A5053137144- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunotherapy and Immune Responses
- Airway Management and Intubation Techniques
- Vascular Anomalies and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- Occupational and environmental lung diseases
- Neuroendocrine Tumor Research Advances
- CAR-T cell therapy research
- Tumors and Oncological Cases
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- IgG4-Related and Inflammatory Diseases
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Ultrasound in Clinical Applications
- Intensive Care Unit Cognitive Disorders
- Peptidase Inhibition and Analysis
- Extracellular vesicles in disease
- Poisoning and overdose treatments
VA Greater Los Angeles Healthcare System
2012-2025
University of California, Los Angeles
2012-2024
Pulmonary and Critical Care Associates
2010-2024
University of California System
2020-2024
Inje University Haeundae Paik Hospital
2023
UCLA Health
2019-2022
APLA Health
2022
University of Michigan
2012-2020
Massachusetts General Hospital
2020
University Hospitals of Cleveland
2020
Tissue acquisition in lung cancer is vital for multiple reasons. Primary reasons reported molecular testing failure biopsy specimens include insufficient amount of tumor cells provided and inadequate tissue quality. Robotic bronchoscopy a new tool enabling peripheral pulmonary lesion sampling; however, diagnostic yield remains imperfect possibly due to the location nodules adjacent or outside airway. The 1.1-mm cryoprobe novel accesses 360-degree manner, thus potentially sampling...
<b><i>Background:</i></b> Bronchoscopy for the diagnosis of peripheral pulmonary lesions continues to present clinical challenges, despite increasing experience using newer guided techniques. Robotic bronchoscopic platforms have been developed potentially improve diagnostic yields. Previous studies in cadaver models demonstrated increased reach into lung periphery robotic systems compared similarly sized conventional bronchoscopes, although impact additional is...
Background A genomic classifier for usual interstitial pneumonia (gUIP) has been shown to predict histological UIP with high specificity, increasing diagnostic confidence idiopathic pulmonary fibrosis (IPF). Whether those positive gUIP classification exhibit a progressive, IPF-like phenotype remains unknown. Methods pooled, retrospective analysis of patients who underwent clinically indicated bronchoscopy testing at seven academic medical centres across the USA was performed. We assessed...
An emerging body of research by biologists and clinicians has demonstrated the clinical application small extracellular vesicles (sEVs, also commonly referred to as exosomes) biomarkers for cancer detections. sEVs isolated from various fluids such blood, saliva, urine, cerebrospinal fluid have been used biomarker discoveries with highly encouraging outcomes. Among discovered are those responsible multiple types immune responses. These recapitulated tumor microenvironments. Yet, despite...
Patients with multiple myeloma are immunosuppressed due to both the disease itself and immunosuppressive therapies. Thus, when presenting respiratory failure pulmonary opacities, pneumonia must be considered. However, while rare, immunomodulating medications used in treatment of can also cause potentially life-threatening failure, a distinction which has important implications.
Interstitial lung disease (ILD) represents a heterogenous group of diseases that have substantial morbidity and mortality. The Envisia Genomic Classifier (EGC) is test analyses RNA derived from transbronchial biopsy (TBBx) samples to make positive or negative genomic usual interstitial pneumonitis (UIP) designation. Our study assesses the ability for EGC predict progression disease, with longer duration follow-up than previous studies. Patients referred cryobiopsy outpatient workup ILD...
Lipoid pneumonia is an unusual form of pneumonitis. It categorized as either exogenous or endogenous, depending on the lipid source. Diagnosis requires a high index suspicion, with clues provided by history and characteristic radiographic findings. Evaluation samples obtained via
The balloon-expanding stents are widely available but rarely described for use within the tracheobronchial tree. This report describes our experience with these in airway stenosis particularly as a lobar salvage therapy.This was retrospective review of all records which were used at tertiary medical center. Ages, sex, location stenosis, etiology stent size, duration placement and associated interventions recorded. Patient's self-reported respiratory symptoms, dyspnea scale, radiographic...
Abstract Background Appropriate placement of left-sided double-lumen endotracheal tubes (LDLTs) is paramount for optimal visualization the operative field during thoracic surgeries that require single lung ventilation. LDLTs therefore confirmed with fiberoptic bronchoscopy (FOB) rather than clinical assessment alone. Recent studies have demonstrated ultrasound (US) superior to alone confirming LDLT, but no large trials compared US gold standard FOB. This noninferiority trial was devised...
Background: A significant number of patients with severe respiratory failure related to COVID-19 require prolonged mechanical ventilation. Minimal data exists regarding the timing, safety, and efficacy combined bedside percutaneous tracheostomy endoscopy gastrostomy tube placement in these patients. The safety for healthcare providers is also question. This study's objective was evaluate effectiveness Design Methods: a single arm, prospective cohort study acute requiring ventilation who...
Abstract Background: Effective immunotherapy options are lacking for patients with advanced non-small cell lung cancer (NSCLC) who progress on a programmed death-(ligand)1 [PD-(L)1] inhibitor and those epidermal growth factor receptor (EGFR) mutation or anaplastic lymphoma kinase (ALK) rearrangement positive after progression tyrosine (TKI) therapy. One potential approach to improve immune checkpoint efficacy in these patient populations is promote cytolytic T infiltration into tumors. This...
Abstract Background Incidental and screening-identified lung nodules are common, a bronchoscopic evaluation is frequently nondiagnostic. The Percepta Genomic Sequencing Classifier (GSC) genomic classifier developed in current former smokers which can be used for further risk stratification these patients. GSC has the capability of up-classifying patients with pre-bronchoscopy that high (> 60%) to “very risk” positive predictive value 91.5%. This prospective, randomized decision impact...
The increasing incidence of pleural effusions from a variety etiologies is associated with significant socioeconomic burden. Effective treatment for first requires comprehensive diagnostic work up encompassing analysis fluid chemistry, microbiology studies and invasive sampling, all which should be incorporated relevant clinical data to reach final diagnosis. This review article addresses current approaches effusions.
<b><i>Background:</i></b> The coronavirus disease 2019 (COVID-19) pandemic has drastically affected hospital and operating room (OR) workflow around the world as well trainee education. Many institutions have instituted mandatory preoperative SARS-CoV-2 PCR nasopharyngeal swab (NS) testing in patients who are low risk for COVID-19 prior to elective cases. This method, however, is challenging sensitivity, specificity, overall reliability of remains unclear....
Right heart thrombus in transit (RHTT) is a rare, severe form of venous thromboembolism that carries high mortality rate. The optimal treatment for RHTT has not been well established. Thrombolysis therapeutic modality but the risk bleeding complications including intracranial hemorrhage. Low-dose thrombolysis shown to be effective treating submassive pulmonary emboli without an increased complications, it studied patients with RHTT. Here, we discuss case 74-year-old male lung cancer and...