A5023651495- Cardiovascular and exercise physiology
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Angiogenesis and VEGF in Cancer
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiac Health and Mental Health
- Physical Activity and Health
- Acute Myocardial Infarction Research
- Growth Hormone and Insulin-like Growth Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Non-Invasive Vital Sign Monitoring
- Congenital heart defects research
- Sports Performance and Training
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Cardiac Ischemia and Reperfusion
- Thermoregulation and physiological responses
- Peripheral Artery Disease Management
- Cardiac Fibrosis and Remodeling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mechanical Circulatory Support Devices
- Adipose Tissue and Metabolism
Tel Aviv University
2014-2025
Sheba Medical Center
2003-2024
Levin Group (United States)
2023
Moreno Valley College
2023
ORT Israel
2019
Israel Defense Forces Medical Corps
2017
Israel Medical Association
2011
MedStar Washington Hospital Center
2008-2010
Tel Aviv Sourasky Medical Center
2009
Rabin Medical Center
2008
BACKGROUND Vascular endothelial growth factor (VEGF) is an cell-specific mitogen that angiogenic in vitro and vivo. It has been hypothesized VEGF plays a role myocardial collateral formation; however, the effects of on flow to ischemic myocardium are unknown. METHODS AND RESULTS We studied effect blood dogs subjected gradual occlusion left circumflex coronary artery (LCx). Beginning 10 days after placement LCx-constricting device, 45 micrograms (n = 9) or saline 12) was administered daily...
We have shown that the angiogenic peptides basic fibroblast growth factor (bFGF) and vascular endothelial (VEGF) enhance canine coronary collateral development when administered for > or = 4 weeks. bFGF, a pluripotent mitogen of mesodermally derived cells, could theoretically exacerbate neointimal smooth muscle cell hyperplasia, fundamental component atherosclerosis. VEGF, an cell-specific permeability factor, deleterious effects related to hyperpermeability. The present investigation had...
Basic fibroblast growth factor (FGF) is a multifunctional peptide that may play an integral role in angiogenesis associated with coronary collateral formation and myocardial infarct healing. We sought to determine the effects of exogenously administered basic FGF on blood flow ischemic myocardium. Ameroid constrictors were used cause gradual occlusion left circumflex artery dogs. (110 micrograms, n = 9) or saline (n 12) was given as daily bolus injection directly into collateral-dependent...
Recently we reported that intracoronary administration of basic fibroblast growth factor (bFGF), a potent angiogenic peptide, increases collateral blood flow in dogs subjected to progressive left circumflex coronary artery (LCx) occlusion. The aim the present study was examine effect systemically administered bFGF on and assess its pharmacokinetics potential side effects.Forty-seven were ameroid-induced occlusion LCx, an intervention known induce development vessels. In phase I...
Healthy men (N = 1424, age 20-70 yr) underwent a progressive incremental treadmill exercise test to volitional maximum. Cardiopulmonary variables were measured breath-by-breath. The aerobic power (VO2max) declined at an average yearly rate of 0.33 ml.kg.-1min-1, HRmax 0.685 beats.min-1.yr-1, and max O2 pulse annual 0.115 ml.beat-1.kg-1*100. Gas exchange threshold (GET) expressed as percentage VO2max was 58% 69% in the youngest (20-30 oldest (61-70 decades, respectively. decline VE, Vt, f,...
To assess serum interleukin-1 beta (IL-1 beta) concentrations in patients with ischaemic heart disease, to characterise subgroups of raised IL-1 concentrations, and examine whether correlate non-specific indices inflammation.Survey study disease.Cardiac catheterisation laboratory a tertiary medical centre.Consecutive angina pectoris recovering from uncomplicated acute myocardial infarction undergoing elective coronary angiography.Mean(SD) were higher (P < 0.001) 50% artery stenosis (n = 11;...
Objective. At present, there is no consensus on the best strategy for interpreting cardiopulmonary exercise test’s (CPET) results. This study aimed at assessing potential of using computer-aided algorithms to evaluate CPET data identifying chronic heart failure (CHF) and obstructive pulmonary disease (COPD). Methods. Data from 234 files Pulmonary Institute, Sheba Medical Center, Givat-Washington College, both in Israel, were selected this study. The included patients with confirmed primary...
Asynchronous home-based cardiac rehabilitation (HBCR) is a viable alternative to center-based (CBCR). However, achieve significant functional improvement, high level of adherence and activity must be achieved. The effectiveness HBCR among patients who actively avoid CBCR has not been effectively investigated. This study aimed investigate the program unwilling participate in CBCR.