A5006099843- Genetic and Kidney Cyst Diseases
- Biomedical Research and Pathophysiology
- Autophagy in Disease and Therapy
- Renal and related cancers
- Genetic Syndromes and Imprinting
- Gout, Hyperuricemia, Uric Acid
- Pancreatic function and diabetes
- Folate and B Vitamins Research
- Hedgehog Signaling Pathway Studies
- Dietary Effects on Health
- Cell death mechanisms and regulation
- Metabolism and Genetic Disorders
- Carcinogens and Genotoxicity Assessment
- Metabolism, Diabetes, and Cancer
- Calcium signaling and nucleotide metabolism
- Renal Diseases and Glomerulopathies
- Adenosine and Purinergic Signaling
- Multiple and Secondary Primary Cancers
- Childhood Cancer Survivors' Quality of Life
- Liver Disease Diagnosis and Treatment
- Nuclear Receptors and Signaling
- Blood groups and transfusion
- Neurological and metabolic disorders
- Phagocytosis and Immune Regulation
- Urticaria and Related Conditions
University of Colorado Anschutz Medical Campus
2020-2024
University of Colorado Denver
2019-2023
University of Colorado Health
2022
Istanbul University
2022
Autosomal dominant polycystic kidney disease (PKD) is characterized by cyst formation and growth, which are partially driven abnormal proliferation of tubular cells. Proproliferative mechanistic target rapamycin (mTOR) complexes 1 2 (mTORC1 mTORC2) activated in the kidneys mice with PKD. Sirolimus indirectly inhibits mTORC1. Novel mTOR kinase inhibitors directly inhibit kinase, resulting inhibition mTORC1 mTORC2. The aim present study was to determine effects sirolimus versus inhibitor...
Humans are predisposed to gout because they lack uricase that converts uric acid allantoin. Rodents have uricase, resulting in low basal serum acid. A inhibitor raises rodents. There were two aims of the study polycystic kidney disease (PKD):
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease, characterized by cyst formation and growth. Hyperproliferation a major contributor to At nexus of regulating proliferation, 4E-BP1. We demonstrate that ADPKD mouse rat models, patient biopsies PKD1-/- cells exhibited hyperphosphorylated 4E-BP1, biomarker increased translation proliferation. hypothesized expression constitutively active 4E-BP1 constructs (4E-BP1F113A 4E-BP1R13AF113A) would...
Abstract Many surgical models are used to study kidney and other diseases in mice, yet the effects of procedure itself on tissues have not been elucidated. In present study, we found that both sham surgery unilateral nephrectomy (UNX), which is as a model renal compensatory hypertrophy, mice resulted increased mammalian target rapamycin complex 1/2 (mTORC1/2) remaining kidney. mTORC1 known regulate lysosomal biogenesis autophagy. Genes associated with function were decreased UNX kidneys....
Metformin (MET) has the potential to activate p-AMPK and block mTORC1-induced proliferation of tubular cells in PKD kidneys. The aim this study was determine effects MET on cyst growth, kidney function, AMPK mTOR signaling, lactate levels male PCK rats, a Pkhd1 gene mutation model human autosomal recessive polycystic disease (ARPKD). 300 mg/kg/day IP from days 28 84 age resulted mean serum metformin level that 10 times upper limit therapeutic, no effect indices, nephrotoxicity, increased...
Atwood, Daniel; Chaudhary, Anjana; He, Zhibin; Oto, Ozgur A.; Edelstein, Charles L. Author Information
Chaudhary, Anjana; He, Zhibin; Atwood, Daniel; Davidoff, Allen; Edelstein, Charles L. Author Information
Brown, Carolyn N.; Atwood, Daniel; Pokhrel, Deepak; Altmann, Chris; Faubel, Sarah; Edelstein, Charles L. Author Information
Atwood, Daniel; Pokhrel, Deepak; Brown, Carolyn N.; Hopp, Katharina; Edelstein, Charles L. Author Information
Atwood, Daniel; Brown, Carolyn N.; Hopp, Katharina; Edelstein, Charles L. Author Information
Atwood, Daniel; Pokhrel, Deepak; Dwivedi, Nidhi; Hopp, Katharina; Edelstein, Charles L. Author Information
Journal of the American Society Nephrology 32(10S):p 399, October 2021. | DOI: 10.1681/ASN.20213210S1399a