A5014097613- Peptidase Inhibition and Analysis
- Oral Health Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mesenchymal stem cell research
- Protease and Inhibitor Mechanisms
- RNA modifications and cancer
- Oral and gingival health research
- Head and Neck Cancer Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Bone and Dental Protein Studies
- dental development and anomalies
- Proteoglycans and glycosaminoglycans research
- Angiogenesis and VEGF in Cancer
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Inflammatory mediators and NSAID effects
- Dental Radiography and Imaging
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- High Altitude and Hypoxia
- Endodontics and Root Canal Treatments
- Cancer, Lipids, and Metabolism
Shanghai Jiao Tong University
2005-2019
Shanghai Ninth People's Hospital
2006-2019
Abstract Background Oral cancer develops through multi-stages: from normal to mild (low grade) dysplasia (LGD), moderate dysplasia, and severe (high (HGD), carcinoma in situ (CIS) finally invasive oral squamous cell carcinomas (OSCC). Clinical histological assessments are not reliable predicting which precursor lesions will progress. The aim of this study was assess the potential a noninvasive approach progress risk precancerous lesions. Methods W e first used microRNA microarray profile...
Abstract Background Our previous studies showed that Salvianolic acid B (Sal B) inhibited 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters and such anti-cancer effects might be related to the inhibition of angiogenesis. This study was aimed further investigate anti-proliferative effect Sal on most common type cancer, squamous cell carcinoma (OSCC) possible mechanisms action with respect angiogenesis inhibition. Methods Two well-characterized lines, CAL27 SCC4,...
MicroRNA-519d (miR-519d) has been reported to play important roles in tumor development and progression multiple cancers, either as suppressor or promotor. However, the expression level, biological function molecular mechanisms of miR-519d oral squamous cell carcinoma (OSCC) remain unclear. Therefore, aims this study were investigate functional role OSCC possible underlying regulatory mechanism. In study, we found that was significantly downregulated tissues lines compared with normal...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide, exhibiting high morbidity mortality. The prognosis HNSCC patients has remained poor, though considerable efforts have been made to improve treatment this cancer. Therefore, identifying significant differentially expressed genes (DEGs) involved in progression exploiting them as novel biomarkers or potential therapeutic targets for highly valuable. Methods Overlapping were screened...
Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with high morbidity mortality rates ranks as the sixth most common cancer all over world. Despite numerous advancements in therapeutic methods, prognosis of HNSCC patients still remains poor. Therefore, there urgent need to have a better understanding molecular mechanisms underlying progression identify essential genes that could serve effective biomarkers potential treatment targets. In present study, original data...
A decrease in the almost fifty percent mortality rate from oral cancer is needed urgently. Improvements early diagnosis and more effective preventive treatments could affect such a decrease. Towards this end, we undertook for first time an in-depth mass spectrometry-based quantitative shotgun proteomics study of non-invasively collected brush biopsies. Proteins isolated biopsies healthy normal tissue, premalignant lesion tissue (OPMLs), squamous cell carcinoma (OSCC) matched control were...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide human papillomavirus (HPV) has been increasingly recognized as a pathogenic factor for initiation development of HNSCC. E6 oncogene, an essential component HPV 16 virus, acts leading cause malignant transformation cells. Therefore, investigating biological effect potential mechanisms oncogene on HNSCC cells exploring therapeutic methods great value.MTT assay, cycle analysis, apoptosis assay were...
Genistein, an isoflavone present in soy at high concentrations and being considered the primary antitumor constituent soy, has been known to be a natural anticancer agent vitro studies experimental animal models. The study was aimed investigate putative chemopreventive effect of genistein on oral carcinogenesis hamster cheek pouch post-initiation stage, as well its angiogenesis during this process. DMBA solution (0.5% mineral oil) applied topically left male Syrian golden hamsters three...
Oral leukoplakia (OL) is one of the most common oral precancerous lesions with possibility malignant transformation, ranging from 17 to 24% patients a median follow-up >7 years. Previous research has revealed that compared normal epithelial tissues, expression secretory leukocyte peptidase inhibitor (SLPI) protein significantly reduced in squamous cell carcinoma (OSCC). Based on above-mentioned research, it known SLPI potential predictive and diagnostic tool for progression carcinogenesis....