A5017312887- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Effects and risks of endocrine disrupting chemicals
- Pluripotent Stem Cells Research
- Heavy Metal Exposure and Toxicity
- Health, Environment, Cognitive Aging
- Microstructure and mechanical properties
- Aluminum Alloy Microstructure Properties
- RNA Interference and Gene Delivery
- Carbon and Quantum Dots Applications
- Carcinogens and Genotoxicity Assessment
- Aluminum Alloys Composites Properties
- Tissue Engineering and Regenerative Medicine
- Anesthesia and Neurotoxicity Research
- Advanced Glycation End Products research
- Computational Drug Discovery Methods
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Arsenic contamination and mitigation
- Air Quality Monitoring and Forecasting
- Peroxisome Proliferator-Activated Receptors
- Pesticide and Herbicide Environmental Studies
- COVID-19 impact on air quality
- Neuroinflammation and Neurodegeneration Mechanisms
Shanxi University
2016-2025
Shanxi University of Traditional Chinese Medicine
2016-2025
Research Center for Eco-Environmental Sciences
2019-2023
Chinese Academy of Sciences
2019-2023
State Key Laboratory of Environmental Chemistry and Ecotoxicology
2022
Qingdao Agricultural University
2021
Beijing Administration Institute
2020
In-Q-Tel
2016
China Medical University
2012
PM2.5 (particulate matter ≤ 2.5 μm) is one of the leading environmental risk factors for global burden disease. Whereas increasing evidence has linked adverse roles with cardiovascular and respiratory diseases, limited but growing emerging suggests that exposure can affect nervous system, causing neuroinflammation, synaptic dysfunction cognitive deterioration. However, molecular mechanisms underlying deficits elicited by are largely unknown. C57BL/6 mice received oropharyngeal aspiration (1...
As a global problem, fine particulate matter (PM 2.5 ) really needs local fixes. Considering the increasing epidemiological relevance to anxiety and depression but inconsistent toxicological results, most important question is clarify whether how PM causally contributes these mental disorders which components are dangerous for crucial mitigation in particular place. In present study, we chronically subjected male mice real-world exposure system throughout winter heating period coal...
Abstract Air pollution has been reported to be associated with increased risks of cognitive impairment and neurodegenerative diseases. Because NO 2 is a typical primary air pollutant an important contributor secondary aerosols, -induced neuronal functional abnormalities have attracted greater attention, but the available experimental evidence, modulating mechanisms, targeting medications remain ambiguous. In this study, we exposed C57BL/6J APP/PS1 mice dynamic inhalation found for first time...
Tebuconazole, the most widely used fungicide, is reported to cause various environmental problems and have serious health risks in humans. Despite numerous advances toxicity studies, its internal metabolic process underlying mechanisms not been systemically studied. The present study administered low doses (0.02 g/kg bw 0.06 bw) of tebuconazole C57BL/6 mice vivo. high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed validated analyze different organs, our...
Tebuconazole, one of the most widely used triazole fungicides, is reported to potentially pose a risk inducing neurological disorders in human beings. Considering increasing exposure, whether it could influence cognitive function remains be elucidated. Herein, we mouse model evaluate potential risks and possible mechanisms from continuous edible application tebuconazole at low concentrations. Our study revealed that deteriorated spatial learning memory downregulated expression glutamate...
Particulate matter of size ≤ 2.5 μm (PM2.5) is a critical environmental threat that considerably contributes to the global disease burden. However, accompanied by rapid research progress in this field, existing on developmental toxicity still constrained limited data sources, varying quality, and insufficient in-depth mechanistic analysis. This review includes currently available epidemiological laboratory evidence comprehensively characterizes adverse effects PM2.5 developing individuals...
SO2, NO2, and PM2.5 are typical air pollutants produced during the combustion of coal. Increasing evidence indicates that pollution has contributed to development progression heart-related diseases over past decades. However, little experimental data few studies co-exposure in animals exist; therefore, relevant mechanisms underlying this phenomenon unclear. An important characteristic is persists at a low concentration throughout lifetime. In present study, we treated adult mice with various...
Because air pollution is a complex mixture of pollutants, understanding the health risks requires an evaluation their combined effects rather than predictions based on single chemicals alone.
The tremendous potential for graphene quantum dots (GQDs) in biomedical applications has led to growing concerns of their health risks human beings. However, present studies mainly focused on oxidative stress, apoptosis, and other general toxicity effects; the knowledge developmental related regulatory mechanisms is still far from sufficient. Our study revealed development retardation mouse embryonic stem cells (mESCs) caused by GQDs with a novel DNA methylation epigenetic mechanism....
Air pollution, especially from ultrafine particles (PM0.1, ≤0.1 μm), is increasingly recognized for its detrimental effects on health. The influence of PM0.1 neurodevelopmental disorders and underlying mechanisms remain incompletely understood but are significant concern. Through an investigation using mouse embryonic stem cells (mESCs), our study has uncovered disruptions in cell cycle dynamics, reduced neural precursor formation, impaired neurogenesis during mESC differentiation as a...
Multiple pollutants, usually at low levels, coexist and may interact in the environment. It is therefore important to analyze toxicity of mixtures coexisting chemicals evaluate potential ecological risk. Concern regarding co-occurrence combined bioeffects heavy metals organic insecticides aquatic settings has existed for many years, but a clear understanding interactions between these remains elusive. In present study, effects metal nickel (NiSO4) insect growth regulator buprofezin on...
The neurodevelopmental process is highly vulnerable to environmental stress from exposure endocrine-disrupting chemicals. Perfluorinated iodine alkanes (PFIs) possess estrogenic activities, while their potential toxicity remains blurry. In the present study, effects of two PFIs, including dodecafluoro-1,6-diiodohexane (PFHxDI) and tridecafluorohexyl iodide (PFHxI), were investigated in neural differentiation mouse embryonic stem cells (mESCs). Without influencing cytobiological mESCs, PFIs...