A5006066691- Semiconductor Quantum Structures and Devices
- Semiconductor materials and devices
- Advanced Semiconductor Detectors and Materials
- Magnetic properties of thin films
- Advanced Fiber Optic Sensors
- Photonic and Optical Devices
- Quantum and electron transport phenomena
- Wind Energy Research and Development
- Nanowire Synthesis and Applications
- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor Lasers and Optical Devices
- Quantum Dots Synthesis And Properties
- Wind and Air Flow Studies
- Computational Fluid Dynamics and Aerodynamics
- Semiconductor materials and interfaces
- Metal and Thin Film Mechanics
- Ion channel regulation and function
- Turbomachinery Performance and Optimization
- Copper Interconnects and Reliability
- Cardiac electrophysiology and arrhythmias
- Surface and Thin Film Phenomena
- Fluid Dynamics and Turbulent Flows
- Enzyme Structure and Function
- Advanced MEMS and NEMS Technologies
- Electronic and Structural Properties of Oxides
University of Massachusetts Amherst
2023-2024
University of Iowa
2012-2021
Sandia National Laboratories
1993-2015
University of Utah
2001-2014
University of Idaho
2004-2011
Material Sciences (United States)
2009
University of California, Santa Barbara
1989-2005
Virginia Tech
1980-2005
Lund University
1994-2002
Dynetics (United States)
1986-2000
Polycystic kidney disease (PKD) is a common human genetic illness. It characterized by the formation of multiple cysts that are thought to result from over-proliferation epithelial cells. Zebrafish larvae can also develop cysts. In an insertional mutagenesis screen in zebrafish, we identified 12 genes cause glomerular-tubular region when mutated and cloned 10 these genes. Two genes, vhnf1(tcf2) pkd2, already associated with cystic diseases. Recently, defects primary cilia have been linked...
Optical emission from individual strained indium arsenide (InAs) islands buried in gallium (GaAs) was studied. At low excitation power density, the spectra these quantum dots consist of a single line. higher additional lines appeared at both and lower energies, separated main line by about 1 millielectron volt. even this set replaced broad peaking below original The splittings were an order magnitude smaller than lowest single-electron or single-hole excited state indicating that fine...
Experimental methods for the practical implementation of few-mode elliptical-core sensors are described. Techniques desensitizing lead-in and lead-out fibers discussed, results a vibration sensor embedded in graphite-epoxy composite presented. A scheme using single-mode fiber as an offset circular-core is successfully implemented. Detection techniques reviewed, novel fringe-counting method to unambiguously detect amplitude direction dynamic strain reported.< <ETX...
GLYCAM06 and CHARMM36 are successful force fields for modeling carbohydrates. To correct recently identified deficiencies with both fields, we adjusted intersolute nonbonded parameters to reproduce the experimental osmotic coefficient of glucose at 1 M. The modified improve behavior sucrose up 4 M a dextran 55-mer. While may not be applicable all carbohydrates, they highlight use simulations optimize fields.
A serpentine superlattice quantum-wire array avoids the tilt sensitivity of a tilted and promises significant 1D confinement at 10 nm scale. Transmission electron micrographs confirm intended geometry. Three independent polarization measurements, an energy shift, light-hole--heavy-hole splitting 1.4 K, when compared with theory demonstrate valence band states 2D conduction states. All five measurements are explained by lateral...
The assembly of strained InAs islands was manipulated through growth on patterned GaAs substrates with chemical beam epitaxy. Conditions were found to selectively place the in patterns features but not surrounding unpatterned fields. Chains having 33 nm minimum periods formed trenches, and single or few grown arrays holes. When capped GaAs, behave as quantum dots are optically active.
Intraflagellar transport (IFT) particles of Chlamydomonas reinhardtii contain two distinct protein complexes, A and B, composed at least 6 15 subunits, respectively. As isolated from C. flagella, IFT complex B can be further reduced to a approximately 500-kDa core that contains IFT88, 2x IFT81, IFT74/72, IFT52, IFT46, IFT27, IFT25, IFT22. In this study, yeast-based two-hybrid analysis was combined with bacterial coexpression show three the interact directly each other and, together, are...
Riboflavin-binding protein (RBP) and phosvitin are phosphoglycoproteins transferred from the plasma of laying hens into yolk developing oocytes. We have examined effect phosphate removal on this deposition process. Unmodified RBP contain, respectively, 8.3 109 residues phosphate/molecule. Complete dephosphorylation caused a 20-min decrease in clearance half-life an 87% uptake oocytes vivo. Although partially desialylated, dephospho-yolk was identical with native by several criteria,...
AMBER/GLYCAM and CHARMM are popular force fields for simulations of amino acids sugars. Here we report excessively attractive acid-sugar interactions in both fields, corrections to nonbonded that match experimental osmotic pressures mixed aqueous solutions diglycine sucrose. The modified parameters also improve the ΔG
There is a small, but growing, body of literature describing the use osmotic coefficient measurements to validate and reparametrize simulation force fields. Here we have investigated ability five very commonly used field water model combinations reproduce coefficients seven neutral amino acids small molecules. The fields tested include AMBER ff99SB-ILDN, CHARMM36, GROMOS54a7, OPLS-AA, with first these in conjunction TIP3P TIP4P-Ew models. In general, for both molecules, produce computed that...
Abstract Myosin disordered‐ and super‐relaxed states (DRX SRX, respectively) in skeletal muscle fibers are hypothesized to play key roles thermogenesis basal metabolic energy expenditure, raising potential for novel therapeutic targets obesity other diseases. Limited studies have investigated relationships between body composition or biological sex myosin relaxed states. Using fluorescence‐based single‐nucleotide turnover, we report quantitative of diet‐induced adiposity with biochemical...
We have investigated individual InAs quantum dots embedded in GaAs using photoluminescence spectroscopy as a function of temperature and excitation power density. also present $\mathbf{k}\ensuremath{\cdot}\mathbf{p}$ calculations including both direct exchange interactions for systems with up to three excitons the dot. From these we are able assign some many peaks observed various few-particle states. A rate-equation model has been developed which allows simulations peak intensities density...
The Chlamydomonas anterograde intraflagellar transport motor, kinesin-2, is isolated as a heterotrimeric complex containing two motor subunits and nonmotor subunit known kinesin-associated polypeptide or KAP. One of the encoded by FLA10 gene. sequence second was obtained mass spectrometry sequencing. It shows 46.9% identity with Fla10 gene maps to linkage group XII/XIII near RPL9. temperature-sensitive flagellar assembly mutants fla1 fla8 are linked this kinesin-2 subunit. In each strain,...
Recent molecular dynamics (MD) simulations of proteins have suggested that common force fields overestimate the strength amino acid interactions in aqueous solution. In an attempt to determine causes these effects, we measured osmotic coefficients a number acids using AMBER ff99SB-ILDN field with two popular water models, and compared results available experimental data. With TIP4P-Ew water, between aliphatic residues agree well experiment, but polar serine threonine are found be excessively...
We have studied the formation of strained InAs and InP island structures on GaP surfaces grown by chemical beam epitaxy. grows pseudomorphically for 3 ML before crystallization is observed reflection high-energy electron diffraction, following a typical Stranski–Krastanov growth mode. For GaP, three-dimensional diffraction peaks are after 0.9 been deposited, indicating Volmer–Weber Atomic force microscopy studies these presented optical properties discussed.
A wind tunnel test program was conducted to investigate various techniques for reducing grid fin drag levels. Six different configurations were tested determine the effects of outer frame crosssection shape and web thickness. The fins mounted on four individual balances near aft end a body-ofrevolution. Test parameters included: angle attack (-8 20 degrees), deflection (0, 10 Mach number (0.5 2.5). results obtained indicate that cross-section thickness have significant effect characteristics...