Obesity is associated with alterations in functionality of immune cells, like macrophages and natural killer (NK) leading to an increased risk for severe infections several cancer types. This study aimed examine cell populations functional NK parameters focusing on subset phenotypes normal-weight obese humans. Therefore, peripheral blood mononuclear cells (PBMCs) were isolated from individuals analyzed by flow cytometry. Results show no significant changes the frequency monocytes, B...

Obesity is associated with an increased colon cancer incidence, but underlying mechanisms remained unclear. Previous studies showed altered Natural killer (NK) cell functions in obese individuals. Therefore, we studied the impact of impaired NK functionality on risk obesity. In vitro investigations demonstrated a decreased IFN- γ secretion and cytotoxicity human cells against tumor after preincubation adipokine leptin. addition, leptin incubation expression activating receptors. animal...

<i>Background:</i> Recently, it has been shown that dietary lupin protein lowers plasma triglyceride concentrations in rats. In this study, we investigated the hypothesis effect is due to a downregulation of sterol regulatory element-binding (SREBP)-1c, transcription factor regulates expression lipogenic enzymes livers <i>Methods:</i> Two groups 12 rats each were fed semisynthetic diets containing 200 g/kg either casein (control group) or from <i>Lupinus...

Summary It has been shown that some dietary plant proteins beneficially influence lipid metabolism in animals. The effect of pea protein this respect however not yet investigated. Therefore, we studied the purified on rats. Twenty‐four rats received diets with either 200 g/kg casein or for 16 days. Concentrations triacylglycerols liver, plasma and lipoproteins did differ between both groups However, fed diet had a lower concentration total cholesterol liver very low density (VLDL) fraction...

Obesity is associated with an increased risk for several cancer types and altered phenotype functionality of natural killer (NK) cells. This study aimed to investigate the association overweight obesity NK cell functions receptor expression profiles in humans. Therefore, peripheral blood mononuclear cells (PBMCs) were isolated from normal weight, obese healthy donors. In depth analysis immune populations 23 different surface markers, including receptors, NK-cell-related markers as well...

<b><i>Background:</i></b> Acute kidney injury in critically ill patients is associated with the activation of protein catabolism and a negative nitrogen balance. Renal replacement therapy (RRT) aggravates this problem by eliminating substantial amount amino acids. However, there scarce data on removal characteristics modern dialysis membranes extended dialysis. <b><i>Methods:</i></b> This prospective study 10 sessions using...

Abstract Obesity is a widely spread disease and crucial risk factor for malign disorders, including breast cancer of women in the postmenopause. Studies demonstrated that case obesity natural killer (NK) cell functions like combating tumor cells are affected. This study aims to analyze NK receptor expression obese mice model postmenopausal cancer. Therefore, female BALB/c were fed either high fat or standard diet. Thereafter, ovaries ectomized syngeneic orthotopical injection 4T1-luc2 mouse...

In mammals, (n-3) PUFA and conjugated linoleic acids (CLA) act as activators of PPAR alpha alter nuclear concentrations sterol regulatory element-binding proteins (SREBP) in the liver, thereby influence hepatic lipid catabolism synthesis. this study, we investigated hypothesis that CLA exert similar effects liver laying hens. Thirty hens (64 weeks old) were fed diets containing 30 g/kg sunflower oil (control), fish (salmon oil) or TAG form (containing predominantly cis-9, trans-11 trans-10,...

Summary This study was performed to assess the effects of potato protein and fish on concentrations lipids in plasma lipoproteins expression genes involved lipid metabolism pigs used as an animal model. Therefore, 27 young male with average body weight 22 kg were fed diets supplemented extracted from potatoes (containing 849 g protein/kg dry matter), Alaska Pollack fillet a source 926 crude matter) or casein which control, for 3 weeks. Diets formulated supply identical amounts each by three...

Obesity was identified as a major risk factor for malignant diseases, but underlying mechanisms remain unclear. Natural killer (NK) cells, pivotal aspect of innate immunity, are capable identifying and killing virally infected tumor cells. Previous studies have shown altered NK cell functions in obesity, the current study aimed to investigate relationship between increased cancer obesity.To induce obesity male F344-rats received high-fat diet (34% fat) or control (4% fat). Thereafter,...

It has been hypothesized that the arginine:lysine ratio of dietary proteins influences cholesterol concentrations in plasma and liver men animals. This study was performed to test this hypothesis rats by using diets with various arginine lysine, differing their ratios.Two experiments growing were performed, some which received containing 4.5, 9 or 18 g arginine/kg lysine/kg, respectively, for a period 21 days. In first experiment, cholesterol-free diet used; second supplemented sodium...

Overweight and obesity are major public health challenges worldwide. Obesity is associated with a higher risk for the development of several cancer types, but specific mechanisms underlying link still unclear. Natural killer (NK) cells circulating lymphoid promoting elimination virus-infected tumor cells. Previous investigations demonstrated conflicting results concerning influence on functional NK cell parameters in small animal models. The aim present study was to clarify potential...

Obesity is a major public health problem with an increasing prevalence reaching pandemic levels. The incidence and mortality for colorectal cancer augmented in overweight obese individuals. Previous studies demonstrated impaired number, phenotype functionality of natural killer (NK) cells under conditions. So far, the influence obesity on NK tissue remained unclear. Therefore, aim study was to investigate occurrence localization tumors normal weight diet-induced rats.Wistar rats were fed...

Background: The association of obesity and an increased risk for severe infections various cancer types is well-described. Natural killer (NK) cells are circulating lymphoid promoters the immune response toward viruses malignant cells. As demonstrated in previous studies phenotype functionality NK impaired obesity. So far, majority animal were exclusively performed using ad libitum feeding regimes it remained unclear whether cell alterations mediated by obesity-associated immunological...