Nitrogen Fixing Symbiosis
- Plant Parasitism and Resistance
- Plant Pathogenic Bacteria Studies
- Nerve injury and regeneration
- Mycorrhizal Fungi and Plant Interactions
- Pluripotent Stem Cells Research
- Plant-Microbe Interactions and Immunity
- Plant Virus Research Studies
University of Cambridge
2017-2025
Ithaca College
2009
Cornell University
2009
Institute of Groundwater Ecology
2004
Ludwig-Maximilians-Universität München
2004
Summary Arbuscular mycorrhizal (AM) symbiosis is a widespread mutualism formed between vascular plants and fungi of the Glomeromycota. In this endosymbiosis, fungal hyphae enter roots, growing through epidermal cells to cortex where they establish differentiated called arbuscules in cortical cells. Reprogramming plant occurs enable intracellular growth symbiont; however, genes underlying process are largely unknown. Here, use RNAi, we demonstrate that expression Medicago truncatula gene...
Significance The majority of eukaryotes reproduce sexually, creating genetic variation within populations. Sexual reproduction requires gamete production via meiotic cell division. During meiosis, homologous chromosomes pair and undergo exchange, called crossover. Crossover is vital for crop breeding remains a major tool to combine useful traits. Despite the importance crossovers breeding, their levels are typically low, with one two forming per chromosome, irrespective physical chromosome...
During meiosis, interhomolog recombination produces crossovers and noncrossovers to create genetic diversity. Meiotic frequency varies at multiple scales, with high subtelomeric suppressed centromeric typical in many eukaryotes. recombination, sister chromatids are tethered as loops a polymerized chromosome axis, which, plants, includes the ASY1 HORMA domain protein REC8–cohesin complexes. Using chromatin immunoprecipitation, we show an ascending telomere-to-centromere gradient of...
Meiosis recombines genetic variation and influences eukaryote genome evolution. During meiosis, DNA double-strand breaks (DSBs) enter interhomolog repair to yield crossovers noncrossovers. DSB occurs as replicated sister chromatids are connected a polymerized axis. Cohesin rings containing the REC8 kleisin subunit bind anchor chromosomes Here, we report genomic landscape of using chromatin immunoprecipitation sequencing (ChIP-seq) in Arabidopsis (Arabidopsis thaliana). associates with...
Background: Centromeres mediate chromosome segregation during cell division. In plants, centromeres are loaded with CENH3-variant nucleosomes, which direct kinetochore formation and spindle microtubule interaction. Plant frequently composed of megabase-scale satellite repeat arrays, or retrotransposon nests. monocentric genomes, such as Arabidopsis thaliana, extended regions pericentromeric heterochromatin surround the CENH3-occupied arrays. A zone suppressed meiotic crossover recombination...
Abstract During meiosis chromosomes undergo DNA double-strand breaks (DSBs) that can be repaired using a homolog to produce crossovers, which creates genetic diversity. Meiotic recombination occurs coincident with pairing and polymerization of the meiotic axis synaptonemal complex (SC). REC8-cohesin is required connect organize polymerization. However, control REC8 loading along chromosomes, in relation chromatin, transcription recombination, not yet fully understood. Therefore, we performed...
Abstract During meiosis homologous chromosomes undergo reciprocal crossovers, which generate genetic diversity and underpin classical crop improvement. Meiotic recombination initiates from DNA double strand breaks, are processed into single-stranded that can invade a chromosome. The resulting joint molecules ultimately be resolved as crossovers. In Arabidopsis, competing pathways balance the repair of ∼100–200 meiotic DSBs ∼10 crossovers per meiosis, with excess repaired non-crossovers....