A5034790533- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Additive Manufacturing and 3D Printing Technologies
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Nanotechnology research and applications
The University of Melbourne
2009-2015
Universidade de Vigo
2009
Understanding the interactions between drug carriers and cells is of importance to enhance delivery therapeutics. The release therapeutics into different intracellular environments, such as lysosomes or cell cytoplasm, will impact their pharmacological activity. Herein, we investigate fate layer-by-layer (LbL)-assembled, submicrometer-sized polymer hydrogel capsules in a human colon cancer derived line, LIM1899. cellular uptake disulfide-stabilized poly(methacrylic acid) (PMASH) by...
Studies of spherical nanoengineered drug delivery systems have suggested that particle size and mechanical properties are key determinants in vivo behavior; however, for more complex structures, detailed analysis correlations between vitro characterization disposition is lacking. Anisotropic materials particular bear unknowns terms tolerances clearance the impact shape rigidity. Herein, we employed cylindrical polymer brushes (CPBs) to answer questions related size, length rigidity on...
Engineered particles adsorb biomolecules (e.g., proteins) when introduced in a biological medium to form layer called "corona". Coronas, particular the protein corona, play an important role determining surface properties of and their targeting abilities. This study examines influence coronas on ability layer-by-layer (LbL)-assembled polymer capsules core–shell functionalized with monoclonal antibodies. Upon exposure humanized A33 antibody (huA33 mAb)-functionalized poly(methacrylic acid)...
We report the assembly of low-fouling polymer capsules with engineered deconstruction properties by using a combination layer-by-layer (LbL) and click chemistry. Preformed, hydrogen-bonded multilayers alkyne-functionalized poly(N-vinyl pyrrolidone) (PVPON(Alk)) poly(methacrylic acid) (PMA) assembled at pH 4 on silica particles were cross-linked bisazide linker (containing disulfide link) through alkyne-azide Following dissolution template particles, altering solution to 7.2 disrupt hydrogen...
We report a versatile approach for controlling the intracellular degradation of polymer capsules by tailoring degree cross-linking in capsules. Poly(2-diisopropylaminoethyl methacrylate) were assembled layer-by-layer technique and covalently stabilized with redox-responsive bisazide cross-linker using click chemistry. The cross-linking, determined radiation scintillation counting, was tuned from 65% to 98% adjusting amount used stabilize films. Transmission electron microscopy fluorescence...