A5089384510- Transplantation: Methods and Outcomes
- Viral Infections and Immunology Research
- Congenital heart defects research
- Renal Transplantation Outcomes and Treatments
- Congenital Diaphragmatic Hernia Studies
- Tumors and Oncological Cases
- Congenital Heart Disease Studies
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac tumors and thrombi
- Cardiac Structural Anomalies and Repair
- Thyroid Cancer Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Metastasis and carcinoma case studies
- Cell Image Analysis Techniques
- Sinusitis and nasal conditions
- Cardiomyopathy and Myosin Studies
- AI in cancer detection
- Cardiac Valve Diseases and Treatments
- Electronic Health Records Systems
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biomedical Text Mining and Ontologies
- Mechanical Circulatory Support Devices
- Colorectal and Anal Carcinomas
- Pharmacology and Obesity Treatment
Kaiser Permanente
2024
Los Angeles Medical Center
2024
University of California, Los Angeles
2019-2023
UCLA Health
2020
New York University
2015-2018
NYU Langone Health
2017
Tissue acquisition in lung cancer is vital for multiple reasons. Primary reasons reported molecular testing failure biopsy specimens include insufficient amount of tumor cells provided and inadequate tissue quality. Robotic bronchoscopy a new tool enabling peripheral pulmonary lesion sampling; however, diagnostic yield remains imperfect possibly due to the location nodules adjacent or outside airway. The 1.1-mm cryoprobe novel accesses 360-degree manner, thus potentially sampling...
Noninvasive encapsulated follicular variant of papillary thyroid carcinoma, a diagnosis implying malignancy as carcinoma (PTC), has recently been reclassified to noninvasive neoplasm with papillary-like nuclear features (NIFTP) on surgical pathology. Due the effects such recategorization rate and clinical management algorithms, it is imperative that we explore whether presurgical fine-needle aspiration can differentiate NIFTP from PTC adenoma (FA).Cytology slides subjects final pathology...
Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (NEFVPTC) was recently reclassified as noninvasive neoplasm with papillary-like nuclear features (NIFTP). Excluding "carcinoma" from the new terminology shifted NIFTP out malignant category and altered Bethesda System for Reporting Thyroid Cytopathology (BSRTC) rates malignancy (ROMs) on fine-needle aspiration (FNA). Because potential effects management guidelines, we examined our ROM data.In total, 750 FNAs surgical...
The lungs are a common site of tumor metastasis. While morphology and immunophenotype can help differentiate primary from metastatic tumors, distinguishing pulmonary invasive mucinous adenocarcinoma (PIMA) colorectal (CRC) may occasionally be challenging due to overlapping morphological immunohistochemical features. Lineage-specific markers such as CDX2, TTF-1, napsin A helpful with non-mucinous (PNMA), however they non-specific insensitive when applied PIMA. SATB2 is newer marker that...
As an essential component of the sarcomere, actin thin filament stems from Z-disk extend toward middle sarcomere and overlaps with myosin thick filaments. Elongation cardiac is for normal maturation heart function. This process regulated by actin-binding proteins Leiomodins (LMODs), among which
BACKGROUND:Cardiac allograft vasculopathy (CAV) is a post-orthotopic heart transplant (OHT) complication driven by intimal smooth muscle proliferation and immune hyperactivity to donor tissue. Accelerated CAV leads failure within 1 year after receiving normal angiogram result. Viruses can contribute development, but SARS-CoV-2 infection has not been reported date. CASE REPORT:A 48-year-old man, 5 years OHT for non-ischemic cardiomyopathy, was admitted the Cardiac Care Unit with 3 days of...
The detection of primary anorectal melanoma on anal cytology is a rare and challenging diagnosis. We report case where showed isolated malignant cells with oval nuclei, prominent nucleoli, elongated wispy cytoplasmic projections. There was no evidence squamous dysplasia or melanin pigment identified. To the best our knowledge, this first reported detected in cytology. Detection malignancies other than cell carcinoma can be seen should considered when there intraepithelial neoplasia. Diagn....
The presentation of a cardiac hamartoma, an exceedingly rare and histologically benign tumor, can be variable. We describe case refractory ventricular tachycardia in patient with mass failing multiple pharmacologic procedural interventions, ultimately treated by transplantation diagnosed mesenchymal hamartoma. (Level Difficulty: Intermediate.)
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary syndrome that characterized by the accumulation of excess surfactant in space, leading to impaired gas exchange. Sirolimus-induced PAP an extremely entity has only been described literature small number case reports. We present 39-year-old female with acute lymphocytic leukemia who underwent stem cell transplant, complicated graft-versus-host-disease (GVHD) involving skin for which she was treated steroids, photopheresis, sirolimus,...
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), set of national standards teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, Diagnostic Medicine Therapeutic Pathology. For additional information, full list objectives all competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
Abstract Cardiac allograft vasculopathy (CAV) is the leading cause of graft failure following heart transplantation. Donor specific antibodies (DSA) contribute to CAV by triggering vessel inflammation and endothelial cell injury. This results in thickening arterial intima occlusion. In this study, we aim define innate adaptive immune cells mediating neointima formation using CAV+DSA+ rejected cardiac explants (N=3) GeoMx digital spatial profiling (DSP). Arterial regions containing...