A5064198225- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Birth, Development, and Health
- Dialysis and Renal Disease Management
- Sodium Intake and Health
- Nutritional Studies and Diet
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Renal and Vascular Pathologies
- Extracellular vesicles in disease
- Renal Diseases and Glomerulopathies
- Renal function and acid-base balance
- Diabetes Treatment and Management
- Muscle and Compartmental Disorders
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Organ Donation and Transplantation
- Cell death mechanisms and regulation
- Parathyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Thermoregulation and physiological responses
- PARP inhibition in cancer therapy
Rabin Medical Center
2015-2025
Tel Aviv University
2006-2025
Rockefeller University
2020-2024
Hypertension Institute
2022
University of California, Irvine
2021
University of California, Irvine Medical Center
2016
Selecting the optimal first-line therapy for type 2 diabetes is essential achieving glycemic control and providing cardio-renal protection, though combined benefits of metformin with SGLT2 inhibitors, remain uncertain. This retrospective cohort study analyzed data from Clalit Health Services (2016–2021), to compare outcome in adults treated inhibitors alone versus combination metformin. Propensity score matching was applied balance baseline characteristics between groups. Primary outcomes...
Abstract Objective To investigate the impact of Sodium-glucose cotransporter 2 (SGLT2) inhibitors on incidence, complications, and therapeutic demands anemia in patients with diabetes utilizing real-world data, compared to treatment dipeptidyl peptidase 4 (DPP4) inhibitors. Patients Methods In this retrospective cohort study, dataset was sourced from data repositories Clalit Health Services. Since January 1, 2016 through December 31, 2021 we identified type who received SGLT2 them a matched...
The dietary approach to stop hypertension (DASH) diet combines the antihypertensive effect of a low sodium and high potassium diet. In particular, component acts as switch in distal convoluted tubule reduce reabsorption, similar diuretic but without side effects. Previous trials understand mechanism DASH were based on animal models did not characterize changes human ion channel protein abundance. More recently, cargo urinary extracellular vesicles (uEVs) has been shown mirror tissue content...
ABSTRACT Background hydrochlorothiazide (HCTZ) diuretics were correlated with an increased risk of non-melanoma skin cancer (NMSC) and melanoma in the general population. Information is a scarce regarding this effect kidney transplant recipients who are at malignancies under immunosuppression. Methods Single-center retrospective analysis adult between 1 January 2010 31 December 2015. The primary outcome study was first diagnosis that removed pathologically analyzed. Exposure to thiazides...
Introduction: The correlation between hypercholesterolemia and cardiovascular disease in kidney transplant recipients (KTRs) remains uncertain. We sought to characterize the association abnormal cholesterol profiles morbidity mortality this unique population. Methods: This retrospective cohort study was conducted at a single center included all adult KTR, transplanted January 2005 April 2014. primary outcome major adverse events (MACE) while secondary composite of MACE all-cause mortality....
Bariatric surgery (BS) is the optimal approach for sustained weight loss and may alter donation candidacy in potential donors with obesity. We evaluated long-term effects of nephrectomy after BS on metabolic profile, including body mass index, serum lipids diabetes, kidney function donors.This was a single-center retrospective study. Live who underwent before were matched age, gender, index patients alone alone. Estimated glomerular filtration rate (eGFR) calculated according to Chronic...
Chronic kidney disease (CKD) is a risk factor for severe coronavirus 2019 (COVID-19). We aimed to evaluate the real-life effectiveness of BNT162b2 messenger RNA vaccine range outcomes in patients with CKD compared matched controls. Data from Israel's largest healthcare organization were retrospectively used. Vaccinated [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2] and maintenance dialysis vaccinated controls without (eGFR ≥60 m2) according demographic clinical...
Accumulating data indicate that sub-therapeutic levels of tacrolimus are associated with long-term kidney graft loss. However, elevated doses increase the risk infection and drug toxicity, which also threaten patient longevity. We sought to determine minimal level required maintain survival.We conducted a single-center historical cohort study. The first-year post-transplant exposure time was calculated for each five trough intervals. This measure adjusted below given interval level, allowing...
Adolescent obesity, a risk factor for cardiorenal morbidity in adulthood, has reached epidemic proportions. Obesity-related glomerulopathy (ORG) an early reversible stage of hyperfiltration. Age-appropriate formulae eGFR, which are standardized to ideal body surface area (BSA) and provide assessment kidney function ml/min/1.73 m2, may underestimate prevalence ORG. We investigated whether adjusting eGFR actual BSA more readily identifies ORG.We studied cohort 22,417 young individuals, aged...
BACKGROUND Kidney transplant recipients have higher life expectancy but may require subsequent transplantations, raising ethical concerns regarding organ allocation. We assessed the safety of multiple kidney transplants through long-term follow-up. MATERIAL AND METHODS A retrospective cohort study was conducted at a single center, categorizing patients based on number transplantations received. The primary outcome composite death-censored graft failure and overall mortality. secondary...
Abstract Background and Aims Kidney transplanted recipients are at increased risk of infections, including BK virus, for which there is no specific treatment. Current prevention strategies include surveillance stratification. We sought to estimate the contribution non-identical but compatible (mismatched) ABO blood types BKV viremia. Method A retrospective single-center study was conducted in kidney transplant between 1/1/2011 1/12/2021. The primary outcome viremia (&gt;10,000 copies per...
ABSTRACT Background Tacrolimus blood level variability is associated with reduced graft survival among kidney transplant recipients. To date, no practical approach for reducing has been validated. We defined specific tacrolimus patterns correlated and evaluated their independent association survival. Methods In this single‐center retrospective study, we predefined 12 that exhibited correlation high variability. Subsequently, utilized a multivariate Cox proportional hazard model, in...
Background: Microalbuminuria is a well-characterized marker of kidney malfunction, both in diabetic and non-diabetic populations, used as prognostic for cardiovascular morbidity mortality. A few studies implied that it has the same value transplanted patients, but information relies on spot or dipstick urine protein evaluations, rather than gold standard timed collection. Methods: We revisited cohort 286 several years after completing meticulously collection assessed prevalence major adverse...
Dietary approach to stop hypertension (DASH) diet reduces blood pressure (BP) as effectively one antihypertensive drug, yet its mechanism of action was never fully characterized.We designed a translational inpatient trial elucidate the biological pathway leading from nutritional change, through hormonal response, reversal urine electrolytes ratio, BP reduction.A single-center open-label interventional trial. Volunteers were admitted for 14 days, transitioning an American-style DASH diet....
Low-income, minority seniors face high rates of hypertension that increase cardiovascular risk. Senior centers offer services, including congregate meals, can be a valuable platform to reach older adults in underserved communities. We implemented two evidence-based interventions not previously tested this setting: DASH-aligned meals and Self-Measured Blood Pressure (SMBP), lower blood pressure (BP) at senior serving low-income, racially diverse The study enrolled meal program participants,...
Abstract Background The prevailing assumption is that following kidney transplantation the pattern of function decline consistent. Nevertheless, numerous factors leading to graft loss may emerge, altering trajectory function. In this study, we aim assess alterations in estimated glomerular filtration rate (eGFR) over an extended period follow‐up and examine its correlation with survival. Methods We calculated eGFR using all creatinine values available from 1‐year post end follow‐up. For...
OBJECTIVES/GOALS: 1. analyze urinary protein exosome content pattern before and during DASH diet. 2. characterize urine electrolyte changes associated with in profiles, hormonal before/after 3. the association of these to DASH-related BP response. METHODS/STUDY POPULATION: In this proof concept study, hypertension stage 1 volunteers will receive a based menu 14 consecutive days elective admission RU research hospital. Participants complete food frequency questionnaire (VioScreen)...