A5086576933- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Genetic and Kidney Cyst Diseases
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Dietary Effects on Health
- Knee injuries and reconstruction techniques
- Renal and related cancers
- Cell Adhesion Molecules Research
- Climate Change and Health Impacts
- Inflammatory mediators and NSAID effects
- Urological Disorders and Treatments
- Bone health and osteoporosis research
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Air Quality and Health Impacts
- Connective tissue disorders research
- Total Knee Arthroplasty Outcomes
- Bone health and treatments
- Energy and Environment Impacts
- Lower Extremity Biomechanics and Pathologies
- Mesenchymal stem cell research
Anglia Ruskin University
2021-2025
University of Brighton
2020-2022
University of Sheffield
2020-2021
Versus Arthritis
2020-2021
Edinburgh Napier University
2020
Abstract Tartrate-resistant acid phosphatase (TRAP) is an enzyme predominantly expressed in osteoclasts, where it plays a pivotal role bone remodeling. Deficiency TRAP leads to severe skeletal impairments such as osteopetrosis humans and mice. While mechanical loading known promote mass growth, the of this adaptive process remains unclear. Here, we applied axial tibial micro-computed tomography analysis investigate differences anabolic response sixteen-week-old male knockout (TRAP−/−)...
Tartrate-resistant acid phosphatase (TRAP) serum levels reflect osteoclast number, bone remodeling activity, and fracture risk. Deletion or loss of function TRAP results in short stature mice man. Yet, the impact mechanisms for site- sex-specific development cartilage is not well understood. Here, we use a global knockout (TRAPKO) wildtype littermate control (WT) both sexes to investigate as possible sex- site-specific regulator growth plate development. TRAPKO weighed less had shorter...
The purpose of this study was to investigate growth plate dynamics in surgical and loading murine models osteoarthritis, understand whether abnormalities these are associated with osteoarthritis development. 8-week-old C57BL/6 male mice underwent destabilisation medial meniscus (DMM) ( n = 8) surgery right knee joints. Contralateral left joints had no intervention (controls). In 16-week-old 6), induced using non-invasive mechanical peak force 11N. Non-loaded were internal controls....
Aims Osteoarthritis (OA) is the most prevalent systemic musculoskeletal disorder, characterized by articular cartilage degeneration and subchondral bone (SCB) sclerosis. Here, we sought to examine contribution of accelerated growth OA development using a murine model excessive longitudinal growth. Suppressor cytokine signalling 2 (SOCS2) negative regulator hormone (GH) signalling, thus mice deficient in SOCS2 ( Socs2 -/- ) display Methods We examined vulnerability following surgical...
ObjectiveTo examine the relationship between height gain across childhood and adolescence with knee osteoarthritis in MRC National Survey of Health Development (NSHD).Materials methodsData are from 3035 male female participants NSHD. Height was measured at ages 2, 4, 6, 7, 11 15 years, self-reported 20 years. Associations (1) each age (2) during specific life periods (3) Super-Imposition by Translation And Rotation (SITAR) growth curve variables size, tempo velocity, 53 years were...
ABSTRACT Compared with our understanding of endochondral ossification, much less is known about the coordinated arrest growth defined by narrowing and fusion cartilaginous plate. Throughout musculoskeletal system, appropriate cell tissue responses to mechanical force delineate morphogenesis ensure lifelong health. It remains unclear how cues are integrated into many biological programs, including those coordinating ossification adolescent plate at cessation growth. Primary cilia...
The benefits of increased human lifespan depend upon duration healthy, independent living; the healthspan. Bone-wasting disorders contribute significantly to loss independence, frailty, and morbidity in older people. Therefore, there is an unmet need globally for lifestyle interventions reduce likelihood bone fractures with age. Although many mechanisms are involved loss, no single regulatory pathway and, therefore, treatment available prevent their occurrence. Our aim these studies was...
Abstract Objectives To examine the relationship between height gain across childhood and adolescence with knee osteoarthritis in MRC National Survey of Health Development (NSHD). Methods Data are from 3035 male female participants NSHD. Height was measured at ages 2, 4, 6, 7, 11 15 years, self-reported 20 26 years. Associations (i) each age (ii) during specific life periods (iii) Super-Imposition by Translation And Rotation (SITAR) growth curve variables size, tempo velocity, 53 years were...
Abstract In the musculoskeletal system, appropriate cell and tissue responses to mechanical force delineate morphogenesis ensure lifelong health. Despite this, how cues are integrated into biological programmes remains unclear. Primary cilia microtubule-based organelles that tune a range of activities, including signalling cascades activated or modulated, by extracellular biophysical cues. Here, we demonstrate inducible, cartilage-specific deletion Intraflagellar transport protein 88...
Abstract Background The purpose of this study was to investigate growth plate dynamics in surgical and loading murine models osteoarthritis, understand whether abnormalities these predict osteoarthritis vulnerability. Methods 8-week-old C57BL/6 male mice underwent destabilisation medial meniscus (DMM) ( n = 8) surgery right knee joints. Contralateral left joints had no intervention (controls). In 16-week-old 6), induced using non-invasive mechanical with peak force 11N. Non-loaded were...
Abstract The benefits of increased human lifespan depend upon duration healthy, independent living; the healthspan. Bone-wasting disorders contribute significantly to loss independence, frailty and morbidity in older people. Therefore, there is an unmet need globally for lifestyle interventions reduce likelihood bone fractures with age. Although many mechanisms are involved loss, no single regulatory pathway and, therefore, treatment available prevent their occurrence. Our aim these studies...
Abstract Osteoarthritis is the most prevalent systemic musculoskeletal disorder characterised by articular cartilage degeneration and subchondral bone (SCB) sclerosis. Here we sought to examine contribution of accelerated growth osteoarthritis development using a murine model excessive longitudinal growth. Suppressor cytokine signalling 2 (SOCS2) negative regulator hormone (GH) signalling, thus mice deficient in SOCS2 ( Socs2 -/- ) display We examined vulnerability following surgical...