A5024816667- Plant biochemistry and biosynthesis
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Alkaloids: synthesis and pharmacology
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Plant and Fungal Species Descriptions
- RNA Research and Splicing
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Traditional and Medicinal Uses of Annonaceae
- Cancer, Lipids, and Metabolism
- Ginseng Biological Effects and Applications
- Genomics and Phylogenetic Studies
- Polyomavirus and related diseases
- Echinoderm biology and ecology
- Research in Cotton Cultivation
- Kruppel-like factors research
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Heat shock proteins research
- Autophagy in Disease and Therapy
- Marine Sponges and Natural Products
- Multiple and Secondary Primary Cancers
Guangxi Medical University
2016-2024
Stanford University
1995
RsmA is an RNA-binding protein functioning as a global post-transcriptional regulator of various cellular processes in bacteria and has been demonstrated to be important virulence many animal bacterial pathogens. However, its function other phytopathogenic unclear, except for the Erwinia carotovora RsmA, which acts negative regulator. In this work, we investigated rsmA-like gene, named rsmA(Xcc), phytopathogen Xanthomonas campestris pv. campestris. Deletion rsmA(Xcc) resulted complete loss...
Abstract Activation of T cells leading to graft-vs-host disease (GVHD) requires two signaling events: the Ag-specific signal generated through engagement TCR/CD3 complex with antigenic peptide fragments presented by MHC molecules on APCs and second provided additional costimulatory ligands. have preferential requirements depending their state activation-induced maturation. In present study, we investigated role receptor-ligand pair VLA-4 (alpha 4 beta 1) VCAM-1 in allogeneic cell responses...
Objective: This study aimed at investigating the specific roles of laminarin from seaweed (Laminaria japonica) in hepatocellular carcinoma (HCC) and its potential mechanisms related to senescence marker protein-30 (SMP-30). Materials Methods: Human HCC cell lines, including Bel-7404 HepG2, were incubated with different concentrations (0, 5, 15, 25, 35, 45 mg/mL). The viability apoptosis rates detected by WST-8 proliferation assay flow cytometry, respectively. Hepa 1–6 tumor-bearing mice...
While DNA barcoding is an important technology for the authentication of botanical origins Chinese medicines, suitable markers genus Uncaria have not been reported yet. This study aims to determine (Gouteng).Genomic was extracted from freshly dried leaves plants by a Bioteke's Plant Genomic Extraction Kit. Five candidate barcode sites (ITS2, rbcL, psbA-trnH, ITS, and matK) were amplified PCR with established primers. The purified products bidirectionally sequenced appropriate amplification...
G. pentaphyllum ( Gynostemma ), a creeping herbaceous perennial with many important medicinal properties, is widely distributed in Asia. Gypenosides (triterpenoid saponins), the main effective components of , are well studied. FPS (farnesyl pyrophosphate synthase), SS (squalene and SE epoxidase) enzymes involved synthesis triterpenoid saponins. Considering functions it necessary to investigate transcriptomic information facilitate future studies transcriptional regulation. After sequencing...
Farnesyl pyrophosphate synthase (FPS) belongs to the short-chain prenyltransferase family, and it performs a conserved essential role in terpenoid biosynthesis pathway. However, its classification, evolutionary history, forces driving evolution of FPS genes plants remain poorly understood. Phylogeny positive selection analysis was used identify that led functional divergence plants, recombinant detection undertaken using Genetic Algorithm for Recombination Detection (GARD) method. The...
Triterpenoid saponins are secondary metabolites synthesized through isoprenoid pathways in plants. Cucurbitaceae represent an important plant family which many species contain cucurbitacins as and triterpenoid pathways. Squalene synthase (SQS) is required for the biosynthesis of isoprenoids, but forces driving evolution SQS remain undetermined. In this study, 10 cDNA sequences cloned from 49 downloaded GenBank UniProt databases were analyzed a phylogenetic framework to identify evolutionary...
Background: Hepatocellular carcinoma (HCC) presents a common malignant tumor worldwide.Although kinectin 1 (KTN1) is the most frequently identified antigen in HCC tissues, detailed roles of KTN1 remain unknown.This study seeks to clarify expression status and clinical value explore complicated biological functions its underlying mechanisms.Methods: In-house reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used detect tissues.External gene microarrays RNA-sequencing...
Heat-shock protein (HSP) GP96 is a well-known adjuvant in immunotherapy. It belongs to the HSP90 family. Our previous study demonstrated that DC pulsed with recombinant senescence marker 30 (SMP30) could induce cytotoxic T lymphocytes (CTLs) against liver cancer cells vitro. In this study, SMP30 and were subcloned into lentiviruses transfected DCs from healthy donors. We included six groups: GP96-SMP30 group, empty vector control hepatoma extracted group. used ELISA detect cytokines flow...
The in vitro and vivo effects of cryopreservation on the cytotoxic activity murine lymphokine‐activated killer (LAK) cells were studied. LAK generated by incubation spleen lymphocytes BALB/c mice for 3 days with recombinant interleukin‐2 (rIL‐2) subsequent cryopreservation. Cytotoxicity was determined a 51Cr release assay. After thawing, reduced (40.4% at an effector:target cell ratio 40:1 as compared to 68.5% before freezing) could be restored precryopreserved levels reincubation rIL‐2 2...
BACKGROUND Cell division cyclin 25C (CDC25C ) is a protein that plays critical role in the cell cycle, specifically transition from G2 phase to M phase. Recent research has shown CDC25C could be potential therapeutic target for cancers, particularly hepatocellular carcinoma (HCC). However, specific regulatory mechanisms underlying of HCC tumorigenesis and development remain incompletely understood. AIM To explore impact on proliferation apoptosis, as well its development. METHODS Hepa1-6 B16...
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Abstract Background. The importance of prostaglandin F2 receptor inhibitors (PTGFRN) in the progression a variety malignant tumors has been recognized recent years. So far, no role PTGFRN hepatocellular carcinoma (HCC) reported. In this study, we focused on possible mechanisms HCC based Cancer Genome Atlas (TCGA) data. Methods. mRNA gene expression data were downloaded from TCGA database to analyze level HCC. According human protein atlas database, difference between and adjacent tissues was...