A5075003579- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Lysosomal Storage Disorders Research
- Analytical chemistry methods development
- Occupational exposure and asthma
- Autophagy in Disease and Therapy
- Protein purification and stability
- Galectins and Cancer Biology
- Endoplasmic Reticulum Stress and Disease
University at Buffalo, State University of New York
2020-2022
Procter & Gamble (United States)
1988
African trypanosomes, the protozoan agent of human trypanosomaisis, avoid host immune system by switching expression variant surface glycoprotein (VSG). VSG is a long-lived protein that has long been thought to be turned over hydrolysis its glycolipid membrane anchor.
Abstract A new method is presented that utilizes p‐nitroanilide substrates to quantify proteolytic activity of detergent enzymes. The contrasted the dimethylcasein currently in use by industries, and advantages its potential for monitoring enzyme dust factories are discussed.
African trypanosomes evade the immune system of mammalian host by antigenic variation predominant glycosylphosphatidylinositol (GPI)-anchored surface protein, variant glycoprotein (VSG). VSG is a very stable protein that turned over from cell with long half-life (~26 h), allowing newly synthesized to populate surface. We have recently demonstrated turnover under normal growth mediated combination GPI hydrolysis and direct shedding intact anchors. synthesis tightly regulated in dividing...