A5049674048- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Autism Spectrum Disorder Research
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Retinal and Optic Conditions
- Neuroscience of respiration and sleep
- Diet and metabolism studies
- Optical Imaging and Spectroscopy Techniques
- Optical Coherence Tomography Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Health, Education, and Aging
- Obsessive-Compulsive Spectrum Disorders
- Fish Biology and Ecology Studies
- Neonatal and fetal brain pathology
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Fish Ecology and Management Studies
- Cerebral Venous Sinus Thrombosis
- Attention Deficit Hyperactivity Disorder
- Neurological disorders and treatments
University of Coimbra
2018-2025
Deficits in the interpretation of others' intentions from gaze-direction or other social attention cues are well-recognized ASD. Here we investigated whether an EEG brain computer interface (BCI) can be used to train cognition skills ASD patients. We performed a single-arm feasibility clinical trial and enrolled 15 participants (mean age 22y 2m) with high-functioning full-scale IQ 103). Participants were submitted BCI training paradigm using virtual reality over seven sessions spread 4...
Autism spectrum disorder is characterized by abnormal function in core social brain regions. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback. Following up demonstration neuromodulation healthy participants, this repeated-measure design clinical trial, 15 autism patients were enrolled a 5-session training program neurofeedback targeting facial emotion expressions processing, using posterior superior temporal sulcus as...
How aging concomitantly modulates the structural integrity of brain and retina in healthy individuals remains an outstanding question. Given strong bottom-up retinocortical connectivity, it is important to study how these structures co-evolve during order unravel mechanisms that may affect physiological both structures. For 56 participants study, primary visual cortex (BA17), as well frontal, parietal temporal regions thicknesses were measured T1-weighted magnetic resonance imaging (MRI),...
The retina may serve as putative window into neuropathology of synaptic loss in Alzheimer’s disease (AD). Here, we investigated synapse-rich layers versus composed by nuclei/cell bodies an early stage AD. In addition, examined the associations between retinal changes and molecular structural markers cortical damage. We recruited 20 AD patients 17 healthy controls (HC). Combining optical coherence tomography (OCT), magnetic resonance (MR), positron emission (PET) imaging, measured primary...
One of the major obstacles to propagating dusky grouper, Epinephelus marginatus, is difficulty rearing early larvae. We have successfully raised grouper larvae in mesocosms using a mixed diet endogenous plankton grown tank and an exogenous supply Brachionus plicatilis Artemia sp. Newly hatched at initial density 1.3 ind.l-1 were stocked partially shaded 3 m3 circular outdoor tanks during summers 2007 2008. Before introducing newly larvae, water was left for six days promote growth. Larval...
Aims/Purpose: Neurovascular coupling (NVC) is the blood flow modulation in response to stimuli and has been extensively studied brain. Concerning human retina, this behaviour only measured ipsilateral eye, where observed effects involve same eye. This work aims set up hardware assess NVC contralateral eye demonstrate its feasibility edifying retina‐retina or cortico‐retinal connections. Methods: Adaptive optics (AO) a cutting‐edge technology retinal fundus imaging, offering exceptional...
Memory-related impairments in type 2 diabetes may be mediated by insulin resistance and hyperglycemia. Previous cross-sectional studies have controversially suggested a relationship between metabolic control decrease hippocampal volumes, but only longitudinal can test this hypothesis directly. We performed morphometric study to provide direct of possible role higher levels glycated hemoglobin with long term brain structural integrity key regions the memory system - hippocampus,...
Neurovascular coupling (NVC) in the brain is well studied and one of physical stimulation responses triggered by central nervous system. NVC, or functional hyperemia, described as local blood flow increase due to release vasodilator chemicals from neuronal cells into vessels. This behavior also exists retinal vasculature. However, it was only measured ipsilateral retina. Assessing photic contralateral retina can shed light on retina-retina brain-retina neural pathways. Emerging technologies...
Usher syndrome (USH) is a condition characterized by ciliary dysfunction leading to retinal degeneration and hearing/vestibular loss. Putative olfactory deficits in humans have been documented at the psychophysical level remain be proven neurophysiological level. Thus, we aimed study USH impairment using functional magnetic resonance imaging. We analyzed differences whole-brain responses between 27 patients 26 healthy participants during an detection task with bimodal odorant (n-butanol)....
Abstract Memory-related impairments in type 2 diabetes maybe be mediated by insulin resistance and hyperglycemia. Previous cross-sectional studies have controversially suggested a relationship between metabolic control decrease hippocampal volumes, but only longitudinal can test this hypothesis directly. We performed morphometric study to provide such direct of possible role higher levels glycated hemoglobin (HbA 1C) with long term brain structural integrity key regions the memory system –...