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A5028017670
Research Areas
- Computational Drug Discovery Methods
- Malaria Research and Control
- Mosquito-borne diseases and control
The mechanism of action artemisinin and its derivatives, the most potent anti-malarial drugs, is not completely understood. Here we present an unbiased chemical proteomics analysis to directly explore this in Plasmodium falciparum. We use alkyne-tagged analogue coupled with biotin identify 124 covalent binding protein targets, many which are involved essential biological processes parasite. Such a broad targeting spectrum disrupts biochemical landscape parasite causes death. Furthermore,...
10.1038/ncomms10111
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Nature Communications
2015-12-22
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