A5069352572- Inflammatory Bowel Disease
- Microscopic Colitis
- Esophageal and GI Pathology
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- Bariatric Surgery and Outcomes
- Gastric Cancer Management and Outcomes
- Systemic Lupus Erythematosus Research
- Liver Disease Diagnosis and Treatment
- Celiac Disease Research and Management
- Hepatitis C virus research
- Peptidase Inhibition and Analysis
- Gastrointestinal disorders and treatments
- Clostridium difficile and Clostridium perfringens research
- Appendicitis Diagnosis and Management
- Tracheal and airway disorders
- Multiple Myeloma Research and Treatments
- Psoriasis: Treatment and Pathogenesis
- Global Health Care Issues
- Pericarditis and Cardiac Tamponade
- Medical Device Sterilization and Disinfection
- Diversity and Career in Medicine
University of California, Los Angeles
2022-2024
UCLA Health
2023
National Institute on Drug Abuse
2021
Bellevue Hospital Center
2021
New York University
2016-2021
NYU Langone Health
2020
Indiana University School of Medicine
2016
Objectives: The purpose of this study was to assess the feasibility and clinical impact telemedicine-based opioid treatment with buprenorphine-naloxone following Coronavirus disease 2019 pandemic. Methods: Participants included in retrospective analysis consisted adult New York City residents use disorder eligible for enrollment NYC Health+Hospitals Virtual Buprenorphine Clinic between March May 2020 (n = 78). Follow-up data were comprised rates retention at 2 months, referrals community...
To evaluate pulmonary embolism (PE) prevalence at CT angiography in patients testing positive for coronavirus disease 2019 (COVID-19) and factors associated with PE severity.
High-grade glioma (HGG), a deadly primary brain malignancy, manifests radioresistance mediated by cell-intrinsic and microenvironmental mechanisms. High levels of the cytokine transforming growth factor-β (TGF-β) in HGG promote enforcing an effective DNA damage response supporting stem cell self-renewal. Our analysis TCGA data immunohistochemical staining phosphorylated Smad2, which is main transducer canonical TGF-β signaling, indicated variable pathway activation across tumors. These...
Abstract Background The era of biologics is associated with declining rates surgery for Crohn’s disease (CD), but the impact on stricturing CD unknown. Our study aimed to assess nationwide trends in bowel resection obstruction since introduction infliximab 1998. Methods Using Nationwide Inpatient Sample, we performed a analysis, identifying patients hospitalized who underwent an indication between 1998 and 2020 (era biologics). Longitudinal all CD-related resections were evaluated....
Patients with multiple myeloma are immunosuppressed due to both the disease itself and immunosuppressive therapies. Thus, when presenting respiratory failure pulmonary opacities, pneumonia must be considered. However, while rare, immunomodulating medications used in treatment of can also cause potentially life-threatening failure, a distinction which has important implications.
<b><i>Introduction:</i></b> Polyethylene glycol 3,350 and electrolytes is a commonly prescribed bowel regimen for colonoscopy preparation with an overall excellent safety profile, though prior reports have demonstrated risk of volume overload. <b><i>Case Presentation:</i></b> A 55-year-old man significant cardiopulmonary co-morbidities was admitted acute hypoxic respiratory failure subsequent evaluation lung transplant. As part his...
The purpose of this study was to identify differences in imaging features between patients with confirmed right middle lobe (RML) torsion compared those suspected yet without torsion.This retrospective entailing a search radiology reports from April 1, 2014, 15, 2021, resulted 52 lobar and 4 torsion, supplemented by 2 additional cases before the period for total 6 cases. Four thoracic radiologists (1 an adjudicator) evaluated chest radiographs computed tomography (CT) examinations, Fisher...
Summary Background Clostridioides difficile infections (CDIs) are common among patients with inflammatory bowel disease (IBD) and can mimic exacerbate IBD flares, thus warranting appropriate testing during flares. Aims To examine recent trends in rates of CDI associated risk factors hospitalized patients, which may better inform targeted interventions to mitigate the infection. Methods This is a retrospective analysis using Nationwide Readmissions Database from 2010 2020 individuals Crohn's...
Antibiotics are a cornerstone in management of intra-abdominal abscesses Crohn's disease (CD). Yet, the optimal route antibiotic administration is poorly studied. We aimed to compare surgical and nonsurgical readmission outcomes for patients hospitalized from CD discharged on oral (PO) or intravenous (IV) antibiotics.
A 65-year-old man with chronic hepatitis C virus and hepatocellular carcinoma, after surgical resection chemotherapy, was started on a regimen of glecaprevir pibrentasavir for treatment his virus. Ten days later, he developed hepatotoxicity subsequent progression to hepatorenal syndrome (HRS). On discontinuation glecaprevir/pibrentasavir initiation HRS treatment, had improvement in renal hepatic function. Although there have been recent safety concerns surrounding injury secondary...
ABSTRACT Introduction Risk factors for gastric cancer in the United States are not well understood, especially populations with a low proportion of immigrants. We conducted matched case–control study Veteran Affairs Medical Center to identify risk cancer. Materials and Methods Gastric patients age- sex-matched controls were identified 1:4 ratio from January 1, 1997 October 31, 2018. Demographic, medical, endoscopic, histologic data extracted. performed conditional logistic regression...
1Department of Internal Medicine, David Geffen School University California, Los Angeles, CA, 90095, USA 2Departments Medicine and Pathology, Cedars Sinai Medical Center, 90048, 3Department VA Greater Angeles 90073, 4Division Gastroenterology, Hepatology Parenteral Nutrition, Dept Healthcare System, 5Department Human Nutrition at UCLA, aCorresponding Author: Joseph R. Pisegna, [email protected]
Introduction: To increase the transparency of clinical trial information, U.S. Congress passed Food and Drug Administration (FDA) Amendments Act 2007, which expanded prior legislation to mandate inclusion specific characteristics, such as funding source gender demographics, in a new basic results section on ClinicalTrials.gov. Few studies have examined extent key demographic characteristics sex race/ethnicity are reported for neurological trials Methods: As part National Initiative Minority...
Introduction: Polyethylene glycol 3350 and electrolytes (PEG) is a perceived safe commonly prescribed solution prior to colonoscopy, yet case reports suggest the potential for volume overload. We describe patient with cardiopulmonary comorbidities who developed pulmonary edema acute hypoxic respiratory failure (AHRF) due PEG administration. Case Description/Methods: A 55-year-old man interstitial lung disease (ILD), mild hypertension (pHTN), coronary artery (CAD) multiple stents was admitted...
INTRODUCTION: The regimen of glecaprevir and pibrentasvir is an effective treatment for hepatitis C (HCV), but FDA data suggests a risk hepatobiliary toxicity. Here, we discuss the first description hepatorenal syndrome secondary to toxicity from glecaprevir/pibrentasvir. CASE DESCRIPTION/METHODS: A 65-year-old man with chronic HCV (genotype 1a), alcohol use disorder, hepatocellular carcinoma (HCC), presented abdominal distention jaundice one month. He was diagnosed HCC in 2014 treated...
INTRODUCTION: Gastric cancer is one of the most common cancers worldwide, but evidence for screening and surveillance in US limited by sparse clinical research. While recent immigrants from endemic regions such as East Asia are known to be at high risk, it’s unclear what important risk factors a population with fewer immigrants. Therefore, we conducted matched case-control study VA medical center. METHODS: We identified individuals gastric using both tumor registry electronic record New York...