A5077194189- T-cell and B-cell Immunology
- Fatty Acid Research and Health
- Aquaculture Nutrition and Growth
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Metabolism and Genetic Disorders
- Seaweed-derived Bioactive Compounds
- Cardiac pacing and defibrillation studies
- Meat and Animal Product Quality
- Cardiac Arrhythmias and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Lipid Membrane Structure and Behavior
- Cardiovascular Function and Risk Factors
- Echinoderm biology and ecology
- Retinal Diseases and Treatments
- Insect and Pesticide Research
- Marine animal studies overview
- Metabolomics and Mass Spectrometry Studies
- Atrial Fibrillation Management and Outcomes
- Marine and coastal plant biology
- Adipose Tissue and Metabolism
- Marine Bivalve and Aquaculture Studies
- RNA regulation and disease
- Coffee research and impacts
University of Aveiro
2018-2025
Rede de Química e Tecnologia
2020-2025
Escola Universitária Vasco da Gama
2024-2025
University of Coimbra
2003-2024
Stanford University
2023-2024
Palo Alto University
2024
Medtronic (United States)
2016-2022
Northwestern University
2020
National Institute of Allergy and Infectious Diseases
2012-2016
National Institutes of Health
2012-2016
Hospital admissions are frequently preceded by increased pulmonary congestion in heart failure (HF) patients. This study evaluated whether early automated fluid status alert notification via telemedicine improves outcome HF Patients recently implanted with an implantable cardioverter defibrillator (ICD) or without cardiac resynchronization therapy were eligible if one of three conditions was met: prior hospitalization, recent diuretic treatment, brain natriuretic peptide increase. Eligible...
Naïve T cells continually recirculate between blood and secondary lymphoid organs, scanning dendritic (DC) for foreign antigen. Despite its importance understanding how adaptive immune responses are efficiently initiated from rare precursors, a detailed quantitative analysis of this fundamental process has not been reported. Here we measure lymph node (LN) entry, transit, exit rates naïve CD4 + CD8 cells, then use intravital imaging mathematical modeling to relate cell–cell interaction...
Generation of a self-tolerant but antigen-responsive T cell repertoire occurs in the thymus. Although glucocorticoids are usually considered immunosuppressive, there is also evidence that they play positive role thymocyte selection. To address question how endogenous might influence adaptive immune response, we generated GRlck-Cre mice, which glucocorticoid receptor gene (GR) deleted thymocytes prior to These mice were immunocompromised, with reduced polyclonal proliferative responses...
Bone metastases, present in 70% of patients with metastatic breast cancer, lead to skeletal disease, fractures and intense pain, which are all believed be mediated by tumor cells. Engraftment cells is supposed preceded changes the target tissue create a permissive microenvironment, pre-metastatic niche, for establishment foci. In bone stimulate consumption resulting release growth factors that feed tumor, establishing vicious cycle between remodeling system itself. Yet, how niches arise...
Background Physical activity data are collected automatically by implantable cardioverter‐defibrillators ( ICD s). Though these potentially provide a quantifiable and easily accessible measure of functional status, its relationship with survival has not been well studied. Methods Results Patients enrolled in the Boston Scientific LATITUDE remote monitoring system from 2008 to 2012 s were eligible. Remote used calculate mean daily at baseline (30 60 days after implantation), longitudinally....
Background: Long-term exposure to particulate matter (PM) air pollution is associated with all-cause mortality and adverse cognitive outcomes, but the association developing depression remains inconsistent. Objective: Our goal was evaluate prospective between PM assessed using Center for Epidemiological Studies Depression (CES-D) scale. Methods: Subjects were drawn from a cohort study of 123,045 men women free depressive symptoms at baseline who attended regular screening exams in Seoul...
The aquaculture of macroalgae for human consumption and other high-end applications is experiencing unprecedented development in European countries, with the brown algae Saccharina latissima being flag species. However, environmental conditions open sea culture sites are often unique, which may impact biochemical composition cultured macroalgae. present study compared elemental compositions (CHNS), fatty acid profiles, lipidomes S. originating from three distinct locations (France, Norway,...
Brown seaweeds are known to present components with appealing bioactive properties eliciting great interest for industrial applications. However, their lipid content is generally disregarded beyond fatty acid (FA) composition. This study thoroughly characterized the profile of two brown collected from Portuguese coast, native Bifurcaria bifurcata and invasive Sargassum muticum species, bioprospecting antioxidant activity. An integrated state-of-the-art approach including gas...
Macroalgae aquaculture is thriving, and kelps such as Saccharina latissima, are now farmed over different production sites across Europe. in integrated multi-trophic setups gaining relevance due to increased biomass yield bioremediation potential. Nevertheless, there a substantiated need understand how this type of shapes composition. The present study evaluated the influence time harvesting proximity nutrient source (fish farm sea cages) on elemental biochemical composition S. with special...