A5080119349- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Retinal Diseases and Treatments
- Protease and Inhibitor Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Calpain Protease Function and Regulation
- Neurogenetic and Muscular Disorders Research
- Nerve injury and regeneration
- Ophthalmology and Eye Disorders
- Corneal Surgery and Treatments
- Infrared Thermography in Medicine
- Optical measurement and interference techniques
- Satellite Image Processing and Photogrammetry
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Phytochemistry and Biological Activities
- Biochemical effects in animals
- Cerebrovascular and Carotid Artery Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Retinopathy of Prematurity Studies
- Nitric Oxide and Endothelin Effects
- Muscle Physiology and Disorders
University of Sheffield
2024-2025
Duke University
2006-2010
Duke Medical Center
2008-2010
Audie L. Murphy Memorial VA Hospital
2004-2005
The University of Texas Health Science Center at San Antonio
2003-2005
The University of Texas at San Antonio
2002-2004
Johns Hopkins University
1997
Mouse models of amyotrophic lateral sclerosis (ALS) enable testing novel therapeutic interventions. However, treatments that have extended survival in mice often failed to translate into human benefit clinical trials. Compound muscle action potentials (CMAPs) are a simple neurophysiological test measures the summation fiber depolarization response maximal stimulation innervating nerve. CMAPs can be measured both and humans decline with motor axon loss ALS, making them potential translational...
Abstract: M102 is a central nervous system (CNS) penetrant small molecule electrophile which activates in vivo the NFE2-related factor 2 antioxidant response element (NRF2-ARE) pathway, as well transcription of heat-shock (HSE) associated genes. In TDP-43Q331K transgenic mouse model ALS dosed subcutaneously at 5mg/kg OD or 2.5mg/kg BD with M102, significant improvements compound muscle action potential (CMAP) amplitude hind limb muscles and gait parameters were observed 6 months age, target...
Abstract Transgenic mouse models of amyotrophic lateral sclerosis, such as the widely used SOD1 G93A mouse, enable investigation disease mechanisms and testing novel therapeutic interventions. However, treatments that have been considered successful in mice often failed to translate into human benefit clinical trials, particularly when relying on so-called ‘survival’ read-out. Compound muscle action potentials (CMAPs), are a simple neurophysiological test measures summation fibre...
Glaucoma is a chronic neurodegeneration characterized functionally by initial loss of peripheral vision that may progress to blindness and structurally retinal ganglion cells (RGCs) optic nerve axons. Clinical measurement function performed subjective perimetry (visual fields), structure direct examination assessment longitudinal changes in color fundus photographs. Major risk factors for glaucoma include age, race, intraocular pressure (IOP). IOP the only FDA-approved factor amenable...
s from the 2000 Annual Meeting of American Glaucoma Society: Abstracts Sponsored by Pharmacia & Upjohn Peapack, New Jersey: PDF Only