A5042444062- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- Long-Term Effects of COVID-19
- Inhalation and Respiratory Drug Delivery
- Sarcoidosis and Beryllium Toxicity Research
- Protein Tyrosine Phosphatases
- Mast cells and histamine
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Cystic Fibrosis Research Advances
- Systemic Sclerosis and Related Diseases
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- Phosphodiesterase function and regulation
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Inflammatory Myopathies and Dermatomyositis
- Occupational exposure and asthma
- Healthcare professionals’ stress and burnout
- Eosinophilic Disorders and Syndromes
- Dysphagia Assessment and Management
- Pharmacological Receptor Mechanisms and Effects
- COVID-19 diagnosis using AI
- Drug-Induced Adverse Reactions
National Jewish Health
2011-2025
University of Colorado Denver
2011-2025
University of Colorado Anschutz Medical Campus
2021
SUNY Downstate Health Sciences University
2019
NewYork–Presbyterian Brooklyn Methodist Hospital
2019
Cornell University
2019
Stony Brook University Hospital
2019
National Institute for Occupational Safety and Health
2019
Pulmonary and Critical Care Associates
2011-2018
Ottawa Hospital Research Institute
2012
Fibrotic interstitial pneumonias are more prevalent in males of advancing age, although little is known about the underlying mechanisms. To evaluate contributions age and sex to development pulmonary fibrosis, we intratracheally instilled young (8-12 wk) aged (52-54 male female mice with bleomycin assessed severity fibrotic lung disease by measurements collagen levels, static compliance, leukocyte infiltration, stereological quantification areas histological sections. We also quantified...
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Idiopathic pulmonary fibrosis (IPF) is associated with the accumulation of collagen-secreting fibroblasts and myofibroblasts in lung parenchyma. Many mechanisms contribute to their accumulation, including resistance apoptosis. In previous work, we showed that exposure proinflammatory cytokines TNF-α IFN-γ reverses this study, investigate underlying mechanisms. Based on an interrogation transcriptomes unstimulated TNF-α- IFN-γ-stimulated primary fibroblast cell line MRC5, show among...
Rheumatoid arthritis–associated interstitial lung disease (RA-ILD) is associated with increased mortality in up to 10% of patients rheumatoid arthritis. Lung exposure cigarette smoke has been implicated development. Little known about the mechanisms underlying development RA-ILD, part due lack an appropriate mouse model. The objectives this study were (i) test suitability SKG mice as a model cellular and fibrotic pneumonia setting autoimmune arthritis, (ii) determine role injury arthritis...
Rheumatoid arthritis (RA) is a sexually dimorphic inflammatory autoimmune disease with both articular and extraarticular manifestations, including RA-associated interstitial lung disease. Low levels of testosterone have been linked to severity in men RA, supplemental has shown improve RA symptoms postmenopausal women low testosterone. The mechanisms by which sex steroids affect the immune system autoimmunity are poorly understood. purpose this study was examine protective effects...
Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease characterized by (myo)fibroblast accumulation and collagen deposition. Resistance to Fas-induced apoptosis thought facilitate persistence in tissues poorly understood mechanisms.
Background A genomic classifier for usual interstitial pneumonia (gUIP) has been shown to predict histological UIP with high specificity, increasing diagnostic confidence idiopathic pulmonary fibrosis (IPF). Whether those positive gUIP classification exhibit a progressive, IPF-like phenotype remains unknown. Methods pooled, retrospective analysis of patients who underwent clinically indicated bronchoscopy testing at seven academic medical centres across the USA was performed. We assessed...
Interstitial lung disease (ILD) associated with connective tissue diseases (CTDs) is highly heterogeneous in its clinical presentation and course. The diagnosis management of CTD-ILD require a multidisciplinary approach involving, at minimum, rheumatologist, pulmonologist, radiologist. Close monitoring patients important to enable early detection progression inform decisions regarding the initiation or escalation pharmacotherapy. In absence guidelines how CTD-ILDs should be treated,...
Philip, Cecil MD; Kabani, Naureen; Keith, Rebecca Mehta, Parag Seidman, Roberta Ozeri, David MD Author Information
Non-cystic fibrosis bronchiectasis is a chronic inflammatory airway disease that results in permanent lung damage and can correlate with considerable clinical economic burden. There are gaps knowledge surrounding bronchiectasis, for which there no published US-based treatment guidelines or FDA-approved therapies. Given the current challenges care, authors of this article convened an AJMC® roundtable March 2024. This publication summarizes main findings situates them scholarly context....
Introduction: As an increasing number of patients present for ambulatory care following acute COVID-19, we set out to characterize and identify clinical predictors prolonged symptoms antibody seroconversion. We hypothesized that who with a high symptom burden are more likely have post-acute sequelae COVID-19 (PASC). Methods: All adults confirmed SARS-CoV-2 infection evaluated at single center between April September 2020 were studied retrospectively using logit model ANOVA; the importance...