A5066326666- Microbial Metabolism and Applications
- Bacterial biofilms and quorum sensing
- Gut microbiota and health
- Amphibian and Reptile Biology
- Cell Image Analysis Techniques
- Antimicrobial Peptides and Activities
- Environmental DNA in Biodiversity Studies
- Turtle Biology and Conservation
- Microbial Community Ecology and Physiology
- Distributed and Parallel Computing Systems
- Genomics and Phylogenetic Studies
- Research Data Management Practices
- Rabies epidemiology and control
- Scientific Computing and Data Management
- Bacterial Identification and Susceptibility Testing
- Insect and Arachnid Ecology and Behavior
- Photodynamic Therapy Research Studies
- Leptospirosis research and findings
- Cancer Research and Treatments
- Evolutionary Game Theory and Cooperation
- Viral Infections and Vectors
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Species Distribution and Climate Change
Smithsonian Conservation Biology Institute
2024
National Zoological Park
2024
Conservation Biology Institute
2024
University of Massachusetts Boston
2021-2024
University of South Dakota
2017-2022
Mayo Clinic
2019-2021
Mayo Clinic in Arizona
2021
Mayo Clinic in Florida
2020
WinnMed
2019
Global amphibian declines and extinction events are occurring at an unprecedented rate. While several factors responsible for extinction, the fungal pathogen Batrachochytrium dendrobatidis (Bd) has been cited as a major constituent in these events. effects of this chytrid fungus have shown to cause broad scale population extinctions, certain individuals relict populations resistance. This resistance attributed part cutaneous bacterial microbiome. Here we present first study characterizing...
ObjectiveTo determine whether analysis of methylated DNA in benign endometrial biopsy (EB) specimens is associated with risk cancer (EC).MethodsWe identified 23 women EBs performed at Mayo Clinic diagnosed as normal (n = 14) or hyperplasia 9) and who later developed after a median interval 1 year. Cases were matched 1:1 patients did not develop EC (controls) by histology EB (normal endometrium vs. without atypia), date EB, age length post-biopsy follow-up. extracted from formalin-fixed...
Abstract Accurate pathogen detection is essential for developing management strategies to address emerging infectious diseases, an increasingly prominent threat wildlife. Sampling free‐living pathogens outside of their hosts has benefits inference and study efficiency, but still uncommon. We used a laboratory experiment evaluate the influences concentration, water type, qPCR inhibitors on quantification Batrachochytrium dendrobatidis ( Bd ) using filtration. compared results pre‐...
Ongoing investigations into the interactions between microbial communities and their associated hosts are changing how emerging diseases perceived ameliorated. Of numerous host–microbiome–disease systems of study, emergence chytridiomycosis (caused by Batrachochytrium dendrobatidis , hereafter Bd ) has been implicated in ongoing declines extinction events amphibians worldwide. Interestingly, there differential survival among resisting infection subsequent disease. One factor thought to...
Recent evidence suggests an association between endometrial cancer and the understudied bacterial species Porphyromonas somerae . This was demonstrated in previous work that indicated a significantly enriched abundance of P. uterine microbiome patients. Given known associations genus oral cancer, we hypothesized may play similar pathogenic role via intracellular activity. Before testing our hypothesis, first characterized biology, as current background data is limited. These novel...
Abstract Leptospirosis (caused by pathogenic bacteria in the genus Leptospira ) is prevalent worldwide but more common tropical and subtropical regions. Transmission can occur following direct exposure to infected urine from reservoir hosts, such as rats, or a urine-contaminated environment, which then serve an infection source for additional rats other mammals, including humans. The brown rat, Rattus norvegicus , important of leptospirosis urban settings. We investigated among Boston,...
The use of museum specimens for research in microbial evolutionary ecology remains an under-utilized investigative dimension with important potential. Despite this potential, there remain barriers methodology and analysis to the wide-spread adoption such studies. Here, we hypothesized that would be significant differences taxonomic prediction related diversity among sample type (museum or fresh) sequencing strategy (medium-depth shotgun metagenomic 16S rRNA gene). We found dramatically...
Understanding how environmental factors influence various aspects of freshwater turtle health remains an important yet understudied topic within the context individual–environment interactions. This is particularly true host-associated bacterial microbiota, which are being increasingly recognized as a significant and in individual health. While this area work has expanded certain areas, research efforts remain limited with regard to host–microbiota interactions habitat contaminants....
Turtle populations around the world are continually confronted with changing environments that affect their ecology and conservation status. Among freshwater turtles, population dynamics thought to be mediated by complex yet often cryptic causes. One recent direction of focus in addressing these causes is turtle-associated microbiota. In gut-associated microbiota exceptional interest due its continual association host species under conditions. Diet-based fluctuations changes microbial...
The use of museum specimens for research in microbial ecology and evolution remains an under-utilized investigative dimension with important potential. Despite this potential, there remain methodological barriers to wide-spread adoption studies. One these is the difference predictive abilities among nucleic acid based methods taxonomic categorization, include differing sequencing reference databases. In study, we hypothesized that would be differences categorization related diversity results...
Science Gateways are virtual environments that accelerate scientific discovery by enabling communities to more easily and effectively utilize distributed computing data resources. Successful provide access sophisticated powerful resources, while shielding their users from the underlying complexities. Here we present work completed University of South Dakota (USD) Research Computing Group in conjunction with Community Institute (SGCI) [1] Indiana on setting up a Gateway USD's high-performance...
Science Gateways are virtual environments that accelerate scientific discovery by enabling communities to more easily and effectively utilize distributed computing data resources. Successful provide access sophisticated powerful resources, while shielding their users from the underlying complexities. Here we present updated work completed University of South Dakota (USD) Research Computing Group in conjunction with Community Institute (SGCI) [1] Center at Indiana set up a Gateway USD's...