Background: Sepsis remains a significant contributor to illness and death in children. Studies suggests that potential benefits of zinc supplementation patients with sepsis, such as reduced inflammation mortality rates. Zinc is involved maintaining the structural integrity function cell membranes, which essential for proper signaling biomechanical responses. It can also influence activity key enzymes proteins regulate intracellular extracellular forces, thereby affecting adhesion, migration,...

Novel active-targeting nano-therapeutic, Temozolomide-loaded magnetosomes conjugate has been developed to address the challenges of high metastatic rates and recurrence tumors due tumor circulating cells. as drug were characterized through a scanning electron microscope, Zeta-sizer, UV-visible spectroscopy. The anti-tumor activity was studied in vitro (Cell viability, Cell proliferation, flow cytometry) vivo (Xenograft model). particle size temozolomide-coated is larger than that uncoated...

Metabolic acidosis in hemodialysis significantly affects morbidity and mortality. Understanding bicarbonate fluctuations is key to optimizing supplementation dialysis protocols. Objectives: To determine the inter-dialytic intra-dialytic changes serum level among patients undergoing maintenance hemodialysis. Methods: This quasi-experimental study was conducted at Nephrology Department, Fatima Jinnah Medical University (FJMU)/Sir Ganga Ram Hospital, Lahore, after taking synopsis approval from...

Hyperuricemia

To analyze risk factors and various nutrients associated with stunting among children aged 6-60 months.This is a case-control cross-sectional study between 40 cases controls. Data on possible were obtained through direct interviews using questionnaire. Examination of vitamin D, zinc, albumin, ferritin levels was performed both groups. analyzed IBM SPSS Statistics for Windows, Version 23.0 (IBM Co., Armonk, NY, USA) to determine assess the relationship nutritional stunting.The incidence...

Chronic Kidney Disease (CKD), as a worldwide health concern, results in several complications. Anemia caused by erythropoietin deficiency, reduced iron absorption, and abnormalities vitamin D metabolism are frequently seen children with CKD. Ferritin is the body's storage, whereas hepcidin protein that impacts metabolism. Low levels exacerbate heme deficiency anemia. This study aimed to know effect of D3 supplementation on serum ferritin A prospective cohort design was conducted Dr. Wahidin...

Typhoid fever, a systemic infection remains significant global health concern, especially in endemic areas. Typhidot and TUBEX-TF present quick, easy, cost-effective, however, their diagnostic performance still needs to be evaluated. This study aims evaluate accuracy for typhoid fever children using CRS composed of blood culture PCR recording its on days. was with cross-sectional design involving suspected aged 1 18 years, 7 hospitals South Sulawesi, Indonesia from November 2023 April 2024....

Abstract Injection of isologous monoclonal antibodies (SR2, SR3) caused anti‐glomerular basement membrane antibody‐induced glomerulonephritis (anti‐GBM nephritis) in WKY/NCrj rats. The were obtained from hybridoma cells derived fusion the spleen a nephritic ral injected with rat solubilized renal membranes adjuvant, and mouse SP2 myeloma cells. They belonged to IgG2a subclass bound kidney linear pattern along glomerular tubular membranes. Histological changes glomeruli detected at day 1...

Abstract In this study, to analyze the value of correlation between Urban Heat Island and land-use variables. Y variable used is temperature some variables X in form land use variants, namely road network area (km 2 ), population density / ha, building image index data from sentinel2 Landsat 8 time-series images satellite normalized difference vegetation (NDVI), Normalized Difference Water Index (NDWI) Moisture Indices (MI) Makassar City. The method study Pearson coefficient determine that...

This study aimed to observe the role of urinary kidney injury molecule (KIM-1), interleukin (IL-18), and insulin-like growth factor-binding protein 7 (IGFBP-7) levels in predicting acute (AKI) children with sepsis.This prospective cohort observational was conducted at Dr. RSUP. Wahidin Sudirohusodo, Makassar, South Sulawesi, from January December 2021. Inclusion criteria were septic patients treated pediatric intensive care unit (PICU) aged 1 month 18 years normal serum creatinine or urine...

Resistensi obat merupakan masalah kesehatan global, resistensi sendiri dapat terjadi secara alami namun penyalahgunaan antibiotik mempercepat terjadinya resistensi. Penyebab adalah dibeli bebas tanpa resep dokter. Sekiranya 2 juta individu terpapar dengan bakteri yang resisten pada setiap tahunnya di Amerika. Self medication pemakaian seseorang guna menyembuhkan gejala serta penyakit diketahui pribadi. Penggunaan mengalami peningkatan relatif tinggi. Sekitar 40-60% penggunaan tidak tepat,...

Introduction Dysregulated immune responses are developed in Coronavirus disease-2019 (COVID-19) and Interleukin-6 (IL-6) levels reflecting the severity of clinical presentation. This study aimed to analyze IL-6 serum level, Acute Respiratory Distress Syndrome (ARDS), Kidney Injury (AKI) as risk factors for mortality children with COVID-19. Methods prospective cohort was conducted on COVID-19 infection confirmed by Real Time Polymerase Chain Reaction (RT-PCR) who were admitted center at Dr....

Lactobacillus plantarum IS-10506 is a novel probiotic isolated from Indonesian traditional fermented buffalo milk dadih . Probiotics are clinically proven to be effective in accelerating recovery after urinary tract infection (UTI) and decreasing recurrent UTI children with or without structural disorders of the tract. This study aimed investigate role L. activating regenerating renal epithelial stem cells pyelonephritic rats. Fifty-five 20-weeks-old male Sprague-Dawley rats were randomised...

Background Acute glomerulonephritis (AGN) is a form of glom-erulonephritis characterized by sudden and explosive onset glom-erular injury symptom. It usually occurs after recent infection bygroup A beta-hemolytic streptococcus. AGN among Indonesianchildren seems to be less frequently reported than that othercountries.Objective To determine the current profile Indo-nesian children hospitalized in eleven teaching centers.Methods This was descriptive, cross-sectional study, based ona review...

Background Nephrotic syndrome is primarily a pediatric disorderand 15 times more common in children than adults.Relapse rate after corticosteroid discontinuation 39 - 59%.Hyperlipidemia an important characteristic of nephroticsyndrome. The plasma concentrations cholesterol, triglyceride,LDL, and VLDL are increased. Persistent hyperlipidemia afterremission can be found frequent relapse nephrotic syndrome.Objective To determine lipids as risk factor for relapsingnephrotic syndrome.Methods...

Background Urinary tract infections (UTI) is a common healthproblem in children. Its occurrence depends on several predis-posing factors and individual immunocompetence. Childrenwith protein energy malnutrition (PEM) have impaired immunefunction. Thus early detection prompt treatment of associatedinfections children with PEM are very important.Objective To determine the relationship between theoccurrence UTI children.Methods This cross sectional study conducted Dr. Wahidin Sud-irohusodo...

Abstract This study aims to analyze the compressive strength value of Senoni stone, East Kalimantan and its effect on water immersion. Free testing is carried out at 25oC. The number cylindrical cube specimens for free test each 3 specimens. Compressive using Universal Testing Machine (UTM). results showed that stones decreased due shows stone Senoni, not resistant water.

Cytoreduction has an important role in improving the survival rate of epithelial ovarian cancer (EOC) patients. This study aimed to assess ability preoperative serum CA125, FASN and GLS as predictors cytoreductive surgery for (EOC).The average values CA-125, FASN, suboptimal cytoreduction group were higher than those optimal group. The cut off point (COP) was 248.55 (p = 0.0001) with 73.2% sensitivity 73.6% specificity 0.445 0.017) 62.5% 60.4% 22.895 75.5% GLS. COP CA-125 combined 29.16...

Penyakit kusta menyerang saraf tepi dan kulit disebabkan oleh Myobacterium leprae. Reaksi dibagi menjadi 2 yaitu reaksi tipe 1 (reaksi reversal) (eritema nodusum leprosum). Masih terdapat wilayah di Indonesia yang belum mencapai status eliminasi khususnya Sulawesi Selatan. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik penderita Kusta rawat inap Rumah Sakit Umum Pusat Dr.Tadjuddin Chalid Makassar tahun 2021-2022. Metode penelitian digunakan adalah metode deskriptif cross...

Air Susu Ibu (ASI) adalah makanan terbaik untuk bayi baru lahir, cukup bulan (matur) maupun kurang (premature). Pemberian ASI ini diberikan sampai berusia 6 bulan. Setelah itu, harus diperkenalkan dengan padat yang disebut Makanan Pendamping (MPASI). MP-ASI atau minuman mengandung zat gizi, kepada anak usia 6-24 guna memenuhi kebutuhan gizi selain dari ASI. Hal dikarenakan hanya mampu duapertiga pada 6-9 bulan, dan 9-12 setengah bayi. Penelitian bertujuan mengetahui hubungan tingkat...

Abstract The influence of service quality has limited attention to the airport study. services are according demand that directly influences development airport. This study investigates increasing passengers used aircraft for mode choice transportation made polemic. with growing could satisfaction passenger use facilities and a flight. rising trend cover performance expansion analysis is conducted predict optimize According population daily flight information. Demand shows forecast...

Introduction: Acute Post Streptococcal Glomerulonephritis (APSGN) is one of the most common cause glomerular disease in children developing countries, including Indonesia. Therefore, it important to know various risk factors that affect incidence APSGN, so early diagnosis can be established. Materials and methods: A cross-sectional study was conducted identify APSGN children. The data were collected from medical records patients hospitalized inDr. Wahidin Sudirohusodo Hospital, Makassar...

We report the results of a retrospective study evaluating clinical edema and chest X-ray findings in 17b patients with acute poststreptococcal glomeru¬lonephritis (APSGN), hospitalized Pediatric Nephrology Unit Ujung Pandang General Hospital, from January 1, 1980 through December 31, 1990. Of total 194 patients, only 176 fulfilled criteria could be evaluated. There were 98 boys (55,7%) 78 girls (44.3%) aged between 1 year 9 months 14 years, mostly be¬tween 6-12 years (72.8%). found that...

Introduction: Idiopathic nephrotic syndrome (INS) is the most common kidney disease in children. Histopathological features classify into minimal change (MCNS) and non-minimal (NMCNS). Clinical laboratory characteristics are considered to be useful estimating underlying pathological changes. This study aimed assess spectrum of clinical profiles children suffering from MCNS NMCNS.
 Methods: was a cross-sectional using medical records patients hospitalized at Dr. Wahidin Sudirohusodo...