A5025827079- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Cellular transport and secretion
- Neuroendocrine regulation and behavior
- Autophagy in Disease and Therapy
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Neurological Disorders and Treatments
- Neuroscience and Neural Engineering
- Sulfur Compounds in Biology
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Pharmacological Effects and Toxicity Studies
- Hypothalamic control of reproductive hormones
- Calcium signaling and nucleotide metabolism
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Cellular Mechanics and Interactions
- Photoreceptor and optogenetics research
Columbia University
2021-2022
Leibniz Institute for Neurobiology
2009-2021
Center for Behavioral Brain Sciences
2021
James A. Haley Veterans' Hospital
2012
University of South Florida
2012
Florida College
2012
Instituto de Neurologia Y Neurocirugia
2007
International Center of Neurologic Restoration
2007
The hippocampus is essential for different forms of declarative memory, including social the ability to recognize and remember a conspecific. Although recent studies identify importance dorsal CA2 region in memory storage, little known about its sources information. Because CA2, like other hippocampal regions, receives major source spatial non-spatial information from medial lateral subdivisions entorhinal cortex (MEC LEC), respectively, we investigated these inputs memory. Whereas MEC are...
Amphisomes are organelles of the autophagy pathway that result from fusion autophagosomes with late endosomes. While biogenesis and endosomes occurs continuously at axon terminals, non-degradative roles boutons barely described. Here, we show in neurons BDNF/TrkB traffick amphisomes signal locally presynaptic during retrograde transport to soma. This is orchestrated by Rap GTPase-activating (RapGAP) protein SIPA1L2, which connects TrkB a dynein motor. The autophagosomal LC3 regulates RapGAP...
Neurons are highly polarized cells with apparent functional and morphological differences between dendrites axon. A critical determinant for the molecular identity of axonal dendritic segments is restricted expression voltage-gated ion channels. Several studies show an uneven distribution channels their differential regulation within axons, which a prerequisite appropriate integration synaptic inputs generation adequate action potential firing patterns. This review will focus on signaling...
Abstract The dentate gyrus is the main entry gate for cortical input to hippocampus and one of few brain areas where adult neurogenesis occurs. Several studies have shown that it relatively difficult induce synaptic plasticity in mature but not newborn granule cells. In present work we systematically addressed how classical protocols affect action potential firing intrinsic excitability We found stimulation paradigms considered be relevant learning processes consistently modified probability...
Jacob, the protein encoded by Nsmf gene, is involved in synapto-nuclear signaling and docks an N-Methyl-D-Aspartate receptor (NMDAR)-derived signalosome to nuclear target sites like transcription factor cAMP-response-element-binding (CREB). Several reports indicate that mutations NSMF are related Kallmann syndrome (KS), a neurodevelopmental disorder characterized idiopathic hypogonadotropic hypogonadism (IHH) associated with anosmia or hyposmia. It has also been reported knockdown results...
Mature granule cells are poorly excitable neurons that were recently shown to fire action potentials, preferentially in bursts. It is believed the particularly pronounced short-term facilitation of mossy fiber synapses makes cell bursting a very effective means properly transferring information CA3. However, mechanism underlying unique behavior mature currently unknown. Here, we show Cav3.2 T-type channels at axon initial segment responsible for burst firing rats and mice. Accordingly,...
Abstract Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. Katanin, a heterodimer, consisting of catalytic (p60) and regulatory (p80) subunits severs dynamic microtubules to modulate several stages cell division. The role p60 katanin in the mammalian brain with respect embryonic adult neurogenesis is poorly understood. Here, we generated Katna1 knockout mouse found that consistent critical mitosis, constitutive homozygous depletion lethal....
The capacity to distinguish comparable experiences is fundamental for the recall of similar memories and has been proposed require pattern separation in dentate gyrus (DG). However, cellular mechanisms by which mature granule cells (GCs) DG accomplish this function are poorly characterized. Here, we show that Kv4.2 channels selectively modulate excitability medial dendrites GCs. These targeted entorhinal cortex, main source spatial inputs DG. Accordingly, found capability animals lacking...
Abstract The storage of information by the hippocampus in long-term memory is thought to involve two distinct but related processes. First, determines whether a given stimulus novel or familiar; next, stores memory. To date, neural circuits that detect novelty and their relation store specific are poorly understood. Here we address this question examining which CA2 region hippocampus, essential for social memory, both detects CA2, like more thoroughly studied CA1 region, receives its major...
Summary Amphisomes are transient organelles that derive from fusion of autophagosomes with late endosomes. They rapidly transform into degradative autolysosomes, whereas non-degradative roles the autophagic pathway have been barely described. Here we show in neurons BDNF/TrkB receptor bearing Rab7 / Light chain 3 (LC3) - positive amphisomes signal at presynaptic boutons during retrograde trafficking to soma. Local signaling and inward transport essentially require Rap GTPase-activating...